Epigenetic HDAC5 Inhibitor Reverses Craniofacial Neuropathic Pain in Mice

Identifying and resolving molecular complexities underlying chronic neuropathic pain is a significant challenge. Among the numerous classes of histone deacetylases, Class I (HDAC 1–3) and Class III (sirtuins) have been best studied in experimental pain models where inhibitor pre-treatments but not p...

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Veröffentlicht in:	The journal of pain 2024-02, Vol.25 (2), p.428-450
Hauptverfasser:	Westlund, Karin N., Montera, Marena, Goins, Aleyah E., Shilling, Mark W., Afaghpour-Becklund, Mitra, Alles, Sascha R.A., Elise Hui, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety Axonal repair genes Axons Benzamides - administration & dosage Chronic pain Epigenesis, Genetic Histone Deacetylase Inhibitors - administration & dosage Histone Deacetylases - metabolism Male Mice Nerve Regeneration Neuralgia - drug therapy Patch-clamp Trigeminal ganglia Trigeminal Ganglion - metabolism
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