Prognostic significance of the systemic inflammation response index in gastrointestinal malignancy patients: a pooled analysis of 10,091 participants
We performed a meta-analysis to investigate the association of the systemic inflammation response index (SIRI) with long-term survival outcomes in patients with gastrointestinal malignancy. PubMed, Web of Science and Embase were searched for relevant studies evaluating the prognostic significance of...
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| Veröffentlicht in: | Future oncology (London, England) England), 2023-09, Vol.19 (29), p.1961-1972 |
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| container_end_page | 1972 |
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| container_issue | 29 |
| container_start_page | 1961 |
| container_title | Future oncology (London, England) |
| container_volume | 19 |
| creator | Liang, Xian-Wen Liu, Bing Yu, Hai-Jing Chen, Jia-Cheng Cao, Zhi Wang, Sheng-Zhong Wu, Jin-Cai |
| description | We performed a meta-analysis to investigate the association of the systemic inflammation response index (SIRI) with long-term survival outcomes in patients with gastrointestinal malignancy.
PubMed, Web of Science and Embase were searched for relevant studies evaluating the prognostic significance of the SIRI in gastrointestinal malignancies until May 2023.
30 studies with 10,091 patients were included. The pooled results identified that patients in the high SIRI group had a worse overall survival and disease-free survival, which was observed across various tumor types, tumor stages and primary treatments.
An elevated SIRI is negatively associated with worse survival outcomes of gastrointestinal malignancy patients and can be used as a risk stratification index for gastrointestinal malignancies. |
| doi_str_mv | 10.2217/fon-2023-0545 |
| format | Article |
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PubMed, Web of Science and Embase were searched for relevant studies evaluating the prognostic significance of the SIRI in gastrointestinal malignancies until May 2023.
30 studies with 10,091 patients were included. The pooled results identified that patients in the high SIRI group had a worse overall survival and disease-free survival, which was observed across various tumor types, tumor stages and primary treatments.
An elevated SIRI is negatively associated with worse survival outcomes of gastrointestinal malignancy patients and can be used as a risk stratification index for gastrointestinal malignancies.</description><identifier>ISSN: 1479-6694</identifier><identifier>EISSN: 1744-8301</identifier><identifier>DOI: 10.2217/fon-2023-0545</identifier><language>eng</language><publisher>Future Medicine Ltd</publisher><subject>disease-free survival ; gastrointestinal malignancy ; inflammatory biomarker ; lymphocytes ; meta-analysis ; monocytes ; neutrophils ; overall survival ; prognostic index ; systemic inflammation response index</subject><ispartof>Future oncology (London, England), 2023-09, Vol.19 (29), p.1961-1972</ispartof><rights>2023 Future Medicine Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-8d7269f4b6896108afa0a5919da8b75256b814cd863b02608a8820f1a0897a783</citedby><cites>FETCH-LOGICAL-c320t-8d7269f4b6896108afa0a5919da8b75256b814cd863b02608a8820f1a0897a783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Liang, Xian-Wen</creatorcontrib><creatorcontrib>Liu, Bing</creatorcontrib><creatorcontrib>Yu, Hai-Jing</creatorcontrib><creatorcontrib>Chen, Jia-Cheng</creatorcontrib><creatorcontrib>Cao, Zhi</creatorcontrib><creatorcontrib>Wang, Sheng-Zhong</creatorcontrib><creatorcontrib>Wu, Jin-Cai</creatorcontrib><title>Prognostic significance of the systemic inflammation response index in gastrointestinal malignancy patients: a pooled analysis of 10,091 participants</title><title>Future oncology (London, England)</title><description>We performed a meta-analysis to investigate the association of the systemic inflammation response index (SIRI) with long-term survival outcomes in patients with gastrointestinal malignancy.
PubMed, Web of Science and Embase were searched for relevant studies evaluating the prognostic significance of the SIRI in gastrointestinal malignancies until May 2023.
30 studies with 10,091 patients were included. The pooled results identified that patients in the high SIRI group had a worse overall survival and disease-free survival, which was observed across various tumor types, tumor stages and primary treatments.
An elevated SIRI is negatively associated with worse survival outcomes of gastrointestinal malignancy patients and can be used as a risk stratification index for gastrointestinal malignancies.</description><subject>disease-free survival</subject><subject>gastrointestinal malignancy</subject><subject>inflammatory biomarker</subject><subject>lymphocytes</subject><subject>meta-analysis</subject><subject>monocytes</subject><subject>neutrophils</subject><subject>overall survival</subject><subject>prognostic index</subject><subject>systemic inflammation response index</subject><issn>1479-6694</issn><issn>1744-8301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kE2PFCEQhjtGE9fVo3eOHmwFmubDm9m4arKJHvRMamgYMd3QUkzi_BD_rzUZr174fOqleIbhpeBvpBTmbapllFxOI5_V_Gi4EUap0U5cPKa1Mm7U2qmnwzPEn5wrM838ZvjztdVjqdhzYJiPJaccoITIamL9R2R4xh43uswlrbBt0HMtrEXca8FIp0v8TSM7AvZWc-mRogqsbIOV4ijqzHYqiqXjOwZsr3WNCwNCzpjx8ozgr7kTRDVqIu9A5PPhSYIV44t_8-3w_f7Dt7tP48OXj5_v3j-MYZK8j3YxUrukDto6LbiFBBxmJ9wC9mBmOeuDFSosVk8HLjUB1kqeBHDrDBg73Q6vrrl7q79O1LrfMoa4rlBiPaGX1iipZycloeMVDa0itpj83vIG7ewF9xf9nvT7i35_0U-8u_Lp1E_kK5CCEP11t8WFvlrif2r_Aj7Zjo0</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Liang, Xian-Wen</creator><creator>Liu, Bing</creator><creator>Yu, Hai-Jing</creator><creator>Chen, Jia-Cheng</creator><creator>Cao, Zhi</creator><creator>Wang, Sheng-Zhong</creator><creator>Wu, Jin-Cai</creator><general>Future Medicine Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230901</creationdate><title>Prognostic significance of the systemic inflammation response index in gastrointestinal malignancy patients: a pooled analysis of 10,091 participants</title><author>Liang, Xian-Wen ; Liu, Bing ; Yu, Hai-Jing ; Chen, Jia-Cheng ; Cao, Zhi ; Wang, Sheng-Zhong ; Wu, Jin-Cai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-8d7269f4b6896108afa0a5919da8b75256b814cd863b02608a8820f1a0897a783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>disease-free survival</topic><topic>gastrointestinal malignancy</topic><topic>inflammatory biomarker</topic><topic>lymphocytes</topic><topic>meta-analysis</topic><topic>monocytes</topic><topic>neutrophils</topic><topic>overall survival</topic><topic>prognostic index</topic><topic>systemic inflammation response index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Xian-Wen</creatorcontrib><creatorcontrib>Liu, Bing</creatorcontrib><creatorcontrib>Yu, Hai-Jing</creatorcontrib><creatorcontrib>Chen, Jia-Cheng</creatorcontrib><creatorcontrib>Cao, Zhi</creatorcontrib><creatorcontrib>Wang, Sheng-Zhong</creatorcontrib><creatorcontrib>Wu, Jin-Cai</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Future oncology (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Xian-Wen</au><au>Liu, Bing</au><au>Yu, Hai-Jing</au><au>Chen, Jia-Cheng</au><au>Cao, Zhi</au><au>Wang, Sheng-Zhong</au><au>Wu, Jin-Cai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of the systemic inflammation response index in gastrointestinal malignancy patients: a pooled analysis of 10,091 participants</atitle><jtitle>Future oncology (London, England)</jtitle><date>2023-09-01</date><risdate>2023</risdate><volume>19</volume><issue>29</issue><spage>1961</spage><epage>1972</epage><pages>1961-1972</pages><issn>1479-6694</issn><eissn>1744-8301</eissn><abstract>We performed a meta-analysis to investigate the association of the systemic inflammation response index (SIRI) with long-term survival outcomes in patients with gastrointestinal malignancy.
PubMed, Web of Science and Embase were searched for relevant studies evaluating the prognostic significance of the SIRI in gastrointestinal malignancies until May 2023.
30 studies with 10,091 patients were included. The pooled results identified that patients in the high SIRI group had a worse overall survival and disease-free survival, which was observed across various tumor types, tumor stages and primary treatments.
An elevated SIRI is negatively associated with worse survival outcomes of gastrointestinal malignancy patients and can be used as a risk stratification index for gastrointestinal malignancies.</abstract><pub>Future Medicine Ltd</pub><doi>10.2217/fon-2023-0545</doi><tpages>12</tpages></addata></record> |
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| ispartof | Future oncology (London, England), 2023-09, Vol.19 (29), p.1961-1972 |
| issn | 1479-6694 1744-8301 |
| language | eng |
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| source | PubMed Central |
| subjects | disease-free survival gastrointestinal malignancy inflammatory biomarker lymphocytes meta-analysis monocytes neutrophils overall survival prognostic index systemic inflammation response index |
| title | Prognostic significance of the systemic inflammation response index in gastrointestinal malignancy patients: a pooled analysis of 10,091 participants |
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