Pseudogenization of the Hair-Related Genes PADI3 and S100A3 in Cetaceans and Hippopotamus amphibius
Hair-related genes in mammals play important roles in the development and maintenance of hair and other keratinous structures in mammals. The peptidyl arginine deiminase 3 ( PADI3 ) gene encodes an enzyme that catalyzes the conversion of arginine residues to citrulline. The S100 calcium binding prot...
Gespeichert in:
| Veröffentlicht in: | Journal of molecular evolution 2023-10, Vol.91 (5), p.745-760 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 760 |
|---|---|
| container_issue | 5 |
| container_start_page | 745 |
| container_title | Journal of molecular evolution |
| container_volume | 91 |
| creator | Nagasawa, Kyomi Kitano, Takashi |
| description | Hair-related genes in mammals play important roles in the development and maintenance of hair and other keratinous structures in mammals. The peptidyl arginine deiminase 3 (
PADI3
) gene encodes an enzyme that catalyzes the conversion of arginine residues to citrulline. The S100 calcium binding protein A3 (
S100A3
) gene encodes a protein that is highly expressed in the hair cuticle and contains arginine residues that are converted to citrullines by PADI enzymes. In this study, we investigated the pseudogenization events of
PADI3
and
S100A3
in cetaceans and
Hippopotamus amphibius
. We found that
PADI3
underwent three independent pseudogenization events during cetacean evolution, in baleen whales, toothed cetaceans other than
Physeter catodon
, and
P. catodon
. Notably, the entire
PADI3
gene is absent in the baleen whales. Pseudogenization of
S100A3
occurred independently in cetaceans and
H. amphibius
. Interestingly, we found that in cetaceans
S100A3
underwent pseudogenization before
PADI3
, suggesting that differential selection pressures were acting on the two genes. Our findings provide valuable insights into the molecular evolution of these genes in cetaceans and hippopotamuses, highlighting their importance for understanding the evolution of hair-related genes. |
| doi_str_mv | 10.1007/s00239-023-10133-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2872176648</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2881053147</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-84e462819c21822dce16f28eba277f5916f012e3a24d84a17ce3ef24792bd88d3</originalsourceid><addsrcrecordid>eNp9kUFPGzEQha0KVELaP8ChssSFi8EeO2vvMUohQYoEou3ZcnZnwShrb9e7h_LrMSQFiQOXZ3nmmzeWHyEngp8LzvVF4hxkybIwwYWUjH8hE6EksBc5IJPcBwZGqSNynNIj50LPSvmVHEmtjTZKTEh1m3Cs4z0G_-QGHwONDR0ekK6c79kdbt2ANV1iwERv5z-vJXWhpr_y_rmkPtAFDq5CF9JrfeW7LnZxcO2YC2334Dd-TN_IYeO2Cb_vzyn5c3X5e7Fi65vl9WK-ZpWEYmBGoSrAiLICYQDqCkXRgMGNA62bWZlvXABKB6o2ygldocQGlC5hUxtTyyk52_l2ffw7Yhps61OF260LGMdkwWgQuiiUyejpB_Qxjn3Ir8uUEXwmhdKZgh1V9TGlHhvb9b51_T8ruH2JwO4isFnsawSW56Efe-tx02L9NvL_zzMgd0DKrXCP_fvuT2yfAdU-jp0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2881053147</pqid></control><display><type>article</type><title>Pseudogenization of the Hair-Related Genes PADI3 and S100A3 in Cetaceans and Hippopotamus amphibius</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Nagasawa, Kyomi ; Kitano, Takashi</creator><creatorcontrib>Nagasawa, Kyomi ; Kitano, Takashi</creatorcontrib><description>Hair-related genes in mammals play important roles in the development and maintenance of hair and other keratinous structures in mammals. The peptidyl arginine deiminase 3 (
PADI3
) gene encodes an enzyme that catalyzes the conversion of arginine residues to citrulline. The S100 calcium binding protein A3 (
S100A3
) gene encodes a protein that is highly expressed in the hair cuticle and contains arginine residues that are converted to citrullines by PADI enzymes. In this study, we investigated the pseudogenization events of
PADI3
and
S100A3
in cetaceans and
Hippopotamus amphibius
. We found that
PADI3
underwent three independent pseudogenization events during cetacean evolution, in baleen whales, toothed cetaceans other than
Physeter catodon
, and
P. catodon
. Notably, the entire
PADI3
gene is absent in the baleen whales. Pseudogenization of
S100A3
occurred independently in cetaceans and
H. amphibius
. Interestingly, we found that in cetaceans
S100A3
underwent pseudogenization before
PADI3
, suggesting that differential selection pressures were acting on the two genes. Our findings provide valuable insights into the molecular evolution of these genes in cetaceans and hippopotamuses, highlighting their importance for understanding the evolution of hair-related genes.</description><identifier>ISSN: 0022-2844</identifier><identifier>EISSN: 1432-1432</identifier><identifier>DOI: 10.1007/s00239-023-10133-0</identifier><identifier>PMID: 37787841</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animal Genetics and Genomics ; Animals ; Aquatic mammals ; Arginine ; Arginine - metabolism ; Arginine deiminase ; Artiodactyla - metabolism ; Balaenoptera ; Biomedical and Life Sciences ; Calcium-binding protein ; Cell Biology ; Cetacea ; Citrulline ; Evolution ; Evolutionary Biology ; Evolutionary genetics ; Genes ; Hair ; Hair - metabolism ; Hippopotamus amphibius ; Life Sciences ; Mammals ; Mammals - genetics ; Microbiology ; Molecular evolution ; Plant Genetics and Genomics ; Plant Sciences ; Protein-arginine deiminase ; Proteins ; Residues ; S100 Proteins - genetics ; S100 Proteins - metabolism ; Whales ; Whales - metabolism</subject><ispartof>Journal of molecular evolution, 2023-10, Vol.91 (5), p.745-760</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-84e462819c21822dce16f28eba277f5916f012e3a24d84a17ce3ef24792bd88d3</cites><orcidid>0000-0002-7425-4084</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00239-023-10133-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00239-023-10133-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37787841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagasawa, Kyomi</creatorcontrib><creatorcontrib>Kitano, Takashi</creatorcontrib><title>Pseudogenization of the Hair-Related Genes PADI3 and S100A3 in Cetaceans and Hippopotamus amphibius</title><title>Journal of molecular evolution</title><addtitle>J Mol Evol</addtitle><addtitle>J Mol Evol</addtitle><description>Hair-related genes in mammals play important roles in the development and maintenance of hair and other keratinous structures in mammals. The peptidyl arginine deiminase 3 (
PADI3
) gene encodes an enzyme that catalyzes the conversion of arginine residues to citrulline. The S100 calcium binding protein A3 (
S100A3
) gene encodes a protein that is highly expressed in the hair cuticle and contains arginine residues that are converted to citrullines by PADI enzymes. In this study, we investigated the pseudogenization events of
PADI3
and
S100A3
in cetaceans and
Hippopotamus amphibius
. We found that
PADI3
underwent three independent pseudogenization events during cetacean evolution, in baleen whales, toothed cetaceans other than
Physeter catodon
, and
P. catodon
. Notably, the entire
PADI3
gene is absent in the baleen whales. Pseudogenization of
S100A3
occurred independently in cetaceans and
H. amphibius
. Interestingly, we found that in cetaceans
S100A3
underwent pseudogenization before
PADI3
, suggesting that differential selection pressures were acting on the two genes. Our findings provide valuable insights into the molecular evolution of these genes in cetaceans and hippopotamuses, highlighting their importance for understanding the evolution of hair-related genes.</description><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Aquatic mammals</subject><subject>Arginine</subject><subject>Arginine - metabolism</subject><subject>Arginine deiminase</subject><subject>Artiodactyla - metabolism</subject><subject>Balaenoptera</subject><subject>Biomedical and Life Sciences</subject><subject>Calcium-binding protein</subject><subject>Cell Biology</subject><subject>Cetacea</subject><subject>Citrulline</subject><subject>Evolution</subject><subject>Evolutionary Biology</subject><subject>Evolutionary genetics</subject><subject>Genes</subject><subject>Hair</subject><subject>Hair - metabolism</subject><subject>Hippopotamus amphibius</subject><subject>Life Sciences</subject><subject>Mammals</subject><subject>Mammals - genetics</subject><subject>Microbiology</subject><subject>Molecular evolution</subject><subject>Plant Genetics and Genomics</subject><subject>Plant Sciences</subject><subject>Protein-arginine deiminase</subject><subject>Proteins</subject><subject>Residues</subject><subject>S100 Proteins - genetics</subject><subject>S100 Proteins - metabolism</subject><subject>Whales</subject><subject>Whales - metabolism</subject><issn>0022-2844</issn><issn>1432-1432</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kUFPGzEQha0KVELaP8ChssSFi8EeO2vvMUohQYoEou3ZcnZnwShrb9e7h_LrMSQFiQOXZ3nmmzeWHyEngp8LzvVF4hxkybIwwYWUjH8hE6EksBc5IJPcBwZGqSNynNIj50LPSvmVHEmtjTZKTEh1m3Cs4z0G_-QGHwONDR0ekK6c79kdbt2ANV1iwERv5z-vJXWhpr_y_rmkPtAFDq5CF9JrfeW7LnZxcO2YC2334Dd-TN_IYeO2Cb_vzyn5c3X5e7Fi65vl9WK-ZpWEYmBGoSrAiLICYQDqCkXRgMGNA62bWZlvXABKB6o2ygldocQGlC5hUxtTyyk52_l2ffw7Yhps61OF260LGMdkwWgQuiiUyejpB_Qxjn3Ir8uUEXwmhdKZgh1V9TGlHhvb9b51_T8ruH2JwO4isFnsawSW56Efe-tx02L9NvL_zzMgd0DKrXCP_fvuT2yfAdU-jp0</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Nagasawa, Kyomi</creator><creator>Kitano, Takashi</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7425-4084</orcidid></search><sort><creationdate>20231001</creationdate><title>Pseudogenization of the Hair-Related Genes PADI3 and S100A3 in Cetaceans and Hippopotamus amphibius</title><author>Nagasawa, Kyomi ; Kitano, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-84e462819c21822dce16f28eba277f5916f012e3a24d84a17ce3ef24792bd88d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animal Genetics and Genomics</topic><topic>Animals</topic><topic>Aquatic mammals</topic><topic>Arginine</topic><topic>Arginine - metabolism</topic><topic>Arginine deiminase</topic><topic>Artiodactyla - metabolism</topic><topic>Balaenoptera</topic><topic>Biomedical and Life Sciences</topic><topic>Calcium-binding protein</topic><topic>Cell Biology</topic><topic>Cetacea</topic><topic>Citrulline</topic><topic>Evolution</topic><topic>Evolutionary Biology</topic><topic>Evolutionary genetics</topic><topic>Genes</topic><topic>Hair</topic><topic>Hair - metabolism</topic><topic>Hippopotamus amphibius</topic><topic>Life Sciences</topic><topic>Mammals</topic><topic>Mammals - genetics</topic><topic>Microbiology</topic><topic>Molecular evolution</topic><topic>Plant Genetics and Genomics</topic><topic>Plant Sciences</topic><topic>Protein-arginine deiminase</topic><topic>Proteins</topic><topic>Residues</topic><topic>S100 Proteins - genetics</topic><topic>S100 Proteins - metabolism</topic><topic>Whales</topic><topic>Whales - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagasawa, Kyomi</creatorcontrib><creatorcontrib>Kitano, Takashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular evolution</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagasawa, Kyomi</au><au>Kitano, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pseudogenization of the Hair-Related Genes PADI3 and S100A3 in Cetaceans and Hippopotamus amphibius</atitle><jtitle>Journal of molecular evolution</jtitle><stitle>J Mol Evol</stitle><addtitle>J Mol Evol</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>91</volume><issue>5</issue><spage>745</spage><epage>760</epage><pages>745-760</pages><issn>0022-2844</issn><eissn>1432-1432</eissn><abstract>Hair-related genes in mammals play important roles in the development and maintenance of hair and other keratinous structures in mammals. The peptidyl arginine deiminase 3 (
PADI3
) gene encodes an enzyme that catalyzes the conversion of arginine residues to citrulline. The S100 calcium binding protein A3 (
S100A3
) gene encodes a protein that is highly expressed in the hair cuticle and contains arginine residues that are converted to citrullines by PADI enzymes. In this study, we investigated the pseudogenization events of
PADI3
and
S100A3
in cetaceans and
Hippopotamus amphibius
. We found that
PADI3
underwent three independent pseudogenization events during cetacean evolution, in baleen whales, toothed cetaceans other than
Physeter catodon
, and
P. catodon
. Notably, the entire
PADI3
gene is absent in the baleen whales. Pseudogenization of
S100A3
occurred independently in cetaceans and
H. amphibius
. Interestingly, we found that in cetaceans
S100A3
underwent pseudogenization before
PADI3
, suggesting that differential selection pressures were acting on the two genes. Our findings provide valuable insights into the molecular evolution of these genes in cetaceans and hippopotamuses, highlighting their importance for understanding the evolution of hair-related genes.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37787841</pmid><doi>10.1007/s00239-023-10133-0</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-7425-4084</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-2844 |
| ispartof | Journal of molecular evolution, 2023-10, Vol.91 (5), p.745-760 |
| issn | 0022-2844 1432-1432 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2872176648 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Animal Genetics and Genomics Animals Aquatic mammals Arginine Arginine - metabolism Arginine deiminase Artiodactyla - metabolism Balaenoptera Biomedical and Life Sciences Calcium-binding protein Cell Biology Cetacea Citrulline Evolution Evolutionary Biology Evolutionary genetics Genes Hair Hair - metabolism Hippopotamus amphibius Life Sciences Mammals Mammals - genetics Microbiology Molecular evolution Plant Genetics and Genomics Plant Sciences Protein-arginine deiminase Proteins Residues S100 Proteins - genetics S100 Proteins - metabolism Whales Whales - metabolism |
| title | Pseudogenization of the Hair-Related Genes PADI3 and S100A3 in Cetaceans and Hippopotamus amphibius |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T12%3A36%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pseudogenization%20of%20the%20Hair-Related%20Genes%20PADI3%20and%20S100A3%20in%20Cetaceans%20and%20Hippopotamus%20amphibius&rft.jtitle=Journal%20of%20molecular%20evolution&rft.au=Nagasawa,%20Kyomi&rft.date=2023-10-01&rft.volume=91&rft.issue=5&rft.spage=745&rft.epage=760&rft.pages=745-760&rft.issn=0022-2844&rft.eissn=1432-1432&rft_id=info:doi/10.1007/s00239-023-10133-0&rft_dat=%3Cproquest_cross%3E2881053147%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2881053147&rft_id=info:pmid/37787841&rfr_iscdi=true |