Spatial mapping of human hematopoiesis at single-cell resolution reveals aging-associated topographic remodeling

•Aging is associated with morphologic changes in hematopoietic stem and progenitor cells and megakaryocytes.•Hematopoietic stem and progenitor cells lie proximal to the bone, vasculature, and megakaryocytes in young BM but further from megakaryocytes in old marrows. [Display omitted] The spatial ana...

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Veröffentlicht in:	Blood 2023-12, Vol.142 (26), p.2282-2295
Hauptverfasser:	Sarachakov, Aleksandr, Varlamova, Arina, Svekolkin, Viktor, Polyakova, Margarita, Valencia, Itzel, Unkenholz, Caitlin, Pannellini, Tania, Galkin, Ilia, Ovcharov, Pavel, Tabakov, Dmitrii, Postovalova, Ekaterina, Shin, Nara, Sethi, Isha, Bagaev, Alexander, Itkin, Tomer, Crane, Genevieve, Kluk, Michael, Geyer, Julia, Inghirami, Giorgio, Patel, Sanjay
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Artificial Intelligence Bone Marrow - pathology Hematopoiesis - physiology Hematopoietic Stem Cells - pathology Humans Mice
Online-Zugang:	Volltext
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