Mechanisms of kidney fibrosis and routes towards therapy

Single-cell genomic studies have shed light on the complex cellular and molecular mechanisms that initiate and drive kidney fibrosis, as well as on the origin of myofibroblasts, their heterogeneity, and crosstalk with other cells.Crucial fibrosis-driving cell types that have been recently identified...

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Veröffentlicht in:	Trends in endocrinology and metabolism 2024-01, Vol.35 (1), p.31-48
Hauptverfasser:	Yamashita, Noriyuki, Kramann, Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antifibrotic therapeutics cellular crosstalk chronic kidney disease Epithelial Cells Fibrosis Humans Kidney - pathology kidney fibrosis Mice Myofibroblasts - pathology Renal Insufficiency, Chronic single-cell RNA sequencing spatial transcriptomics
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