Investigation of novel 5ʹ-amino adenosine derivatives with potential anti-Zika virus activity

The Zika virus (ZIKV) infections remains a global health threat. However, no approved drug for treating ZIKV infection. We previously found TZY12-9, a 5ʹ-amino NI analog, that showed anti-ZIKV activity without chemical phosphorylation. Here, a series of 5ʹ-amino NI analogs were synthesized and evalu...

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Veröffentlicht in:	European journal of medicinal chemistry 2023-12, Vol.261, p.115852-115852, Article 115852
Hauptverfasser:	Chen, Xingjuan, Yan, Yunzheng, Song, Huijuan, Wang, Zhuang, Wang, Apeng, Yang, Jingjing, Zhou, Rui, Xu, Shijie, Yang, Shaokang, Li, Wei, Qin, Xiaoyu, Dai, Qingsong, Liu, Mingliang, Lv, Kai, Cao, Ruiyuan, Zhong, Wu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral agents MTase Nucleoside analogs RdRp Zika virus
Online-Zugang:	Volltext
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