Transmissibility quantification of norovirus outbreaks in 2016−2021 in Beijing, China
The transmissibility is a crucial feature for norovirus, yet its quantitative estimation has been limited. Our objective was to estimate the basic reproduction number (R0) of norovirus and investigate its variation characteristics. Norovirus outbreaks reported from September 2016 to August 2021 in B...
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| Veröffentlicht in: | Journal of medical virology 2023-10, Vol.95 (10), p.e29153-n/a |
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| creator | Wang, Yu Gao, Zhiyong Lu, Qingbin Liu, Baiwei Jia, Lei Shen, Lingyu Tian, Yi Li, Weihong Yan, Hanqiu Zhang, Daitao Yang, Peng Fang, Liqun Wang, Quanyi Cui, Fuqiang |
| description | The transmissibility is a crucial feature for norovirus, yet its quantitative estimation has been limited. Our objective was to estimate the basic reproduction number (R0) of norovirus and investigate its variation characteristics. Norovirus outbreaks reported from September 2016 to August 2021 in Beijing were analyzed. The susceptible‐infected‐removed compartment model was established to estimate R0. Linear regression models and logistic regression models were used to explore the factors affecting the transmissibility of norovirus. The overall median R0 of norovirus was estimated as 2.1 (interquartile range [IQR] 1.8–2.5), with 650 norovirus outbreaks. The transmissibility of norovirus varied by year, outbreak setting and genotype. The R0 of norovirus during September 2019 to August 2020 (median 2.1, IQR 1.8–2.4) and September 2020 to August 2021 (median 2.0, IQR 1.7–2.3) was lower than that of September 2016 to August 2017 (median 2.3, IQR 1.8–2.7) (β = 0.94, p = 0.05; β = 0.93, p = 0.008). The R0 of norovirus for all other settings was lower than that for kindergarten (median 2.4, IQR 2.0–2.9) (primary school: median 2.0, IQR 1.7–2.4, β = 0.94, p = 0.001; secondary school: median 1.7, IQR 1.5–2.0, β = 0.87, p |
| doi_str_mv | 10.1002/jmv.29153 |
| format | Article |
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Our objective was to estimate the basic reproduction number (R0) of norovirus and investigate its variation characteristics. Norovirus outbreaks reported from September 2016 to August 2021 in Beijing were analyzed. The susceptible‐infected‐removed compartment model was established to estimate R0. Linear regression models and logistic regression models were used to explore the factors affecting the transmissibility of norovirus. The overall median R0 of norovirus was estimated as 2.1 (interquartile range [IQR] 1.8–2.5), with 650 norovirus outbreaks. The transmissibility of norovirus varied by year, outbreak setting and genotype. The R0 of norovirus during September 2019 to August 2020 (median 2.1, IQR 1.8–2.4) and September 2020 to August 2021 (median 2.0, IQR 1.7–2.3) was lower than that of September 2016 to August 2017 (median 2.3, IQR 1.8–2.7) (β = 0.94, p = 0.05; β = 0.93, p = 0.008). The R0 of norovirus for all other settings was lower than that for kindergarten (median 2.4, IQR 2.0–2.9) (primary school: median 2.0, IQR 1.7–2.4, β = 0.94, p = 0.001; secondary school: median 1.7, IQR 1.5–2.0, β = 0.87, p < 0.001; college: median 1.7, IQR 1.5–1.8, β = 0.89, p = 0.03; other closed settings: median 1.8, IQR 1.5–2.0, β = 0.90, p = 0.004). GⅡ.2[P16] outbreaks had a median R0 of 2.2 (IQR 1.8–2.7), which was higher than that for GⅡ.6[P7] outbreaks (median 1.8, IQR: 1.8–2.0, odds ratio = 0.19, p = 0.03; GⅡ.2[P16] as reference) and mixed‐genotype outbreaks (median 1.7, IQR: 1.5–1.8, β = 0.92, p = 0.02; mixed‐genotype as reference). In kindergartens and primary schools, norovirus shows increased transmissibility, emphasizing the vulnerable population and high‐risk settings. Furthermore, the transmissibility of norovirus may change over time and with virus evolution, necessitating additional research to uncover the underlying mechanisms.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.29153</identifier><language>eng</language><subject>basic reproduction number (R0) ; epidemiology ; genotype ; norovirus ; outbreaks</subject><ispartof>Journal of medical virology, 2023-10, Vol.95 (10), p.e29153-n/a</ispartof><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2623-311f2a9f73c8a7dbd398e493b824c36d2d11158902f2d5acfe113e50677de1d93</cites><orcidid>0000-0002-0831-6275 ; 0000-0003-4413-4265 ; 0000-0002-4981-1483 ; 0000-0002-9592-4286 ; 0000-0001-9552-2503 ; 0000-0002-2804-0827</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.29153$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.29153$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids></links><search><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Gao, Zhiyong</creatorcontrib><creatorcontrib>Lu, Qingbin</creatorcontrib><creatorcontrib>Liu, Baiwei</creatorcontrib><creatorcontrib>Jia, Lei</creatorcontrib><creatorcontrib>Shen, Lingyu</creatorcontrib><creatorcontrib>Tian, Yi</creatorcontrib><creatorcontrib>Li, Weihong</creatorcontrib><creatorcontrib>Yan, Hanqiu</creatorcontrib><creatorcontrib>Zhang, Daitao</creatorcontrib><creatorcontrib>Yang, Peng</creatorcontrib><creatorcontrib>Fang, Liqun</creatorcontrib><creatorcontrib>Wang, Quanyi</creatorcontrib><creatorcontrib>Cui, Fuqiang</creatorcontrib><title>Transmissibility quantification of norovirus outbreaks in 2016−2021 in Beijing, China</title><title>Journal of medical virology</title><description>The transmissibility is a crucial feature for norovirus, yet its quantitative estimation has been limited. Our objective was to estimate the basic reproduction number (R0) of norovirus and investigate its variation characteristics. Norovirus outbreaks reported from September 2016 to August 2021 in Beijing were analyzed. The susceptible‐infected‐removed compartment model was established to estimate R0. Linear regression models and logistic regression models were used to explore the factors affecting the transmissibility of norovirus. The overall median R0 of norovirus was estimated as 2.1 (interquartile range [IQR] 1.8–2.5), with 650 norovirus outbreaks. The transmissibility of norovirus varied by year, outbreak setting and genotype. The R0 of norovirus during September 2019 to August 2020 (median 2.1, IQR 1.8–2.4) and September 2020 to August 2021 (median 2.0, IQR 1.7–2.3) was lower than that of September 2016 to August 2017 (median 2.3, IQR 1.8–2.7) (β = 0.94, p = 0.05; β = 0.93, p = 0.008). The R0 of norovirus for all other settings was lower than that for kindergarten (median 2.4, IQR 2.0–2.9) (primary school: median 2.0, IQR 1.7–2.4, β = 0.94, p = 0.001; secondary school: median 1.7, IQR 1.5–2.0, β = 0.87, p < 0.001; college: median 1.7, IQR 1.5–1.8, β = 0.89, p = 0.03; other closed settings: median 1.8, IQR 1.5–2.0, β = 0.90, p = 0.004). GⅡ.2[P16] outbreaks had a median R0 of 2.2 (IQR 1.8–2.7), which was higher than that for GⅡ.6[P7] outbreaks (median 1.8, IQR: 1.8–2.0, odds ratio = 0.19, p = 0.03; GⅡ.2[P16] as reference) and mixed‐genotype outbreaks (median 1.7, IQR: 1.5–1.8, β = 0.92, p = 0.02; mixed‐genotype as reference). In kindergartens and primary schools, norovirus shows increased transmissibility, emphasizing the vulnerable population and high‐risk settings. Furthermore, the transmissibility of norovirus may change over time and with virus evolution, necessitating additional research to uncover the underlying mechanisms.</description><subject>basic reproduction number (R0)</subject><subject>epidemiology</subject><subject>genotype</subject><subject>norovirus</subject><subject>outbreaks</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kE1OwzAQhS0EEqWw4AZZgkRaz7hx4iVU_KqITYGl5SQ2uKROsZOi3oA1R-QkpIQtq9GTvvek-Qg5BjoCSnG8WK5HKCBhO2QAVPBY0BR2yYDChMecQ7JPDkJYUEozgTggz3OvXFjaEGxuK9tsovdWucYaW6jG1i6qTeRqX6-tb0NUt03utXoLkXURUuDfn19IEbbxQtuFdS9n0fTVOnVI9oyqgj76u0PyeHU5n97Es4fr2-n5LC6QI4sZgEElTMqKTKVlXjKR6YlgeYaTgvESSwBIMkHRYJmowmgAphPK07TUUAo2JCf97srX760Ojex-KXRVKafrNkjM0gkmGeO8Q097tPB1CF4bufJ2qfxGApVbebKTJ3_ldey4Zz9spTf_g_Lu_qlv_AA-a3DN</recordid><startdate>202310</startdate><enddate>202310</enddate><creator>Wang, Yu</creator><creator>Gao, Zhiyong</creator><creator>Lu, Qingbin</creator><creator>Liu, Baiwei</creator><creator>Jia, Lei</creator><creator>Shen, Lingyu</creator><creator>Tian, Yi</creator><creator>Li, Weihong</creator><creator>Yan, Hanqiu</creator><creator>Zhang, Daitao</creator><creator>Yang, Peng</creator><creator>Fang, Liqun</creator><creator>Wang, Quanyi</creator><creator>Cui, Fuqiang</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0831-6275</orcidid><orcidid>https://orcid.org/0000-0003-4413-4265</orcidid><orcidid>https://orcid.org/0000-0002-4981-1483</orcidid><orcidid>https://orcid.org/0000-0002-9592-4286</orcidid><orcidid>https://orcid.org/0000-0001-9552-2503</orcidid><orcidid>https://orcid.org/0000-0002-2804-0827</orcidid></search><sort><creationdate>202310</creationdate><title>Transmissibility quantification of norovirus outbreaks in 2016−2021 in Beijing, China</title><author>Wang, Yu ; Gao, Zhiyong ; Lu, Qingbin ; Liu, Baiwei ; Jia, Lei ; Shen, Lingyu ; Tian, Yi ; Li, Weihong ; Yan, Hanqiu ; Zhang, Daitao ; Yang, Peng ; Fang, Liqun ; Wang, Quanyi ; Cui, Fuqiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2623-311f2a9f73c8a7dbd398e493b824c36d2d11158902f2d5acfe113e50677de1d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>basic reproduction number (R0)</topic><topic>epidemiology</topic><topic>genotype</topic><topic>norovirus</topic><topic>outbreaks</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Gao, Zhiyong</creatorcontrib><creatorcontrib>Lu, Qingbin</creatorcontrib><creatorcontrib>Liu, Baiwei</creatorcontrib><creatorcontrib>Jia, Lei</creatorcontrib><creatorcontrib>Shen, Lingyu</creatorcontrib><creatorcontrib>Tian, Yi</creatorcontrib><creatorcontrib>Li, Weihong</creatorcontrib><creatorcontrib>Yan, Hanqiu</creatorcontrib><creatorcontrib>Zhang, Daitao</creatorcontrib><creatorcontrib>Yang, Peng</creatorcontrib><creatorcontrib>Fang, Liqun</creatorcontrib><creatorcontrib>Wang, Quanyi</creatorcontrib><creatorcontrib>Cui, Fuqiang</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yu</au><au>Gao, Zhiyong</au><au>Lu, Qingbin</au><au>Liu, Baiwei</au><au>Jia, Lei</au><au>Shen, Lingyu</au><au>Tian, Yi</au><au>Li, Weihong</au><au>Yan, Hanqiu</au><au>Zhang, Daitao</au><au>Yang, Peng</au><au>Fang, Liqun</au><au>Wang, Quanyi</au><au>Cui, Fuqiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transmissibility quantification of norovirus outbreaks in 2016−2021 in Beijing, China</atitle><jtitle>Journal of medical virology</jtitle><date>2023-10</date><risdate>2023</risdate><volume>95</volume><issue>10</issue><spage>e29153</spage><epage>n/a</epage><pages>e29153-n/a</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>The transmissibility is a crucial feature for norovirus, yet its quantitative estimation has been limited. Our objective was to estimate the basic reproduction number (R0) of norovirus and investigate its variation characteristics. Norovirus outbreaks reported from September 2016 to August 2021 in Beijing were analyzed. The susceptible‐infected‐removed compartment model was established to estimate R0. Linear regression models and logistic regression models were used to explore the factors affecting the transmissibility of norovirus. The overall median R0 of norovirus was estimated as 2.1 (interquartile range [IQR] 1.8–2.5), with 650 norovirus outbreaks. The transmissibility of norovirus varied by year, outbreak setting and genotype. The R0 of norovirus during September 2019 to August 2020 (median 2.1, IQR 1.8–2.4) and September 2020 to August 2021 (median 2.0, IQR 1.7–2.3) was lower than that of September 2016 to August 2017 (median 2.3, IQR 1.8–2.7) (β = 0.94, p = 0.05; β = 0.93, p = 0.008). The R0 of norovirus for all other settings was lower than that for kindergarten (median 2.4, IQR 2.0–2.9) (primary school: median 2.0, IQR 1.7–2.4, β = 0.94, p = 0.001; secondary school: median 1.7, IQR 1.5–2.0, β = 0.87, p < 0.001; college: median 1.7, IQR 1.5–1.8, β = 0.89, p = 0.03; other closed settings: median 1.8, IQR 1.5–2.0, β = 0.90, p = 0.004). GⅡ.2[P16] outbreaks had a median R0 of 2.2 (IQR 1.8–2.7), which was higher than that for GⅡ.6[P7] outbreaks (median 1.8, IQR: 1.8–2.0, odds ratio = 0.19, p = 0.03; GⅡ.2[P16] as reference) and mixed‐genotype outbreaks (median 1.7, IQR: 1.5–1.8, β = 0.92, p = 0.02; mixed‐genotype as reference). In kindergartens and primary schools, norovirus shows increased transmissibility, emphasizing the vulnerable population and high‐risk settings. Furthermore, the transmissibility of norovirus may change over time and with virus evolution, necessitating additional research to uncover the underlying mechanisms.</abstract><doi>10.1002/jmv.29153</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-0831-6275</orcidid><orcidid>https://orcid.org/0000-0003-4413-4265</orcidid><orcidid>https://orcid.org/0000-0002-4981-1483</orcidid><orcidid>https://orcid.org/0000-0002-9592-4286</orcidid><orcidid>https://orcid.org/0000-0001-9552-2503</orcidid><orcidid>https://orcid.org/0000-0002-2804-0827</orcidid></addata></record> |
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| subjects | basic reproduction number (R0) epidemiology genotype norovirus outbreaks |
| title | Transmissibility quantification of norovirus outbreaks in 2016−2021 in Beijing, China |
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