The CD4/CD8 ratio of infused CD19‐CAR‐T is a prognostic factor for efficacy and toxicity

Summary CD4+ and CD8+ chimeric antigen receptor T cells (CAR‐T) play different roles in the in vivo anti‐tumour response, but the role of the CD4+/CD8+ ratio among infused CAR‐T has not been clearly defined yet. We analysed leftovers from infused anti‐CD19 CAR‐T bags of 31 patients with aggressive B...

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Veröffentlicht in:	British journal of haematology 2023-11, Vol.203 (4), p.564-570
Hauptverfasser:	Galli, Eugenio, Bellesi, Silvia, Pansini, Ilaria, Di Cesare, Giacomo, Iacovelli, Camilla, Malafronte, Rosalia, Maiolo, Elena, Chiusolo, Patrizia, Sica, Simona, Sorà, Federica, Hohaus, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Apheresis CAR‐T cells CD19 antigen CD28 antigen CD4 antigen CD4/CD8 ratio CD8 antigen Chimeric antigen receptors Hematology L-Lactate dehydrogenase Lymphocytes T Lymphoma Peripheral blood phenotype prognostic factors Toxicity
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