SET-mediated epigenetic dysregulation of p53 impairs trichloroethylene-induced DNA damage response

Trichloroethylene (TCE) was a widely used industrial solvent, and now has become a major environmental pollutant. Exposure to TCE has been found to result in significant damage to the liver, leading to hepatic toxicity. In our previous study, we discovered that a histone chaperon called SET plays a...

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Veröffentlicht in:	Toxicology letters 2023-09, Vol.387, p.76-83
Hauptverfasser:	ren, Xiaohu, Ruan, Jiawen, Lan, Xuerao, Yang, Sixia, Wu, Desheng, Huang, Xinfeng, Zhang, Hongyu, Liu, Jianjun, Huang, Haiyan
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA damage response Hepatic cytotoxicity P53 SET Tri-methylation at histone H3K79 Trichloroethylene
Online-Zugang:	Volltext
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