Efficacy of uterine artery embolization (UAE) for uterine fibroids according to FIGO classification: a single-center experience

Objective This study aims to retrospectively evaluate the outcomes of uterine artery embolization (UAE) for uterine fibroids (UFs), specifically submucosal UFs, according to the International Federation of Gynecology and Obstetrics (FIGO) classification of UFs. Materials and methods Forty-two patien...

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Veröffentlicht in:Japanese journal of radiology 2024-02, Vol.42 (2), p.174-181
Hauptverfasser: Ito, Hiroe, Nakai, Motoki, Yunaiyama, Daisuke, Shirota, Natsuhiko, Kobayashi, Takehiro, Yasutomi, Mika, Kikuchi, Takayuki, Kinoshita, Yuta, Takara, Yuki, Tanaka, Taro, Saguchi, Toru, Saito, Kazuhiro
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container_title Japanese journal of radiology
container_volume 42
creator Ito, Hiroe
Nakai, Motoki
Yunaiyama, Daisuke
Shirota, Natsuhiko
Kobayashi, Takehiro
Yasutomi, Mika
Kikuchi, Takayuki
Kinoshita, Yuta
Takara, Yuki
Tanaka, Taro
Saguchi, Toru
Saito, Kazuhiro
description Objective This study aims to retrospectively evaluate the outcomes of uterine artery embolization (UAE) for uterine fibroids (UFs), specifically submucosal UFs, according to the International Federation of Gynecology and Obstetrics (FIGO) classification of UFs. Materials and methods Forty-two patients with symptomatic UFs underwent UAE with Embosphere ® between July 2016 and November 2021. MRI was performed before, at 3 and 6 months after the UAE. At each examination, the volume of UF was measured, and the percentage volume reduction rate (VRR) was calculated. The technical success rate (TSR), symptom improvement rate (SIR), regrowth rate (RR) after 6 months, and adverse events (AEs) were examined; VRR was compared between patients with submucosal UFs (FIGO types 0–2, group A), those with submucosal contacts (FIGO type 3, group B), and those without submucosal UFs (FIGO types 4–7, group C). Statistical analysis was performed on the difference in VRR between groups A, B, and C at 3 and 6 months after UAE. The relationship with hormone levels before UAE and VRR was evaluated. Results Thirty-seven of the 42 patients were evaluated. Overall, VRR was 37.0% at 3 months and 52.1% at 6 months; TSR, SIR, and RR were 100%, 95.2%, and 5.4%, respectively; VRR at 6 months was 80.7% for group A ( n  = 7), 57.8% for group B ( n  = 13), and 37.1% for group C ( n  = 17). Significant differences were found between A and C ( p  
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Materials and methods Forty-two patients with symptomatic UFs underwent UAE with Embosphere ® between July 2016 and November 2021. MRI was performed before, at 3 and 6 months after the UAE. At each examination, the volume of UF was measured, and the percentage volume reduction rate (VRR) was calculated. The technical success rate (TSR), symptom improvement rate (SIR), regrowth rate (RR) after 6 months, and adverse events (AEs) were examined; VRR was compared between patients with submucosal UFs (FIGO types 0–2, group A), those with submucosal contacts (FIGO type 3, group B), and those without submucosal UFs (FIGO types 4–7, group C). Statistical analysis was performed on the difference in VRR between groups A, B, and C at 3 and 6 months after UAE. The relationship with hormone levels before UAE and VRR was evaluated. Results Thirty-seven of the 42 patients were evaluated. Overall, VRR was 37.0% at 3 months and 52.1% at 6 months; TSR, SIR, and RR were 100%, 95.2%, and 5.4%, respectively; VRR at 6 months was 80.7% for group A ( n  = 7), 57.8% for group B ( n  = 13), and 37.1% for group C ( n  = 17). Significant differences were found between A and C ( p  &lt; 0.001) and B and C ( p  = 0.023). Hormone levels before UAE had no effect on VRR. There was no significant AEs other than grade 3 pulmonary embolism in one patient. Conclusion UAE was effective for submucosal FIGO types 0–3. UAE was especially useful as an option for FIGO type 3 with a low protrusion rate that is difficult to treat with transcervical resection.</description><identifier>ISSN: 1867-1071</identifier><identifier>EISSN: 1867-108X</identifier><identifier>DOI: 10.1007/s11604-023-01492-1</identifier><identifier>PMID: 37815695</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Classification ; Embolism ; Embolization ; Evaluation ; Female ; Fibroids ; Gynecology ; Hormones ; Humans ; Imaging ; Leiomyoma - diagnostic imaging ; Leiomyoma - therapy ; Medicine ; Medicine &amp; Public Health ; Nuclear Medicine ; Obstetrics ; Original Article ; Pregnancy ; Radiology ; Radiotherapy ; Regrowth ; Retrospective Studies ; Statistical analysis ; Treatment Outcome ; Uterine Artery Embolization ; Uterine Neoplasms - therapy ; Uterus</subject><ispartof>Japanese journal of radiology, 2024-02, Vol.42 (2), p.174-181</ispartof><rights>The Author(s) under exclusive licence to Japan Radiological Society 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s) under exclusive licence to Japan Radiological Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c392t-fdaa86258d03d94399fb380b1d17c7de66405e15fa0d70b25470fb6bd61d37bd3</cites><orcidid>0000-0001-7300-6030</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11604-023-01492-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11604-023-01492-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37815695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ito, Hiroe</creatorcontrib><creatorcontrib>Nakai, Motoki</creatorcontrib><creatorcontrib>Yunaiyama, Daisuke</creatorcontrib><creatorcontrib>Shirota, Natsuhiko</creatorcontrib><creatorcontrib>Kobayashi, Takehiro</creatorcontrib><creatorcontrib>Yasutomi, Mika</creatorcontrib><creatorcontrib>Kikuchi, Takayuki</creatorcontrib><creatorcontrib>Kinoshita, Yuta</creatorcontrib><creatorcontrib>Takara, Yuki</creatorcontrib><creatorcontrib>Tanaka, Taro</creatorcontrib><creatorcontrib>Saguchi, Toru</creatorcontrib><creatorcontrib>Saito, Kazuhiro</creatorcontrib><title>Efficacy of uterine artery embolization (UAE) for uterine fibroids according to FIGO classification: a single-center experience</title><title>Japanese journal of radiology</title><addtitle>Jpn J Radiol</addtitle><addtitle>Jpn J Radiol</addtitle><description>Objective This study aims to retrospectively evaluate the outcomes of uterine artery embolization (UAE) for uterine fibroids (UFs), specifically submucosal UFs, according to the International Federation of Gynecology and Obstetrics (FIGO) classification of UFs. Materials and methods Forty-two patients with symptomatic UFs underwent UAE with Embosphere ® between July 2016 and November 2021. MRI was performed before, at 3 and 6 months after the UAE. At each examination, the volume of UF was measured, and the percentage volume reduction rate (VRR) was calculated. The technical success rate (TSR), symptom improvement rate (SIR), regrowth rate (RR) after 6 months, and adverse events (AEs) were examined; VRR was compared between patients with submucosal UFs (FIGO types 0–2, group A), those with submucosal contacts (FIGO type 3, group B), and those without submucosal UFs (FIGO types 4–7, group C). Statistical analysis was performed on the difference in VRR between groups A, B, and C at 3 and 6 months after UAE. The relationship with hormone levels before UAE and VRR was evaluated. Results Thirty-seven of the 42 patients were evaluated. Overall, VRR was 37.0% at 3 months and 52.1% at 6 months; TSR, SIR, and RR were 100%, 95.2%, and 5.4%, respectively; VRR at 6 months was 80.7% for group A ( n  = 7), 57.8% for group B ( n  = 13), and 37.1% for group C ( n  = 17). Significant differences were found between A and C ( p  &lt; 0.001) and B and C ( p  = 0.023). Hormone levels before UAE had no effect on VRR. There was no significant AEs other than grade 3 pulmonary embolism in one patient. Conclusion UAE was effective for submucosal FIGO types 0–3. UAE was especially useful as an option for FIGO type 3 with a low protrusion rate that is difficult to treat with transcervical resection.</description><subject>Classification</subject><subject>Embolism</subject><subject>Embolization</subject><subject>Evaluation</subject><subject>Female</subject><subject>Fibroids</subject><subject>Gynecology</subject><subject>Hormones</subject><subject>Humans</subject><subject>Imaging</subject><subject>Leiomyoma - diagnostic imaging</subject><subject>Leiomyoma - therapy</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Nuclear Medicine</subject><subject>Obstetrics</subject><subject>Original Article</subject><subject>Pregnancy</subject><subject>Radiology</subject><subject>Radiotherapy</subject><subject>Regrowth</subject><subject>Retrospective Studies</subject><subject>Statistical analysis</subject><subject>Treatment Outcome</subject><subject>Uterine Artery Embolization</subject><subject>Uterine Neoplasms - therapy</subject><subject>Uterus</subject><issn>1867-1071</issn><issn>1867-108X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kTtrHDEURkVIiB_JH0gRBGnsYhLd0Ywe7oxZP8DgJoZ0Qk8jMztaSzPgTZO_bq3X3oALV7pwz3d04UPoG5CfQAj_VQAY6RrS0oZAJ9sGPqB9EIw3QMSfj7uZwx46KOWeENbRrvuM9igX0DPZ76N_ixCi1XaNU8Dz5HMcPda5DmvslyYN8a-eYhrx0e3p4hiHlHdUiCan6ArW1qbs4niHp4TPry5usB10KXEj3mRPsMalrgffWD_WNPaPq-rwo_Vf0Kegh-K_vryH6PZ88fvssrm-ubg6O71uLJXt1ASntWBtLxyhTnZUymCoIAYccMudZ6wjvYc-aOI4MW3fcRIMM46Bo9w4eoiOtt5VTg-zL5NaxmL9MOjRp7moVvCeCpCcVPTHG_Q-zXms16lWgqCVkX2l2i1lcyol-6BWOS51XisgalOP2tajaj3quR4FNfT9RT2bpXe7yGsfFaBboNTVeOfz_7_f0T4BYtubWw</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Ito, Hiroe</creator><creator>Nakai, Motoki</creator><creator>Yunaiyama, Daisuke</creator><creator>Shirota, Natsuhiko</creator><creator>Kobayashi, Takehiro</creator><creator>Yasutomi, Mika</creator><creator>Kikuchi, Takayuki</creator><creator>Kinoshita, Yuta</creator><creator>Takara, Yuki</creator><creator>Tanaka, Taro</creator><creator>Saguchi, Toru</creator><creator>Saito, Kazuhiro</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7300-6030</orcidid></search><sort><creationdate>20240201</creationdate><title>Efficacy of uterine artery embolization (UAE) for uterine fibroids according to FIGO classification: a single-center experience</title><author>Ito, Hiroe ; Nakai, Motoki ; Yunaiyama, Daisuke ; Shirota, Natsuhiko ; Kobayashi, Takehiro ; Yasutomi, Mika ; Kikuchi, Takayuki ; Kinoshita, Yuta ; Takara, Yuki ; Tanaka, Taro ; Saguchi, Toru ; Saito, Kazuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-fdaa86258d03d94399fb380b1d17c7de66405e15fa0d70b25470fb6bd61d37bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Classification</topic><topic>Embolism</topic><topic>Embolization</topic><topic>Evaluation</topic><topic>Female</topic><topic>Fibroids</topic><topic>Gynecology</topic><topic>Hormones</topic><topic>Humans</topic><topic>Imaging</topic><topic>Leiomyoma - diagnostic imaging</topic><topic>Leiomyoma - therapy</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Nuclear Medicine</topic><topic>Obstetrics</topic><topic>Original Article</topic><topic>Pregnancy</topic><topic>Radiology</topic><topic>Radiotherapy</topic><topic>Regrowth</topic><topic>Retrospective Studies</topic><topic>Statistical analysis</topic><topic>Treatment Outcome</topic><topic>Uterine Artery Embolization</topic><topic>Uterine Neoplasms - therapy</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ito, Hiroe</creatorcontrib><creatorcontrib>Nakai, Motoki</creatorcontrib><creatorcontrib>Yunaiyama, Daisuke</creatorcontrib><creatorcontrib>Shirota, Natsuhiko</creatorcontrib><creatorcontrib>Kobayashi, Takehiro</creatorcontrib><creatorcontrib>Yasutomi, Mika</creatorcontrib><creatorcontrib>Kikuchi, Takayuki</creatorcontrib><creatorcontrib>Kinoshita, Yuta</creatorcontrib><creatorcontrib>Takara, Yuki</creatorcontrib><creatorcontrib>Tanaka, Taro</creatorcontrib><creatorcontrib>Saguchi, Toru</creatorcontrib><creatorcontrib>Saito, Kazuhiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; 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Materials and methods Forty-two patients with symptomatic UFs underwent UAE with Embosphere ® between July 2016 and November 2021. MRI was performed before, at 3 and 6 months after the UAE. At each examination, the volume of UF was measured, and the percentage volume reduction rate (VRR) was calculated. The technical success rate (TSR), symptom improvement rate (SIR), regrowth rate (RR) after 6 months, and adverse events (AEs) were examined; VRR was compared between patients with submucosal UFs (FIGO types 0–2, group A), those with submucosal contacts (FIGO type 3, group B), and those without submucosal UFs (FIGO types 4–7, group C). Statistical analysis was performed on the difference in VRR between groups A, B, and C at 3 and 6 months after UAE. The relationship with hormone levels before UAE and VRR was evaluated. Results Thirty-seven of the 42 patients were evaluated. Overall, VRR was 37.0% at 3 months and 52.1% at 6 months; TSR, SIR, and RR were 100%, 95.2%, and 5.4%, respectively; VRR at 6 months was 80.7% for group A ( n  = 7), 57.8% for group B ( n  = 13), and 37.1% for group C ( n  = 17). Significant differences were found between A and C ( p  &lt; 0.001) and B and C ( p  = 0.023). Hormone levels before UAE had no effect on VRR. There was no significant AEs other than grade 3 pulmonary embolism in one patient. Conclusion UAE was effective for submucosal FIGO types 0–3. UAE was especially useful as an option for FIGO type 3 with a low protrusion rate that is difficult to treat with transcervical resection.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>37815695</pmid><doi>10.1007/s11604-023-01492-1</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7300-6030</orcidid></addata></record>
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subjects Classification
Embolism
Embolization
Evaluation
Female
Fibroids
Gynecology
Hormones
Humans
Imaging
Leiomyoma - diagnostic imaging
Leiomyoma - therapy
Medicine
Medicine & Public Health
Nuclear Medicine
Obstetrics
Original Article
Pregnancy
Radiology
Radiotherapy
Regrowth
Retrospective Studies
Statistical analysis
Treatment Outcome
Uterine Artery Embolization
Uterine Neoplasms - therapy
Uterus
title Efficacy of uterine artery embolization (UAE) for uterine fibroids according to FIGO classification: a single-center experience
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