PP2 alleviates the progression of osteoarthritis by inhibiting Wnt/β-catenin and activating TGF-β/Smad signaling

•Our data show the levels of Src, p-Src (y418) and p-FAK in knee cartilage tissue of patients with OA were abnormally increased. After chondrocytes were co-treated with IL-1β and different doses of PP2, the results showed that PP2 could reduce the abnormal increase of β-catenin, p-β-catenin and othe...

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Veröffentlicht in:	International immunopharmacology 2023-11, Vol.124, p.110948-110948, Article 110948
Hauptverfasser:	Zhang, Hao, Zheng, Chuanchuan, Chen, Wei, Li, Xiaoqiang, Wang, Jinshu, Wang, Taikun, Zhao, Qi, Huang, Hao, Li, Yiting, Yang, Chengliang, Xie, Kegong, Pan, Shengcai, Wang, Binghao, Wang, Chong, Tang, Yujin, Li, Kai, Liu, Jia, Wang, Liqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Osteoarthritis PP2 Src TGF-β/Smad signaling Wnt/β-catenin signaling
Online-Zugang:	Volltext
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