CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy

Anxiety manifestations and cognitive dysfunction are common sequelae in patients with sepsis-associated encephalopathy (SAE). Microglia-mediated inflammatory signaling is involved in anxiety, depression, and cognitive dysfunction during acute infection with bacterial lipopolysaccharide (LPS). Howeve...

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Veröffentlicht in:	Neuromolecular medicine 2023-12, Vol.25 (4), p.616-631
Hauptverfasser:	Qiu, Fang, Liu, Yueming, Liu, Yang, Zhao, Zhuyun, Zhou, Lile, Chen, Pengfei, Du, Yunbo, Wang, Yanmei, Sun, Huimin, Zeng, Changchun, Wang, Xiaokang, Liu, Yuqiang, Pan, Haobo, Ke, Changneng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Anxiety Behavior Biomedical and Life Sciences Biomedicine Brain injury CD137 antigen Cognitive ability Complications Cytokines Cytokines - metabolism Disease Models, Animal Encephalopathy Enzyme-linked immunosorbent assay Fc receptors Flow cytometry Fusion protein Hippocampus Humans Immunofluorescence Inflammation Internal Medicine Lipopolysaccharides Lipopolysaccharides - toxicity Male Mice Mice, Inbred C57BL Microglia Molecular modelling Neuroinflammatory Diseases Neurology Neurosciences Protein biosynthesis Sepsis Sepsis - complications Sepsis - drug therapy Sepsis - metabolism Sepsis-Associated Encephalopathy - drug therapy Sepsis-Associated Encephalopathy - metabolism Signal transduction Spatial memory Spontaneous alternation Tumor necrosis factor-α
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