The E3 ligase Trim63 promotes podocyte injury and proteinuria by targeting PPARα to inhibit fatty acid oxidation

Podocyte injury is a hallmark of glomerular disease and one of the leading causes of chronic kidney disease (CKD). Peroxisome proliferator-activated receptor α (PPARα) plays a key role in podocyte fatty acid oxidation (FAO). However, the underlying regulatory mechanisms remain unresolved. Trim63 is...

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Veröffentlicht in:	Free radical biology & medicine 2023-11, Vol.209, p.40-54
Hauptverfasser:	Chen, Qiyan, Xie, Chao, Tang, Kaiyue, Luo, Mujin, Zhang, Zhe, Jin, Yabin, Liu, Youhua, Zhou, Lili, Kong, Yaozhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Fatty acid oxidation Mitochondrial dysfunction Podocyte injury PPARα Trim63
Online-Zugang:	Volltext
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