Tumor-suppressive zinc finger protein 24 (ZNF24) sensitizes colorectal cancer cells to 5-fluorouracil by inhibiting the Wnt pathway and activating the p53 signaling

Carcinogenesis and colorectal cancer (CRC) development are associated with dysregulation of various pathways, including Wnt and p53. 5-fluorouracil (5-FU) is a common chemotherapeutic agent for CRC treatment, but its efficacy is restricted by drug resistance. Doxycycline is an orally active tetracyc...

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Veröffentlicht in:	Experimental cell research 2023-12, Vol.433 (1), p.113796, Article 113796
Hauptverfasser:	Meng, Fanqi, Ai, Chunlong, Yan, Guoqiang, Wang, Guangyi
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil resistance Antimetabolites, Antineoplastic - pharmacology Apoptosis - drug effects Cell Line, Tumor Cell Proliferation - drug effects Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Fluorouracil - pharmacology Gene Expression Regulation, Neoplastic - drug effects Humans Inhibitor of Wnt production 2 Kruppel-Like Transcription Factors - genetics p53 signaling Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Wnt pathway Wnt Signaling Pathway - drug effects ZNF24
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