Controllable Si–C Bond Formation from Trihydrosilanes En Route to Synthesis of 1,4-Azasilinanes with Diverse Silyl Functionalities

Controllable Si–C Bond Formation from Trihydrosilanes En Route to Synthesis of 1,4-Azasilinanes with Diverse Silyl Functionalities

A B­(C6F5)3-catalyzed controllable inter/intra-/intermolecular Si–C bond formation process has been developed from trihydrosilane and dienamide with alkenes, anilines, or aryl iodides. A variety of 1,4-azasilinanes have been generated with diverse exo-cyclic heteroleptic disubstitutions on silicon,...

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Veröffentlicht in:Organic letters 2023-10, Vol.25 (40), p.7428-7433
Hauptverfasser: Guo, Jiawei, Liu, Shunfa, Jing, Jun, Fan, Yu, Fu, Yingdong, Liu, Shiyang, Wang, Wanshu, Gao, Lu, Song, Zhenlei
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container_end_page 7433
container_issue 40
container_start_page 7428
container_title Organic letters
container_volume 25
creator Guo, Jiawei
Liu, Shunfa
Jing, Jun
Fan, Yu
Fu, Yingdong
Liu, Shiyang
Wang, Wanshu
Gao, Lu
Song, Zhenlei
description A B­(C6F5)3-catalyzed controllable inter/intra-/intermolecular Si–C bond formation process has been developed from trihydrosilane and dienamide with alkenes, anilines, or aryl iodides. A variety of 1,4-azasilinanes have been generated with diverse exo-cyclic heteroleptic disubstitutions on silicon, thereby expanding the range of silaazacyclic rings available for the discovery of silicon-containing drugs.
doi_str_mv 10.1021/acs.orglett.3c03014
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title Controllable Si–C Bond Formation from Trihydrosilanes En Route to Synthesis of 1,4-Azasilinanes with Diverse Silyl Functionalities
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