The ligand-dependent suppression of TCR signaling by the immune checkpoint receptor LAG3 depends on the cytoplasmic RRFSALE motif

Lymphocyte activation gene 3 (LAG3) is an inhibitory immune checkpoint receptor that restrains autoimmune and antitumor responses, but its evolutionarily conserved cytoplasmic tail lacks classical inhibitory motifs. Major histocompatibility complex class II (MHC class II) is an established LAG3 liga...

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Veröffentlicht in:	Science signaling 2023-10, Vol.16 (805), p.eadg2610-eadg2610
Hauptverfasser:	Aigner-Radakovics, Katharina, De Sousa Linhares, Annika, Salzer, Benjamin, Lehner, Manfred, Izadi, Shiva, Castilho, Alexandra, Pickl, Winfried F., Leitner, Judith, Steinberger, Peter
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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