The repeated administration of rhIL‐12 for 14 weeks in rhesus monkeys: A toxicity assessment

Interleukin‐12 (IL‐12) is known to exert antitumor immune effects by promoting the activation and proliferation of T cells and NK cells within the immune system. However, clinical trials have observed systemic toxicity associated with the administration of IL‐12. This has shelved development plans f...

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Veröffentlicht in:	Journal of applied toxicology 2024-02, Vol.44 (2), p.301-312
Hauptverfasser:	Ding, Huiqin, Qin, Huan, Wang, Jiangang, Dong, Yansheng, Wang, Quanjun, Han, Yantao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents Humans IL‐12 Interleukin-12 - toxicity Killer Cells, Natural Macaca mulatta Recombinant Proteins - toxicity repeated administration rhesus monkeys toxicity toxicokinetics
Online-Zugang:	Volltext
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