Evaluating the Performance of Pathogen-Targeted Positron Emission Tomography Radiotracers in a Rat Model of Vertebral Discitis-Osteomyelitis

Abstract Background Vertebral discitis-osteomyelitis (VDO) is a devastating infection of the spine that is challenging to distinguish from noninfectious mimics using computed tomography and magnetic resonance imaging. We and others have developed novel metabolism-targeted positron emission tomograph...

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Veröffentlicht in:	The Journal of infectious diseases 2023-10, Vol.228 (Supplement_4), p.S281-S290
Hauptverfasser:	Parker, Matthew F L, López-Álvarez, Marina, Alanizi, Aryn A, Luu, Justin M, Polvoy, Ilona, Sorlin, Alexandre M, Qin, Hecong, Lee, Sanghee, Rabbitt, Sarah J, Pichardo-González, Priamo A, Ordonez, Alvaro A, Blecha, Joseph, Rosenberg, Oren S, Flavell, Robert R, Engel, Joanne, Jain, Sanjay K, Ohliger, Michael A, Wilson, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminobenzoic Acid Animal models Animals Bacteria Bacterial infections Computed tomography Discitis Discitis - diagnostic imaging Escherichia coli Humans Magnetic resonance imaging Osteomyelitis Osteomyelitis - microbiology Pathogens Positron emission tomography Positron-Emission Tomography - methods Radioactive tracers Radiopharmaceuticals Rats Spine Staphylococcal Infections - diagnostic imaging Staphylococcus aureus Tomography Vertebrae
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