Thymosin α1 modulated the immune landscape of COVID-19 patients revealed by single-cell RNA and TCR sequencing

•Understand Tα1 against SARS-CoV-2 infections at the level of single cell analysis.•Tα1 increase CD3+ KLRD1+ NKT, TBX21+ CD8+ NKT cell proportion in COVID-19 patients.•Tα1 stimulate the diversity of TCR clones in COVID-19 patients. The Coronavirus disease-19 (COVID-19) pandemic has posed a serious t...

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Veröffentlicht in:	International immunopharmacology 2023-11, Vol.124, p.110983-110983, Article 110983
Hauptverfasser:	Bai, Han, Liang, Liyuan, Qi, Xin, Xu, Yao, Liu, Yijia, Ren, Doudou, Cai, Zeqiong, Mao, Weikang, Wang, Xiaorui, Qin, Hongyu, Hu, Fang, Shi, Bingyin
Format:	Artikel
Sprache:	eng
Schlagworte:	COVID-19 NKT cells PBMC Single-cell RNA sequencing T cell receptor-sequencing Thymosin α1
Online-Zugang:	Volltext
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