Home-Use Hyaluronic Acid Jet Injectors: Unreliable and Unsafe
Needle-free hyaluronic acid (HA) jet injectors are gaining popularity for rejuvenation treatment. The devices are widely available online and are used for self-injection or in beauty salons by nonphysicians. However, little is known about their performance and safety. To explore the injection effici...
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| Veröffentlicht in: | Dermatologic surgery 2024-01, Vol.50 (1), p.62-68 |
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| creator | Juch, Rosalie N S Bik, Liora Boeijink, Neill de Vos, Judith Dobbe, Iwan J G G Bloemen, Paul R van Doorn, Martijn B A Velthuis, Peter Aalders, Maurice C G Wolkerstorfer, Albert |
| description | Needle-free hyaluronic acid (HA) jet injectors are gaining popularity for rejuvenation treatment. The devices are widely available online and are used for self-injection or in beauty salons by nonphysicians. However, little is known about their performance and safety.
To explore the injection efficiency and cutaneous biodistribution patterns administered with home-use compared with medical jet injectors and to assess safety aspects.
The authors injected HA into ex vivo human skin with 4 home-use and 2 medical injectors. The intracutaneous dose of HA was calculated, and the cutaneous biodistribution of HA was assessed using a 3-dimensional Fluorescent Imaging Cryomicrotome System (3D-FICS). Safety aspects were evaluated based on the presence of a manual, CE (conformité européenne) mark, and sterility.
The intracutaneous dose delivered by the home-use injectors was markedly lower compared with the medical injectors. 3D imaging for home-use injectors showed superficial epidermal distribution with low distribution volumes. For medical injectors, volumes were substantially larger and mainly middermal. All evaluated safety aspects were lacking.
Results of this study suggest that the specific combinations of home-use injectors and HA used in this study are unreliable and unsafe, which casts doubts on the performance of these treatments in general. |
| doi_str_mv | 10.1097/DSS.0000000000003971 |
| format | Article |
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To explore the injection efficiency and cutaneous biodistribution patterns administered with home-use compared with medical jet injectors and to assess safety aspects.
The authors injected HA into ex vivo human skin with 4 home-use and 2 medical injectors. The intracutaneous dose of HA was calculated, and the cutaneous biodistribution of HA was assessed using a 3-dimensional Fluorescent Imaging Cryomicrotome System (3D-FICS). Safety aspects were evaluated based on the presence of a manual, CE (conformité européenne) mark, and sterility.
The intracutaneous dose delivered by the home-use injectors was markedly lower compared with the medical injectors. 3D imaging for home-use injectors showed superficial epidermal distribution with low distribution volumes. For medical injectors, volumes were substantially larger and mainly middermal. All evaluated safety aspects were lacking.
Results of this study suggest that the specific combinations of home-use injectors and HA used in this study are unreliable and unsafe, which casts doubts on the performance of these treatments in general.</description><identifier>ISSN: 1076-0512</identifier><identifier>EISSN: 1524-4725</identifier><identifier>DOI: 10.1097/DSS.0000000000003971</identifier><identifier>PMID: 37815475</identifier><language>eng</language><publisher>United States</publisher><subject>Administration, Cutaneous ; Humans ; Hyaluronic Acid - adverse effects ; Hyaluronic Acid - metabolism ; Injections, Jet - methods ; Skin - metabolism ; Tissue Distribution</subject><ispartof>Dermatologic surgery, 2024-01, Vol.50 (1), p.62-68</ispartof><rights>Copyright © 2023 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-e6e85d8fcf5bb3060451749a9eb92913035b0f1701989d70487571996d0999523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37815475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Juch, Rosalie N S</creatorcontrib><creatorcontrib>Bik, Liora</creatorcontrib><creatorcontrib>Boeijink, Neill</creatorcontrib><creatorcontrib>de Vos, Judith</creatorcontrib><creatorcontrib>Dobbe, Iwan J G G</creatorcontrib><creatorcontrib>Bloemen, Paul R</creatorcontrib><creatorcontrib>van Doorn, Martijn B A</creatorcontrib><creatorcontrib>Velthuis, Peter</creatorcontrib><creatorcontrib>Aalders, Maurice C G</creatorcontrib><creatorcontrib>Wolkerstorfer, Albert</creatorcontrib><title>Home-Use Hyaluronic Acid Jet Injectors: Unreliable and Unsafe</title><title>Dermatologic surgery</title><addtitle>Dermatol Surg</addtitle><description>Needle-free hyaluronic acid (HA) jet injectors are gaining popularity for rejuvenation treatment. The devices are widely available online and are used for self-injection or in beauty salons by nonphysicians. However, little is known about their performance and safety.
To explore the injection efficiency and cutaneous biodistribution patterns administered with home-use compared with medical jet injectors and to assess safety aspects.
The authors injected HA into ex vivo human skin with 4 home-use and 2 medical injectors. The intracutaneous dose of HA was calculated, and the cutaneous biodistribution of HA was assessed using a 3-dimensional Fluorescent Imaging Cryomicrotome System (3D-FICS). Safety aspects were evaluated based on the presence of a manual, CE (conformité européenne) mark, and sterility.
The intracutaneous dose delivered by the home-use injectors was markedly lower compared with the medical injectors. 3D imaging for home-use injectors showed superficial epidermal distribution with low distribution volumes. For medical injectors, volumes were substantially larger and mainly middermal. All evaluated safety aspects were lacking.
Results of this study suggest that the specific combinations of home-use injectors and HA used in this study are unreliable and unsafe, which casts doubts on the performance of these treatments in general.</description><subject>Administration, Cutaneous</subject><subject>Humans</subject><subject>Hyaluronic Acid - adverse effects</subject><subject>Hyaluronic Acid - metabolism</subject><subject>Injections, Jet - methods</subject><subject>Skin - metabolism</subject><subject>Tissue Distribution</subject><issn>1076-0512</issn><issn>1524-4725</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1Lw0AQhhdRbK3-A5EcvaTOfmUzgodSP1opeKg9h00ygZR81N3k0H_fSKuIc5kZeJ8ZeBi75TDlgObheb2ewp-SaPgZG3MtVKiM0OfDDCYKQXMxYlfebwG4QAmXbCRNzLUyesyeFm1N4cZTsNjbqndtU2bBLCvz4J26YNlsKeta5x-DTeOoKm1aUWCbfFi9LeiaXRS28nRz6hO2eX35nC_C1cfbcj5bhZnQURdSRLHO4yIrdJpKiEBpbhRapBQFcglSp1BwAxxjzA2o2GjDEaMcEFELOWH3x7s713715LukLn1GVWUbanufiAGQMUethqg6RjPXeu-oSHaurK3bJxySb3HJIC75L27A7k4f-rSm_Bf6MSUP4etlfA</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Juch, Rosalie N S</creator><creator>Bik, Liora</creator><creator>Boeijink, Neill</creator><creator>de Vos, Judith</creator><creator>Dobbe, Iwan J G G</creator><creator>Bloemen, Paul R</creator><creator>van Doorn, Martijn B A</creator><creator>Velthuis, Peter</creator><creator>Aalders, Maurice C G</creator><creator>Wolkerstorfer, Albert</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240101</creationdate><title>Home-Use Hyaluronic Acid Jet Injectors: Unreliable and Unsafe</title><author>Juch, Rosalie N S ; Bik, Liora ; Boeijink, Neill ; de Vos, Judith ; Dobbe, Iwan J G G ; Bloemen, Paul R ; van Doorn, Martijn B A ; Velthuis, Peter ; Aalders, Maurice C G ; Wolkerstorfer, Albert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-e6e85d8fcf5bb3060451749a9eb92913035b0f1701989d70487571996d0999523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Administration, Cutaneous</topic><topic>Humans</topic><topic>Hyaluronic Acid - adverse effects</topic><topic>Hyaluronic Acid - metabolism</topic><topic>Injections, Jet - methods</topic><topic>Skin - metabolism</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Juch, Rosalie N S</creatorcontrib><creatorcontrib>Bik, Liora</creatorcontrib><creatorcontrib>Boeijink, Neill</creatorcontrib><creatorcontrib>de Vos, Judith</creatorcontrib><creatorcontrib>Dobbe, Iwan J G G</creatorcontrib><creatorcontrib>Bloemen, Paul R</creatorcontrib><creatorcontrib>van Doorn, Martijn B A</creatorcontrib><creatorcontrib>Velthuis, Peter</creatorcontrib><creatorcontrib>Aalders, Maurice C G</creatorcontrib><creatorcontrib>Wolkerstorfer, Albert</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatologic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Juch, Rosalie N S</au><au>Bik, Liora</au><au>Boeijink, Neill</au><au>de Vos, Judith</au><au>Dobbe, Iwan J G G</au><au>Bloemen, Paul R</au><au>van Doorn, Martijn B A</au><au>Velthuis, Peter</au><au>Aalders, Maurice C G</au><au>Wolkerstorfer, Albert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Home-Use Hyaluronic Acid Jet Injectors: Unreliable and Unsafe</atitle><jtitle>Dermatologic surgery</jtitle><addtitle>Dermatol Surg</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>50</volume><issue>1</issue><spage>62</spage><epage>68</epage><pages>62-68</pages><issn>1076-0512</issn><eissn>1524-4725</eissn><abstract>Needle-free hyaluronic acid (HA) jet injectors are gaining popularity for rejuvenation treatment. The devices are widely available online and are used for self-injection or in beauty salons by nonphysicians. However, little is known about their performance and safety.
To explore the injection efficiency and cutaneous biodistribution patterns administered with home-use compared with medical jet injectors and to assess safety aspects.
The authors injected HA into ex vivo human skin with 4 home-use and 2 medical injectors. The intracutaneous dose of HA was calculated, and the cutaneous biodistribution of HA was assessed using a 3-dimensional Fluorescent Imaging Cryomicrotome System (3D-FICS). Safety aspects were evaluated based on the presence of a manual, CE (conformité européenne) mark, and sterility.
The intracutaneous dose delivered by the home-use injectors was markedly lower compared with the medical injectors. 3D imaging for home-use injectors showed superficial epidermal distribution with low distribution volumes. For medical injectors, volumes were substantially larger and mainly middermal. All evaluated safety aspects were lacking.
Results of this study suggest that the specific combinations of home-use injectors and HA used in this study are unreliable and unsafe, which casts doubts on the performance of these treatments in general.</abstract><cop>United States</cop><pmid>37815475</pmid><doi>10.1097/DSS.0000000000003971</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Administration, Cutaneous Humans Hyaluronic Acid - adverse effects Hyaluronic Acid - metabolism Injections, Jet - methods Skin - metabolism Tissue Distribution |
| title | Home-Use Hyaluronic Acid Jet Injectors: Unreliable and Unsafe |
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