5‐Fluoro/(trifluoromethoxy)‐2‐indolinone derivatives with anti‐interleukin‐1 activity

The pro‐inflammatory cytokine interleukin‐1 (IL‐1) drives the pathogenesis of several inflammatory diseases. Recent studies have revealed that 2‐indolinones can modulate cytokine responses. Therefore, we screened several 2‐indolinone derivatives in preliminary studies to develop agents with anti‐IL‐...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2023-12, Vol.356 (12), p.e2300217-n/a
Hauptverfasser:	Soylu‐Eter, Özge, Sevinçli, Zekiye Şeyma, Ersoy, Betül, Hasanusta, Bahar, Gatfar, Uğur, Lack, Nathan A., Erman, Burak, Gül, Ahmet, Orer, Hakan S., Karalı, Nilgün
Format:	Artikel
Sprache:	eng
Schlagworte:	biological activity Cytokines molecular modeling structure–activity relationships synthesis design
Online-Zugang:	Volltext
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