A genetic variant in gene NDUFAF4 confers the risk of non‐small cell lung cancer by perturbing hsa‐miR‐215 binding

Hsa‐microRNA‐215 (hsa‐miR‐215) plays multiple roles in carcinogenesis through regulating its target genes. Genetic variants in hsa‐miR‐215 target sites thus may affect hsa‐miR‐215‐mRNA interactions, result in altered expression of target genes and even influence cancer susceptibility. This study aim...

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Veröffentlicht in:	Molecular carcinogenesis 2024-01, Vol.63 (1), p.145-159
Hauptverfasser:	Long, Tingting, Li, Jiaoyuan, Yin, Tongxin, Liu, Ke, Wang, Yi, Long, Jieyi, Wang, Jianing, Cheng, Liming
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 3' Untranslated regions Affinity AKT protein Apoptosis Binding sites Bioinformatics Carcinogenesis Cell adhesion & migration Cell migration Complementarity Genes Genetic diversity genetic variant Health risks hsa‐miR‐215 Kinases Lung cancer miRNA NDUFAF4 Non-small cell lung carcinoma non‐small cell lung cancer Phenotyping Reporter gene Signal transduction Small cell lung carcinoma Susceptibility Transcription factors Tumors
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