Regulatory T cells in dominant immunologic tolerance
Regulatory T cells expressing the transcription factor forkhead box protein 3 mediate peripheral immune tolerance both to self-antigens and to the commensal flora. Their defective function due to inborn errors of immunity or acquired insults is associated with a broad range of autoimmune and immune...
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Veröffentlicht in: | Journal of allergy and clinical immunology 2024-01, Vol.153 (1), p.28-41 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Regulatory T cells expressing the transcription factor forkhead box protein 3 mediate peripheral immune tolerance both to self-antigens and to the commensal flora. Their defective function due to inborn errors of immunity or acquired insults is associated with a broad range of autoimmune and immune dysregulatory diseases. Although their function in suppressing autoimmunity and enforcing commensalism is established, a broader role for regulatory T cells in tissue repair and metabolic regulation has emerged, enabled by unique programs of tissue adaptability and specialization. In this review, we focus on the myriad roles played by regulatory T cells in immunologic tolerance and host homeostasis and the potential to harness these cells in novel therapeutic approaches to human diseases. |
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ISSN: | 0091-6749 1097-6825 |
DOI: | 10.1016/j.jaci.2023.09.025 |