Xingbei antitussive granules ameliorate cough hypersensitivity in post-infectious cough guinea pigs by regulating tryptase/PAR2/TRPV1 pathway
Xingbei antitussive granules (XB) is a classic Chinese Medicine prescription for treating post-infectious cough(PIC), based on the Sanao Decoction from Formularies of the Bureau of People’s Welfare Pharmacies in the Song Dynasty and Jiegeng decoction from Essentials of the Golden Chamber in the Han...
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| creator | Li, Yun Zhao, Ruiheng Zhang, Mengyuan Shen, Kunlu Hou, Xin Liu, Bowen Li, Chunxiao Sun, Bingqing Xiang, Min Lin, Jiangtao |
| description | Xingbei antitussive granules (XB) is a classic Chinese Medicine prescription for treating post-infectious cough(PIC), based on the Sanao Decoction from Formularies of the Bureau of People’s Welfare Pharmacies in the Song Dynasty and Jiegeng decoction from Essentials of the Golden Chamber in the Han Dynasty. However, the therapeutic effects and pharmacological mechanisms are still ambiguous. In the present study, we endeavored to elucidate these underlying mechanisms.
This study aimed to explore the potential impact and mechanism of XB on PIC, and provide a scientific basis for its clinical application.
Cigarette smoking (CS) combined with lipopolysaccharide (LPS) nasal drops were administered to induce the PIC guinea pig with cough hypersensitivity status. Subsequently, the model guinea pigs were treated with XB and the cough frequency was observed by the capsaicin cough provocation test. The pathological changes of lung tissue were assessed by HE staining, and the levels of inflammatory mediators, mast cell degranulating substances, and neuropeptides were detected. The protein and mRNA expression of transient receptor potential vanilloid type 1(TRPV1), proteinase-activated receptor2(PAR2), and protein kinase C (PKC) were measured by Immunohistochemical staining, Western blot, and RT-qPCR. Changes in the abundance and composition of respiratory bacterial microbiota were determined by 16S rRNA sequencing.
After XB treatment, the model guinea pigs showed a dose-dependent decrease in cough frequency, along with a significant alleviation in inflammatory infiltration of lung tissue and a reduction in inflammatory mediators. In addition, XB high-dose treatment significantly decreased the levels of mast cell Tryptase as well as β-hexosaminidase (β-Hex) and downregulated the expression of TRPV1, PAR2, and p-PKC. Simultaneously, levels of neuropeptides like substance P (SP), calcitonin gene-related peptide (CGRP), neurokinin A (NKA), and nerve growth factor (NGF) were improved. Besides, XB also can modulate the structure of respiratory bacterial microbiota and restore homeostasis.
XB treatment alleviates cough hypersensitivity and inflammatory responses, inhibits the degranulation of mast cells, and ameliorates neurogenic inflammation in PIC guinea pigs whose mechanism may be associated with the inhibition of Tryptase/PAR2/PKC/TRPV1 and the recovery of respiratory bacterial microbiota.
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•Xingbei Zhike Granules ameliorated cough symptoms and inflamm |
| doi_str_mv | 10.1016/j.jep.2023.117243 |
| format | Article |
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This study aimed to explore the potential impact and mechanism of XB on PIC, and provide a scientific basis for its clinical application.
Cigarette smoking (CS) combined with lipopolysaccharide (LPS) nasal drops were administered to induce the PIC guinea pig with cough hypersensitivity status. Subsequently, the model guinea pigs were treated with XB and the cough frequency was observed by the capsaicin cough provocation test. The pathological changes of lung tissue were assessed by HE staining, and the levels of inflammatory mediators, mast cell degranulating substances, and neuropeptides were detected. The protein and mRNA expression of transient receptor potential vanilloid type 1(TRPV1), proteinase-activated receptor2(PAR2), and protein kinase C (PKC) were measured by Immunohistochemical staining, Western blot, and RT-qPCR. Changes in the abundance and composition of respiratory bacterial microbiota were determined by 16S rRNA sequencing.
After XB treatment, the model guinea pigs showed a dose-dependent decrease in cough frequency, along with a significant alleviation in inflammatory infiltration of lung tissue and a reduction in inflammatory mediators. In addition, XB high-dose treatment significantly decreased the levels of mast cell Tryptase as well as β-hexosaminidase (β-Hex) and downregulated the expression of TRPV1, PAR2, and p-PKC. Simultaneously, levels of neuropeptides like substance P (SP), calcitonin gene-related peptide (CGRP), neurokinin A (NKA), and nerve growth factor (NGF) were improved. Besides, XB also can modulate the structure of respiratory bacterial microbiota and restore homeostasis.
XB treatment alleviates cough hypersensitivity and inflammatory responses, inhibits the degranulation of mast cells, and ameliorates neurogenic inflammation in PIC guinea pigs whose mechanism may be associated with the inhibition of Tryptase/PAR2/PKC/TRPV1 and the recovery of respiratory bacterial microbiota.
[Display omitted]
•Xingbei Zhike Granules ameliorated cough symptoms and inflammatory responses in guinea pigs.•Xingbei Zhike Granules exerted the ameliorative effect on guinea pigs by inhibiting tryptase/PAR2/TRPV1.•Xingbei Zhike Granules down-regulated the expressions of neuroinflammatory mediators in vivo.•Respiratory bacterial microbiota homeostasis may be exploited as a novel therapeutic target for post-infectious cough.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2023.117243</identifier><identifier>PMID: 37777025</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Animals ; Antitussive Agents - pharmacology ; Antitussive Agents - therapeutic use ; Communicable Diseases ; Cough - drug therapy ; Guinea Pigs ; Humans ; Inflammation Mediators ; Neurogenic inflammation ; Post-infectious cough ; Respiratory bacterial microbiota ; RNA, Ribosomal, 16S ; Swine ; TRPV Cation Channels ; TRPV1 ; Tryptases ; Xingbei antitissue granules</subject><ispartof>Journal of ethnopharmacology, 2024-01, Vol.319 (Pt 3), p.117243-117243, Article 117243</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c305t-d94d2e8b16bd14ae974cb05e41d947851091c0f241f09cad1359e9b5149517eb3</cites><orcidid>0000-0003-2013-2556</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2023.117243$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37777025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yun</creatorcontrib><creatorcontrib>Zhao, Ruiheng</creatorcontrib><creatorcontrib>Zhang, Mengyuan</creatorcontrib><creatorcontrib>Shen, Kunlu</creatorcontrib><creatorcontrib>Hou, Xin</creatorcontrib><creatorcontrib>Liu, Bowen</creatorcontrib><creatorcontrib>Li, Chunxiao</creatorcontrib><creatorcontrib>Sun, Bingqing</creatorcontrib><creatorcontrib>Xiang, Min</creatorcontrib><creatorcontrib>Lin, Jiangtao</creatorcontrib><title>Xingbei antitussive granules ameliorate cough hypersensitivity in post-infectious cough guinea pigs by regulating tryptase/PAR2/TRPV1 pathway</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Xingbei antitussive granules (XB) is a classic Chinese Medicine prescription for treating post-infectious cough(PIC), based on the Sanao Decoction from Formularies of the Bureau of People’s Welfare Pharmacies in the Song Dynasty and Jiegeng decoction from Essentials of the Golden Chamber in the Han Dynasty. However, the therapeutic effects and pharmacological mechanisms are still ambiguous. In the present study, we endeavored to elucidate these underlying mechanisms.
This study aimed to explore the potential impact and mechanism of XB on PIC, and provide a scientific basis for its clinical application.
Cigarette smoking (CS) combined with lipopolysaccharide (LPS) nasal drops were administered to induce the PIC guinea pig with cough hypersensitivity status. Subsequently, the model guinea pigs were treated with XB and the cough frequency was observed by the capsaicin cough provocation test. The pathological changes of lung tissue were assessed by HE staining, and the levels of inflammatory mediators, mast cell degranulating substances, and neuropeptides were detected. The protein and mRNA expression of transient receptor potential vanilloid type 1(TRPV1), proteinase-activated receptor2(PAR2), and protein kinase C (PKC) were measured by Immunohistochemical staining, Western blot, and RT-qPCR. Changes in the abundance and composition of respiratory bacterial microbiota were determined by 16S rRNA sequencing.
After XB treatment, the model guinea pigs showed a dose-dependent decrease in cough frequency, along with a significant alleviation in inflammatory infiltration of lung tissue and a reduction in inflammatory mediators. In addition, XB high-dose treatment significantly decreased the levels of mast cell Tryptase as well as β-hexosaminidase (β-Hex) and downregulated the expression of TRPV1, PAR2, and p-PKC. Simultaneously, levels of neuropeptides like substance P (SP), calcitonin gene-related peptide (CGRP), neurokinin A (NKA), and nerve growth factor (NGF) were improved. Besides, XB also can modulate the structure of respiratory bacterial microbiota and restore homeostasis.
XB treatment alleviates cough hypersensitivity and inflammatory responses, inhibits the degranulation of mast cells, and ameliorates neurogenic inflammation in PIC guinea pigs whose mechanism may be associated with the inhibition of Tryptase/PAR2/PKC/TRPV1 and the recovery of respiratory bacterial microbiota.
[Display omitted]
•Xingbei Zhike Granules ameliorated cough symptoms and inflammatory responses in guinea pigs.•Xingbei Zhike Granules exerted the ameliorative effect on guinea pigs by inhibiting tryptase/PAR2/TRPV1.•Xingbei Zhike Granules down-regulated the expressions of neuroinflammatory mediators in vivo.•Respiratory bacterial microbiota homeostasis may be exploited as a novel therapeutic target for post-infectious cough.</description><subject>Animals</subject><subject>Antitussive Agents - pharmacology</subject><subject>Antitussive Agents - therapeutic use</subject><subject>Communicable Diseases</subject><subject>Cough - drug therapy</subject><subject>Guinea Pigs</subject><subject>Humans</subject><subject>Inflammation Mediators</subject><subject>Neurogenic inflammation</subject><subject>Post-infectious cough</subject><subject>Respiratory bacterial microbiota</subject><subject>RNA, Ribosomal, 16S</subject><subject>Swine</subject><subject>TRPV Cation Channels</subject><subject>TRPV1</subject><subject>Tryptases</subject><subject>Xingbei antitissue granules</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1r3DAQhkVpaLZJf0AvRcdevKvxR2TRUwjpBwQaQhJ6E7I89s7ilV1J3uIf0f9chd322LnMYZ55h3dext6DWIOAq81uvcNpnYu8WAPIvCxesRXUMs9kJYvXbCUKWWe1LOGcvQ1hJ4SQUIo37LyQqURerdjvH-T6BokbFynOIdABee-NmwcM3OxxoNGbiNyOc7_l22VCH9AFinSguHByfBpDzMh1aCONcziR_UwODZ-oD7xZuMd-HkxMx3j0yxRNwM399UO-eXy4fwY-mbj9ZZZLdtaZIeC7U79gT59vH2--Znffv3y7ub7LbCGqmLWqbHOsG7hqWigNKlnaRlRYQprIugKhwIouL6ETypoWikqhaiooVQUSm-KCfTzqTn78OWOIek_B4jAYh8mCzmsplKqUgITCEbV-DMFjpydPe-MXDUK_pKB3OqWgX1LQxxTSzoeT_Nzssf238fftCfh0BDCZPBB6HSyhs9iST2_U7Uj_kf8D0uyapA</recordid><startdate>20240130</startdate><enddate>20240130</enddate><creator>Li, Yun</creator><creator>Zhao, Ruiheng</creator><creator>Zhang, Mengyuan</creator><creator>Shen, Kunlu</creator><creator>Hou, Xin</creator><creator>Liu, Bowen</creator><creator>Li, Chunxiao</creator><creator>Sun, Bingqing</creator><creator>Xiang, Min</creator><creator>Lin, Jiangtao</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2013-2556</orcidid></search><sort><creationdate>20240130</creationdate><title>Xingbei antitussive granules ameliorate cough hypersensitivity in post-infectious cough guinea pigs by regulating tryptase/PAR2/TRPV1 pathway</title><author>Li, Yun ; Zhao, Ruiheng ; Zhang, Mengyuan ; Shen, Kunlu ; Hou, Xin ; Liu, Bowen ; Li, Chunxiao ; Sun, Bingqing ; Xiang, Min ; Lin, Jiangtao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-d94d2e8b16bd14ae974cb05e41d947851091c0f241f09cad1359e9b5149517eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Antitussive Agents - pharmacology</topic><topic>Antitussive Agents - therapeutic use</topic><topic>Communicable Diseases</topic><topic>Cough - drug therapy</topic><topic>Guinea Pigs</topic><topic>Humans</topic><topic>Inflammation Mediators</topic><topic>Neurogenic inflammation</topic><topic>Post-infectious cough</topic><topic>Respiratory bacterial microbiota</topic><topic>RNA, Ribosomal, 16S</topic><topic>Swine</topic><topic>TRPV Cation Channels</topic><topic>TRPV1</topic><topic>Tryptases</topic><topic>Xingbei antitissue granules</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yun</creatorcontrib><creatorcontrib>Zhao, Ruiheng</creatorcontrib><creatorcontrib>Zhang, Mengyuan</creatorcontrib><creatorcontrib>Shen, Kunlu</creatorcontrib><creatorcontrib>Hou, Xin</creatorcontrib><creatorcontrib>Liu, Bowen</creatorcontrib><creatorcontrib>Li, Chunxiao</creatorcontrib><creatorcontrib>Sun, Bingqing</creatorcontrib><creatorcontrib>Xiang, Min</creatorcontrib><creatorcontrib>Lin, Jiangtao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yun</au><au>Zhao, Ruiheng</au><au>Zhang, Mengyuan</au><au>Shen, Kunlu</au><au>Hou, Xin</au><au>Liu, Bowen</au><au>Li, Chunxiao</au><au>Sun, Bingqing</au><au>Xiang, Min</au><au>Lin, Jiangtao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Xingbei antitussive granules ameliorate cough hypersensitivity in post-infectious cough guinea pigs by regulating tryptase/PAR2/TRPV1 pathway</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2024-01-30</date><risdate>2024</risdate><volume>319</volume><issue>Pt 3</issue><spage>117243</spage><epage>117243</epage><pages>117243-117243</pages><artnum>117243</artnum><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Xingbei antitussive granules (XB) is a classic Chinese Medicine prescription for treating post-infectious cough(PIC), based on the Sanao Decoction from Formularies of the Bureau of People’s Welfare Pharmacies in the Song Dynasty and Jiegeng decoction from Essentials of the Golden Chamber in the Han Dynasty. However, the therapeutic effects and pharmacological mechanisms are still ambiguous. In the present study, we endeavored to elucidate these underlying mechanisms.
This study aimed to explore the potential impact and mechanism of XB on PIC, and provide a scientific basis for its clinical application.
Cigarette smoking (CS) combined with lipopolysaccharide (LPS) nasal drops were administered to induce the PIC guinea pig with cough hypersensitivity status. Subsequently, the model guinea pigs were treated with XB and the cough frequency was observed by the capsaicin cough provocation test. The pathological changes of lung tissue were assessed by HE staining, and the levels of inflammatory mediators, mast cell degranulating substances, and neuropeptides were detected. The protein and mRNA expression of transient receptor potential vanilloid type 1(TRPV1), proteinase-activated receptor2(PAR2), and protein kinase C (PKC) were measured by Immunohistochemical staining, Western blot, and RT-qPCR. Changes in the abundance and composition of respiratory bacterial microbiota were determined by 16S rRNA sequencing.
After XB treatment, the model guinea pigs showed a dose-dependent decrease in cough frequency, along with a significant alleviation in inflammatory infiltration of lung tissue and a reduction in inflammatory mediators. In addition, XB high-dose treatment significantly decreased the levels of mast cell Tryptase as well as β-hexosaminidase (β-Hex) and downregulated the expression of TRPV1, PAR2, and p-PKC. Simultaneously, levels of neuropeptides like substance P (SP), calcitonin gene-related peptide (CGRP), neurokinin A (NKA), and nerve growth factor (NGF) were improved. Besides, XB also can modulate the structure of respiratory bacterial microbiota and restore homeostasis.
XB treatment alleviates cough hypersensitivity and inflammatory responses, inhibits the degranulation of mast cells, and ameliorates neurogenic inflammation in PIC guinea pigs whose mechanism may be associated with the inhibition of Tryptase/PAR2/PKC/TRPV1 and the recovery of respiratory bacterial microbiota.
[Display omitted]
•Xingbei Zhike Granules ameliorated cough symptoms and inflammatory responses in guinea pigs.•Xingbei Zhike Granules exerted the ameliorative effect on guinea pigs by inhibiting tryptase/PAR2/TRPV1.•Xingbei Zhike Granules down-regulated the expressions of neuroinflammatory mediators in vivo.•Respiratory bacterial microbiota homeostasis may be exploited as a novel therapeutic target for post-infectious cough.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>37777025</pmid><doi>10.1016/j.jep.2023.117243</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-2013-2556</orcidid></addata></record> |
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| ispartof | Journal of ethnopharmacology, 2024-01, Vol.319 (Pt 3), p.117243-117243, Article 117243 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antitussive Agents - pharmacology Antitussive Agents - therapeutic use Communicable Diseases Cough - drug therapy Guinea Pigs Humans Inflammation Mediators Neurogenic inflammation Post-infectious cough Respiratory bacterial microbiota RNA, Ribosomal, 16S Swine TRPV Cation Channels TRPV1 Tryptases Xingbei antitissue granules |
| title | Xingbei antitussive granules ameliorate cough hypersensitivity in post-infectious cough guinea pigs by regulating tryptase/PAR2/TRPV1 pathway |
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