The cytochrome P450 reductase CprA is a rate-limiting factor for Cyp51A-mediated azole resistance in Aspergillus fumigatus

Azole antifungals remain the "gold standard" therapy for invasive aspergillosis. The world-wide emergence of isolates resistant to this drug class, however, developed into a steadily increasing threat to human health over the past years. In , major mechanisms of resistance involve increase...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2023-11, Vol.67 (11), p.e0091823-e0091823
Hauptverfasser:	Kühbacher, Alexander, Merschak, Petra, Haas, Hubertus, Liebl, Maximilian, Müller, Christoph, Gsaller, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - metabolism Antifungal Agents - pharmacology Aspergillus fumigatus Azoles - metabolism Azoles - pharmacology Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Drug Resistance, Fungal Fungal Proteins - genetics Fungal Proteins - metabolism Humans Microbial Sensitivity Tests NADPH-Ferrihemoprotein Reductase - genetics
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