Real-world effectiveness of sotrovimab for the treatment of SARS-CoV-2 infection during Omicron BA.2 subvariant predominance: a systematic literature review

Purpose Emerging SARS-CoV-2 variants have impacted the in vitro activity of sotrovimab, with variable fold changes in neutralization potency for the Omicron BA.2 sublineage and onward. The correlation between reduced in vitro activity and clinical efficacy outcomes is unknown. A systematic literatur...

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Veröffentlicht in:	Infection 2024-02, Vol.52 (1), p.1-17
Hauptverfasser:	Drysdale, Myriam, Gibbons, Daniel C., Singh, Moushmi, Rolland, Catherine, Lavoie, Louis, Skingsley, Andrew, Lloyd, Emily J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal, Humanized - therapeutic use Antibodies, Neutralizing Clinical outcomes COVID-19 Effectiveness Family Medicine General Practice Heterogeneity Humans Infectious Diseases Internal Medicine Literature reviews Medicine Medicine & Public Health Monoclonal antibodies Neutralization Patients Population studies Review SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Systematic review
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