Cyanoacrylate mesh fixation for laparoscopic inguinal hernia repair: a prospective, multicenter, single-arm study
Background Inguinal hernia repair is among the most frequently performed surgical procedures. Alternatives to penetrating mesh fixation, such as surgical glue, are being investigated for their potential benefit in reducing chronic pain. The aim of this study was to assess the efficacy of the n -hexy...
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creator | Dams, Anne Vankeirsbilck, Joost Poelmans, Stephan Kerschaever, Ivan Borreman, Philippe Berwouts, Luc De Mulder, Wim Colle, Julien Beunis, Anthony Dhooghe, Vicky Van De Winkel, Nele Allaeys, Mathias Ruyssers, Michael Haesen, Dorien Van der Speeten, Kurt |
description | Background
Inguinal hernia repair is among the most frequently performed surgical procedures. Alternatives to penetrating mesh fixation, such as surgical glue, are being investigated for their potential benefit in reducing chronic pain. The aim of this study was to assess the efficacy of the
n
-hexyl cyanoacrylate glue Ifabond™ for mesh fixation in laparoscopic inguinal hernia repair.
Methods
This prospective, multicenter, single-arm study collected data from laparoscopic inguinal hernia repairs using Ifabond™ (Peters Surgical, Boulogne-Billancourt Cedex, France) and a standard [Promesh® SURG ST (Peters Surgical)/Biomesh® P1 (Cousin Biotech, Wervicq-Sud, France)] or lightweight [Promesh® SURG LI (Peters Surgical)/Premium® Implant (Cousin Biotech)] polypropylene mesh. The primary endpoint was postoperative pain [100-scale Visual Analog Scale (VAS)]. Secondary endpoints were complications, hernia recurrences, and quality of life (QoL) (EQ-5D-3L health index and EQ-VAS). Patients were followed up at 5 weeks and 12 months after surgery.
Results
Six-hundred and thirteen patients underwent laparoscopic inguinal hernia repair. Postoperative pain decreased at 5-week (3.97 ± 10.04;
p
|
doi_str_mv | 10.1007/s00464-023-10439-6 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2874260028</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2874260028</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-6c2c7bac9a02bce95709eed5c6ac97a570db0cc717c2b62f5f93ebd4114264fd3</originalsourceid><addsrcrecordid>eNp9kU1PFTEUhhuikQv6B1yYJm5YUGlPZ6ZTd-ZG0ISEDaybM50zUDJftDOG--8pXsTEhaum7fO-7cnD2EclvygpzVmSsqgKIUELJQttRXXANqrQIABU_YZtpNVSgLHFITtK6V5m3qryHTvUxti6BLthD9sdjhP6uOtxIT5QuuNdeMQlTCPvpsh7nDFOyU9z8DyMt2sYsed3FMeAPNKMIX7lyOfMzOSX8ItO-bD2S_A0LhRPecqhngTGgadlbXfv2dsO-0QfXtZjdnP-_Xr7Q1xeXfzcfrsUXkO1iMqDNw16ixIaT7Y00hK1pa_ymcG8bRvpvVHGQ1NBV3ZWU9MWShVQFV2rj9nJvjd_7WGltLghJE99jyNNa3JQm0xKCXVGP_-D3k9rzHM-U9aWCmqwmYI95fOsKVLn5hgGjDunpHsW4vZCXBbifgtxVQ59eqlem4Ha18gfAxnQeyDlq_GW4t-3_1P7BF5gmEQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2899512829</pqid></control><display><type>article</type><title>Cyanoacrylate mesh fixation for laparoscopic inguinal hernia repair: a prospective, multicenter, single-arm study</title><source>SpringerNature Journals</source><creator>Dams, Anne ; Vankeirsbilck, Joost ; Poelmans, Stephan ; Kerschaever, Ivan ; Borreman, Philippe ; Berwouts, Luc ; De Mulder, Wim ; Colle, Julien ; Beunis, Anthony ; Dhooghe, Vicky ; Van De Winkel, Nele ; Allaeys, Mathias ; Ruyssers, Michael ; Haesen, Dorien ; Van der Speeten, Kurt</creator><creatorcontrib>Dams, Anne ; Vankeirsbilck, Joost ; Poelmans, Stephan ; Kerschaever, Ivan ; Borreman, Philippe ; Berwouts, Luc ; De Mulder, Wim ; Colle, Julien ; Beunis, Anthony ; Dhooghe, Vicky ; Van De Winkel, Nele ; Allaeys, Mathias ; Ruyssers, Michael ; Haesen, Dorien ; Van der Speeten, Kurt</creatorcontrib><description><![CDATA[Background
Inguinal hernia repair is among the most frequently performed surgical procedures. Alternatives to penetrating mesh fixation, such as surgical glue, are being investigated for their potential benefit in reducing chronic pain. The aim of this study was to assess the efficacy of the
n
-hexyl cyanoacrylate glue Ifabond™ for mesh fixation in laparoscopic inguinal hernia repair.
Methods
This prospective, multicenter, single-arm study collected data from laparoscopic inguinal hernia repairs using Ifabond™ (Peters Surgical, Boulogne-Billancourt Cedex, France) and a standard [Promesh® SURG ST (Peters Surgical)/Biomesh® P1 (Cousin Biotech, Wervicq-Sud, France)] or lightweight [Promesh® SURG LI (Peters Surgical)/Premium® Implant (Cousin Biotech)] polypropylene mesh. The primary endpoint was postoperative pain [100-scale Visual Analog Scale (VAS)]. Secondary endpoints were complications, hernia recurrences, and quality of life (QoL) (EQ-5D-3L health index and EQ-VAS). Patients were followed up at 5 weeks and 12 months after surgery.
Results
Six-hundred and thirteen patients underwent laparoscopic inguinal hernia repair. Postoperative pain decreased at 5-week (3.97 ± 10.04;
p
< 0.0001) and 12-month (3.83 ± 11.26;
p
< 0.0001) follow-up compared with before surgery (26.96 ± 19.42). One hundred and fifteen patients (13.74%) experienced chronic pain in the groin at 12-month follow-up, of whom 14 (2.67%) required analgesics. There were 6 patients with major morbidities and one patient died of an unrelated cause. Two hernia recurrences occurred within 12-month follow-up. Patients’ QoL increased from an EQ-5D-3L index score of 0.82 ± 0.19 preoperatively to 0.90 ± 0.15 at 5 weeks (
p
< 0.0001) and 0.92 ± 0.15 at 12 months after surgery (
p
< 0.0001). The EQ-VAS general health scoring increased from 79.03 ± 12.69 preoperatively to 84.31 ± 9.97 at 5-week (
p
< 0.0001) and 84.16 ± 14.48 at 12-month follow-up (
p
< 0.0001).
Conclusions
Ifabond™ (Peters Surgical) is a safe, reliable, and feasible fixation method for laparoscopic inguinal hernia repair with a very high surgeon satisfaction score, improved patients’ QoL, and comparable risk of developing chronic pain and postoperative complications as described in the literature.]]></description><identifier>ISSN: 0930-2794</identifier><identifier>EISSN: 1432-2218</identifier><identifier>DOI: 10.1007/s00464-023-10439-6</identifier><identifier>PMID: 37798529</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abdominal Surgery ; Chronic pain ; Gastroenterology ; Gynecology ; Hepatology ; Hernias ; Laparoscopy ; Medicine ; Medicine & Public Health ; Proctology ; Surgery ; Surgical mesh ; Surgical outcomes</subject><ispartof>Surgical endoscopy, 2023-12, Vol.37 (12), p.9105-9115</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-6c2c7bac9a02bce95709eed5c6ac97a570db0cc717c2b62f5f93ebd4114264fd3</cites><orcidid>0000-0001-8899-7834</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00464-023-10439-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00464-023-10439-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37798529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dams, Anne</creatorcontrib><creatorcontrib>Vankeirsbilck, Joost</creatorcontrib><creatorcontrib>Poelmans, Stephan</creatorcontrib><creatorcontrib>Kerschaever, Ivan</creatorcontrib><creatorcontrib>Borreman, Philippe</creatorcontrib><creatorcontrib>Berwouts, Luc</creatorcontrib><creatorcontrib>De Mulder, Wim</creatorcontrib><creatorcontrib>Colle, Julien</creatorcontrib><creatorcontrib>Beunis, Anthony</creatorcontrib><creatorcontrib>Dhooghe, Vicky</creatorcontrib><creatorcontrib>Van De Winkel, Nele</creatorcontrib><creatorcontrib>Allaeys, Mathias</creatorcontrib><creatorcontrib>Ruyssers, Michael</creatorcontrib><creatorcontrib>Haesen, Dorien</creatorcontrib><creatorcontrib>Van der Speeten, Kurt</creatorcontrib><title>Cyanoacrylate mesh fixation for laparoscopic inguinal hernia repair: a prospective, multicenter, single-arm study</title><title>Surgical endoscopy</title><addtitle>Surg Endosc</addtitle><addtitle>Surg Endosc</addtitle><description><![CDATA[Background
Inguinal hernia repair is among the most frequently performed surgical procedures. Alternatives to penetrating mesh fixation, such as surgical glue, are being investigated for their potential benefit in reducing chronic pain. The aim of this study was to assess the efficacy of the
n
-hexyl cyanoacrylate glue Ifabond™ for mesh fixation in laparoscopic inguinal hernia repair.
Methods
This prospective, multicenter, single-arm study collected data from laparoscopic inguinal hernia repairs using Ifabond™ (Peters Surgical, Boulogne-Billancourt Cedex, France) and a standard [Promesh® SURG ST (Peters Surgical)/Biomesh® P1 (Cousin Biotech, Wervicq-Sud, France)] or lightweight [Promesh® SURG LI (Peters Surgical)/Premium® Implant (Cousin Biotech)] polypropylene mesh. The primary endpoint was postoperative pain [100-scale Visual Analog Scale (VAS)]. Secondary endpoints were complications, hernia recurrences, and quality of life (QoL) (EQ-5D-3L health index and EQ-VAS). Patients were followed up at 5 weeks and 12 months after surgery.
Results
Six-hundred and thirteen patients underwent laparoscopic inguinal hernia repair. Postoperative pain decreased at 5-week (3.97 ± 10.04;
p
< 0.0001) and 12-month (3.83 ± 11.26;
p
< 0.0001) follow-up compared with before surgery (26.96 ± 19.42). One hundred and fifteen patients (13.74%) experienced chronic pain in the groin at 12-month follow-up, of whom 14 (2.67%) required analgesics. There were 6 patients with major morbidities and one patient died of an unrelated cause. Two hernia recurrences occurred within 12-month follow-up. Patients’ QoL increased from an EQ-5D-3L index score of 0.82 ± 0.19 preoperatively to 0.90 ± 0.15 at 5 weeks (
p
< 0.0001) and 0.92 ± 0.15 at 12 months after surgery (
p
< 0.0001). The EQ-VAS general health scoring increased from 79.03 ± 12.69 preoperatively to 84.31 ± 9.97 at 5-week (
p
< 0.0001) and 84.16 ± 14.48 at 12-month follow-up (
p
< 0.0001).
Conclusions
Ifabond™ (Peters Surgical) is a safe, reliable, and feasible fixation method for laparoscopic inguinal hernia repair with a very high surgeon satisfaction score, improved patients’ QoL, and comparable risk of developing chronic pain and postoperative complications as described in the literature.]]></description><subject>Abdominal Surgery</subject><subject>Chronic pain</subject><subject>Gastroenterology</subject><subject>Gynecology</subject><subject>Hepatology</subject><subject>Hernias</subject><subject>Laparoscopy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Proctology</subject><subject>Surgery</subject><subject>Surgical mesh</subject><subject>Surgical outcomes</subject><issn>0930-2794</issn><issn>1432-2218</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1PFTEUhhuikQv6B1yYJm5YUGlPZ6ZTd-ZG0ISEDaybM50zUDJftDOG--8pXsTEhaum7fO-7cnD2EclvygpzVmSsqgKIUELJQttRXXANqrQIABU_YZtpNVSgLHFITtK6V5m3qryHTvUxti6BLthD9sdjhP6uOtxIT5QuuNdeMQlTCPvpsh7nDFOyU9z8DyMt2sYsed3FMeAPNKMIX7lyOfMzOSX8ItO-bD2S_A0LhRPecqhngTGgadlbXfv2dsO-0QfXtZjdnP-_Xr7Q1xeXfzcfrsUXkO1iMqDNw16ixIaT7Y00hK1pa_ymcG8bRvpvVHGQ1NBV3ZWU9MWShVQFV2rj9nJvjd_7WGltLghJE99jyNNa3JQm0xKCXVGP_-D3k9rzHM-U9aWCmqwmYI95fOsKVLn5hgGjDunpHsW4vZCXBbifgtxVQ59eqlem4Ha18gfAxnQeyDlq_GW4t-3_1P7BF5gmEQ</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Dams, Anne</creator><creator>Vankeirsbilck, Joost</creator><creator>Poelmans, Stephan</creator><creator>Kerschaever, Ivan</creator><creator>Borreman, Philippe</creator><creator>Berwouts, Luc</creator><creator>De Mulder, Wim</creator><creator>Colle, Julien</creator><creator>Beunis, Anthony</creator><creator>Dhooghe, Vicky</creator><creator>Van De Winkel, Nele</creator><creator>Allaeys, Mathias</creator><creator>Ruyssers, Michael</creator><creator>Haesen, Dorien</creator><creator>Van der Speeten, Kurt</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8899-7834</orcidid></search><sort><creationdate>20231201</creationdate><title>Cyanoacrylate mesh fixation for laparoscopic inguinal hernia repair: a prospective, multicenter, single-arm study</title><author>Dams, Anne ; Vankeirsbilck, Joost ; Poelmans, Stephan ; Kerschaever, Ivan ; Borreman, Philippe ; Berwouts, Luc ; De Mulder, Wim ; Colle, Julien ; Beunis, Anthony ; Dhooghe, Vicky ; Van De Winkel, Nele ; Allaeys, Mathias ; Ruyssers, Michael ; Haesen, Dorien ; Van der Speeten, Kurt</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-6c2c7bac9a02bce95709eed5c6ac97a570db0cc717c2b62f5f93ebd4114264fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abdominal Surgery</topic><topic>Chronic pain</topic><topic>Gastroenterology</topic><topic>Gynecology</topic><topic>Hepatology</topic><topic>Hernias</topic><topic>Laparoscopy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Proctology</topic><topic>Surgery</topic><topic>Surgical mesh</topic><topic>Surgical outcomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dams, Anne</creatorcontrib><creatorcontrib>Vankeirsbilck, Joost</creatorcontrib><creatorcontrib>Poelmans, Stephan</creatorcontrib><creatorcontrib>Kerschaever, Ivan</creatorcontrib><creatorcontrib>Borreman, Philippe</creatorcontrib><creatorcontrib>Berwouts, Luc</creatorcontrib><creatorcontrib>De Mulder, Wim</creatorcontrib><creatorcontrib>Colle, Julien</creatorcontrib><creatorcontrib>Beunis, Anthony</creatorcontrib><creatorcontrib>Dhooghe, Vicky</creatorcontrib><creatorcontrib>Van De Winkel, Nele</creatorcontrib><creatorcontrib>Allaeys, Mathias</creatorcontrib><creatorcontrib>Ruyssers, Michael</creatorcontrib><creatorcontrib>Haesen, Dorien</creatorcontrib><creatorcontrib>Van der Speeten, Kurt</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dams, Anne</au><au>Vankeirsbilck, Joost</au><au>Poelmans, Stephan</au><au>Kerschaever, Ivan</au><au>Borreman, Philippe</au><au>Berwouts, Luc</au><au>De Mulder, Wim</au><au>Colle, Julien</au><au>Beunis, Anthony</au><au>Dhooghe, Vicky</au><au>Van De Winkel, Nele</au><au>Allaeys, Mathias</au><au>Ruyssers, Michael</au><au>Haesen, Dorien</au><au>Van der Speeten, Kurt</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyanoacrylate mesh fixation for laparoscopic inguinal hernia repair: a prospective, multicenter, single-arm study</atitle><jtitle>Surgical endoscopy</jtitle><stitle>Surg Endosc</stitle><addtitle>Surg Endosc</addtitle><date>2023-12-01</date><risdate>2023</risdate><volume>37</volume><issue>12</issue><spage>9105</spage><epage>9115</epage><pages>9105-9115</pages><issn>0930-2794</issn><eissn>1432-2218</eissn><abstract><![CDATA[Background
Inguinal hernia repair is among the most frequently performed surgical procedures. Alternatives to penetrating mesh fixation, such as surgical glue, are being investigated for their potential benefit in reducing chronic pain. The aim of this study was to assess the efficacy of the
n
-hexyl cyanoacrylate glue Ifabond™ for mesh fixation in laparoscopic inguinal hernia repair.
Methods
This prospective, multicenter, single-arm study collected data from laparoscopic inguinal hernia repairs using Ifabond™ (Peters Surgical, Boulogne-Billancourt Cedex, France) and a standard [Promesh® SURG ST (Peters Surgical)/Biomesh® P1 (Cousin Biotech, Wervicq-Sud, France)] or lightweight [Promesh® SURG LI (Peters Surgical)/Premium® Implant (Cousin Biotech)] polypropylene mesh. The primary endpoint was postoperative pain [100-scale Visual Analog Scale (VAS)]. Secondary endpoints were complications, hernia recurrences, and quality of life (QoL) (EQ-5D-3L health index and EQ-VAS). Patients were followed up at 5 weeks and 12 months after surgery.
Results
Six-hundred and thirteen patients underwent laparoscopic inguinal hernia repair. Postoperative pain decreased at 5-week (3.97 ± 10.04;
p
< 0.0001) and 12-month (3.83 ± 11.26;
p
< 0.0001) follow-up compared with before surgery (26.96 ± 19.42). One hundred and fifteen patients (13.74%) experienced chronic pain in the groin at 12-month follow-up, of whom 14 (2.67%) required analgesics. There were 6 patients with major morbidities and one patient died of an unrelated cause. Two hernia recurrences occurred within 12-month follow-up. Patients’ QoL increased from an EQ-5D-3L index score of 0.82 ± 0.19 preoperatively to 0.90 ± 0.15 at 5 weeks (
p
< 0.0001) and 0.92 ± 0.15 at 12 months after surgery (
p
< 0.0001). The EQ-VAS general health scoring increased from 79.03 ± 12.69 preoperatively to 84.31 ± 9.97 at 5-week (
p
< 0.0001) and 84.16 ± 14.48 at 12-month follow-up (
p
< 0.0001).
Conclusions
Ifabond™ (Peters Surgical) is a safe, reliable, and feasible fixation method for laparoscopic inguinal hernia repair with a very high surgeon satisfaction score, improved patients’ QoL, and comparable risk of developing chronic pain and postoperative complications as described in the literature.]]></abstract><cop>New York</cop><pub>Springer US</pub><pmid>37798529</pmid><doi>10.1007/s00464-023-10439-6</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-8899-7834</orcidid></addata></record> |
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language | eng |
recordid | cdi_proquest_miscellaneous_2874260028 |
source | SpringerNature Journals |
subjects | Abdominal Surgery Chronic pain Gastroenterology Gynecology Hepatology Hernias Laparoscopy Medicine Medicine & Public Health Proctology Surgery Surgical mesh Surgical outcomes |
title | Cyanoacrylate mesh fixation for laparoscopic inguinal hernia repair: a prospective, multicenter, single-arm study |
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