Mediating effect of cumulative lipid profile burden on the effect of diet and obesity on hypertension incidence: a cohort study of people aged 35-65 in rural China
Background and objectives Cumulative lipid profile burden is designed to dynamically measure lipid accumulation, and its effect on hypertension has been poorly studied. Our main purpose was to investigate the effect of cumulative lipid profile burden on the incidence of essential hypertension (EH) a...
Gespeichert in:
| Veröffentlicht in: | European journal of clinical nutrition 2024-01, Vol.78 (1), p.54-63 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 63 |
|---|---|
| container_issue | 1 |
| container_start_page | 54 |
| container_title | European journal of clinical nutrition |
| container_volume | 78 |
| creator | Zhang, Ting Wang, Qi Cui, Xiao-mei Zhang, Yu-Ying Guo, Fang-xi Wu, Qing-feng Dong, Ming-Hua Luo, Xiao-Ting |
| description | Background and objectives
Cumulative lipid profile burden is designed to dynamically measure lipid accumulation, and its effect on hypertension has been poorly studied. Our main purpose was to investigate the effect of cumulative lipid profile burden on the incidence of essential hypertension (EH) and to investigate whether cumulative lipid burden mediates the pathogenesis of the effects of diet and obesity on EH.
Subjects and methods
A total of 1295 participants were included in the study, which started in 2017. The average follow-up time was 2.98 years. A total of 240 EH patients occurred during the follow-up period.
Results
The
HR
(95%
CI
) of the highest quartile in cumulative Total cholesterol (TC), triglyceride (TG) and high density lipoprotein (HDL) burden were 1.747 (1.145 - 2.664), 1.502 (1.038 - 2.173), 0.615 (0.413 - 0.917) for incidence of EH respectively, compared to the respective reference groups. Participants with EH consumed more red meat and refined grains, and red meat was positively associated with cumulative TC burden. BMI and Waist-To-Height Ratio (WHtR) increased the incidence of EH, and obesity was positively correlated with cumulative TG burden. Mediating analysis showed that cumulative TG had a partial mediating effect in the causal relationship between obesity and EH, and Mendelian randomization (MR) also proved this result. Diet was not found to influence EHn through cumulative lipid profile burden.
Conclusions
The cumulative TG burden partially mediates the effect of obesity on EH. |
| doi_str_mv | 10.1038/s41430-023-01348-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2875851840</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2875851840</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-965344507972b80f4e08ff258564eedecd05f0c5c5eec15f3be9c92fafbdc3443</originalsourceid><addsrcrecordid>eNp9kc2OFCEUhStG47SjL-DCkLhxU3opoIpyZzr-JWPc6JpQcOlmUg0lUJPp5_FFpe3xJy5c3XDvdw5wT9M8pfCSApOvMqecQQsda4EyLtvbe82G8qFvRc_hfrOBUfCWAQwXzaOcrwHqcOgeNhdskLSXvN803z-h9br4sCPoHJpCoiNmPaxzbd4gmf3iLVlSdH5GMq3JYiAxkLLHvwTWYyE6WBInzL4cT8T-uGAqGLKvBx-Mr0qDr4kmJu5jKiSX1R5P6gXjUs31Di1hou1FxUlak57Jdu-Dftw8cHrO-OSuXjZf3739sv3QXn1-_3H75qo1rOtLO_aCcS5gGIdukuA4gnSuE7JuA9GisSAcGGEEoqHCsQlHM3ZOu8maqmSXzYuzb_3utxVzUQefDc6zDhjXrDo5VDMqOVT0-T_odVxTqK9T3UjrbgGErFR3pkyKOSd0akn-oNNRUVCnCNU5QlUjVD8jVLdV9OzOep0OaH9LfmVWAXYGch2FHaY_d__H9geL6qjd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2911680058</pqid></control><display><type>article</type><title>Mediating effect of cumulative lipid profile burden on the effect of diet and obesity on hypertension incidence: a cohort study of people aged 35-65 in rural China</title><source>Alma/SFX Local Collection</source><creator>Zhang, Ting ; Wang, Qi ; Cui, Xiao-mei ; Zhang, Yu-Ying ; Guo, Fang-xi ; Wu, Qing-feng ; Dong, Ming-Hua ; Luo, Xiao-Ting</creator><creatorcontrib>Zhang, Ting ; Wang, Qi ; Cui, Xiao-mei ; Zhang, Yu-Ying ; Guo, Fang-xi ; Wu, Qing-feng ; Dong, Ming-Hua ; Luo, Xiao-Ting</creatorcontrib><description>Background and objectives
Cumulative lipid profile burden is designed to dynamically measure lipid accumulation, and its effect on hypertension has been poorly studied. Our main purpose was to investigate the effect of cumulative lipid profile burden on the incidence of essential hypertension (EH) and to investigate whether cumulative lipid burden mediates the pathogenesis of the effects of diet and obesity on EH.
Subjects and methods
A total of 1295 participants were included in the study, which started in 2017. The average follow-up time was 2.98 years. A total of 240 EH patients occurred during the follow-up period.
Results
The
HR
(95%
CI
) of the highest quartile in cumulative Total cholesterol (TC), triglyceride (TG) and high density lipoprotein (HDL) burden were 1.747 (1.145 - 2.664), 1.502 (1.038 - 2.173), 0.615 (0.413 - 0.917) for incidence of EH respectively, compared to the respective reference groups. Participants with EH consumed more red meat and refined grains, and red meat was positively associated with cumulative TC burden. BMI and Waist-To-Height Ratio (WHtR) increased the incidence of EH, and obesity was positively correlated with cumulative TG burden. Mediating analysis showed that cumulative TG had a partial mediating effect in the causal relationship between obesity and EH, and Mendelian randomization (MR) also proved this result. Diet was not found to influence EHn through cumulative lipid profile burden.
Conclusions
The cumulative TG burden partially mediates the effect of obesity on EH.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/s41430-023-01348-x</identifier><identifier>PMID: 37816846</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/699/75/243 ; Cholesterol ; Clinical Nutrition ; Diet ; Epidemiology ; High density lipoprotein ; Hypertension ; Internal Medicine ; Lipids ; Meat ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Obesity ; Pathogenesis ; Public Health ; Triglycerides</subject><ispartof>European journal of clinical nutrition, 2024-01, Vol.78 (1), p.54-63</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature Limited.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-965344507972b80f4e08ff258564eedecd05f0c5c5eec15f3be9c92fafbdc3443</cites><orcidid>0009-0003-1469-9350</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37816846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Ting</creatorcontrib><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Cui, Xiao-mei</creatorcontrib><creatorcontrib>Zhang, Yu-Ying</creatorcontrib><creatorcontrib>Guo, Fang-xi</creatorcontrib><creatorcontrib>Wu, Qing-feng</creatorcontrib><creatorcontrib>Dong, Ming-Hua</creatorcontrib><creatorcontrib>Luo, Xiao-Ting</creatorcontrib><title>Mediating effect of cumulative lipid profile burden on the effect of diet and obesity on hypertension incidence: a cohort study of people aged 35-65 in rural China</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background and objectives
Cumulative lipid profile burden is designed to dynamically measure lipid accumulation, and its effect on hypertension has been poorly studied. Our main purpose was to investigate the effect of cumulative lipid profile burden on the incidence of essential hypertension (EH) and to investigate whether cumulative lipid burden mediates the pathogenesis of the effects of diet and obesity on EH.
Subjects and methods
A total of 1295 participants were included in the study, which started in 2017. The average follow-up time was 2.98 years. A total of 240 EH patients occurred during the follow-up period.
Results
The
HR
(95%
CI
) of the highest quartile in cumulative Total cholesterol (TC), triglyceride (TG) and high density lipoprotein (HDL) burden were 1.747 (1.145 - 2.664), 1.502 (1.038 - 2.173), 0.615 (0.413 - 0.917) for incidence of EH respectively, compared to the respective reference groups. Participants with EH consumed more red meat and refined grains, and red meat was positively associated with cumulative TC burden. BMI and Waist-To-Height Ratio (WHtR) increased the incidence of EH, and obesity was positively correlated with cumulative TG burden. Mediating analysis showed that cumulative TG had a partial mediating effect in the causal relationship between obesity and EH, and Mendelian randomization (MR) also proved this result. Diet was not found to influence EHn through cumulative lipid profile burden.
Conclusions
The cumulative TG burden partially mediates the effect of obesity on EH.</description><subject>692/499</subject><subject>692/699/75/243</subject><subject>Cholesterol</subject><subject>Clinical Nutrition</subject><subject>Diet</subject><subject>Epidemiology</subject><subject>High density lipoprotein</subject><subject>Hypertension</subject><subject>Internal Medicine</subject><subject>Lipids</subject><subject>Meat</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Obesity</subject><subject>Pathogenesis</subject><subject>Public Health</subject><subject>Triglycerides</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kc2OFCEUhStG47SjL-DCkLhxU3opoIpyZzr-JWPc6JpQcOlmUg0lUJPp5_FFpe3xJy5c3XDvdw5wT9M8pfCSApOvMqecQQsda4EyLtvbe82G8qFvRc_hfrOBUfCWAQwXzaOcrwHqcOgeNhdskLSXvN803z-h9br4sCPoHJpCoiNmPaxzbd4gmf3iLVlSdH5GMq3JYiAxkLLHvwTWYyE6WBInzL4cT8T-uGAqGLKvBx-Mr0qDr4kmJu5jKiSX1R5P6gXjUs31Di1hou1FxUlak57Jdu-Dftw8cHrO-OSuXjZf3739sv3QXn1-_3H75qo1rOtLO_aCcS5gGIdukuA4gnSuE7JuA9GisSAcGGEEoqHCsQlHM3ZOu8maqmSXzYuzb_3utxVzUQefDc6zDhjXrDo5VDMqOVT0-T_odVxTqK9T3UjrbgGErFR3pkyKOSd0akn-oNNRUVCnCNU5QlUjVD8jVLdV9OzOep0OaH9LfmVWAXYGch2FHaY_d__H9geL6qjd</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Zhang, Ting</creator><creator>Wang, Qi</creator><creator>Cui, Xiao-mei</creator><creator>Zhang, Yu-Ying</creator><creator>Guo, Fang-xi</creator><creator>Wu, Qing-feng</creator><creator>Dong, Ming-Hua</creator><creator>Luo, Xiao-Ting</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0003-1469-9350</orcidid></search><sort><creationdate>20240101</creationdate><title>Mediating effect of cumulative lipid profile burden on the effect of diet and obesity on hypertension incidence: a cohort study of people aged 35-65 in rural China</title><author>Zhang, Ting ; Wang, Qi ; Cui, Xiao-mei ; Zhang, Yu-Ying ; Guo, Fang-xi ; Wu, Qing-feng ; Dong, Ming-Hua ; Luo, Xiao-Ting</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-965344507972b80f4e08ff258564eedecd05f0c5c5eec15f3be9c92fafbdc3443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>692/499</topic><topic>692/699/75/243</topic><topic>Cholesterol</topic><topic>Clinical Nutrition</topic><topic>Diet</topic><topic>Epidemiology</topic><topic>High density lipoprotein</topic><topic>Hypertension</topic><topic>Internal Medicine</topic><topic>Lipids</topic><topic>Meat</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Obesity</topic><topic>Pathogenesis</topic><topic>Public Health</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Ting</creatorcontrib><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Cui, Xiao-mei</creatorcontrib><creatorcontrib>Zhang, Yu-Ying</creatorcontrib><creatorcontrib>Guo, Fang-xi</creatorcontrib><creatorcontrib>Wu, Qing-feng</creatorcontrib><creatorcontrib>Dong, Ming-Hua</creatorcontrib><creatorcontrib>Luo, Xiao-Ting</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Ting</au><au>Wang, Qi</au><au>Cui, Xiao-mei</au><au>Zhang, Yu-Ying</au><au>Guo, Fang-xi</au><au>Wu, Qing-feng</au><au>Dong, Ming-Hua</au><au>Luo, Xiao-Ting</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mediating effect of cumulative lipid profile burden on the effect of diet and obesity on hypertension incidence: a cohort study of people aged 35-65 in rural China</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>78</volume><issue>1</issue><spage>54</spage><epage>63</epage><pages>54-63</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Background and objectives
Cumulative lipid profile burden is designed to dynamically measure lipid accumulation, and its effect on hypertension has been poorly studied. Our main purpose was to investigate the effect of cumulative lipid profile burden on the incidence of essential hypertension (EH) and to investigate whether cumulative lipid burden mediates the pathogenesis of the effects of diet and obesity on EH.
Subjects and methods
A total of 1295 participants were included in the study, which started in 2017. The average follow-up time was 2.98 years. A total of 240 EH patients occurred during the follow-up period.
Results
The
HR
(95%
CI
) of the highest quartile in cumulative Total cholesterol (TC), triglyceride (TG) and high density lipoprotein (HDL) burden were 1.747 (1.145 - 2.664), 1.502 (1.038 - 2.173), 0.615 (0.413 - 0.917) for incidence of EH respectively, compared to the respective reference groups. Participants with EH consumed more red meat and refined grains, and red meat was positively associated with cumulative TC burden. BMI and Waist-To-Height Ratio (WHtR) increased the incidence of EH, and obesity was positively correlated with cumulative TG burden. Mediating analysis showed that cumulative TG had a partial mediating effect in the causal relationship between obesity and EH, and Mendelian randomization (MR) also proved this result. Diet was not found to influence EHn through cumulative lipid profile burden.
Conclusions
The cumulative TG burden partially mediates the effect of obesity on EH.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>37816846</pmid><doi>10.1038/s41430-023-01348-x</doi><tpages>10</tpages><orcidid>https://orcid.org/0009-0003-1469-9350</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-3007 |
| ispartof | European journal of clinical nutrition, 2024-01, Vol.78 (1), p.54-63 |
| issn | 0954-3007 1476-5640 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2875851840 |
| source | Alma/SFX Local Collection |
| subjects | 692/499 692/699/75/243 Cholesterol Clinical Nutrition Diet Epidemiology High density lipoprotein Hypertension Internal Medicine Lipids Meat Medicine Medicine & Public Health Metabolic Diseases Obesity Pathogenesis Public Health Triglycerides |
| title | Mediating effect of cumulative lipid profile burden on the effect of diet and obesity on hypertension incidence: a cohort study of people aged 35-65 in rural China |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T01%3A00%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mediating%20effect%20of%20cumulative%20lipid%20profile%20burden%20on%20the%20effect%20of%20diet%20and%20obesity%20on%20hypertension%20incidence:%20a%20cohort%20study%20of%20people%20aged%2035-65%20in%20rural%20China&rft.jtitle=European%20journal%20of%20clinical%20nutrition&rft.au=Zhang,%20Ting&rft.date=2024-01-01&rft.volume=78&rft.issue=1&rft.spage=54&rft.epage=63&rft.pages=54-63&rft.issn=0954-3007&rft.eissn=1476-5640&rft_id=info:doi/10.1038/s41430-023-01348-x&rft_dat=%3Cproquest_cross%3E2875851840%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2911680058&rft_id=info:pmid/37816846&rfr_iscdi=true |