Multitargeted inhibition of key enzymes associated with diabetes and Alzheimer's disease by 1,3,4‐oxadiazole derivatives: Synthesis, in vitro screening, and computational studies

A library of 22 derivatives of 1,3,4‐oxadiazole‐2‐thiol was synthesized, structurally characterized, and assessed for its potential to inhibit α‐amylase, α‐glucosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and antioxidant activities. Most of the tested compounds demonstrated go...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2023-12, Vol.356 (12), p.e2300384-n/a
Hauptverfasser:	Fatima, Bibi, Saleem, Faiza, Salar, Uzma, Chigurupati, Sridevi, Felemban, Shatha G., Ul‐Haq, Zaheer, Tariq, Syeda S., Almahmoud, Suliman A., Taha, Muhammad, Shah, Syed T. A., Khan, Khalid M.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3,4‐Oxadiazole AChE inhibitor Alzheimer's disease BChE inhibitor Enzymes α‐amylase inhibitor α‐glucosidase inhibitor
Online-Zugang:	Volltext
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