Inhibition of KIF11 ameliorates osteoclastogenesis via regulating mTORC1-mediated NF-κB signaling

[Display omitted] Osteoporosis, characterized by over-production and activation of osteoclasts, has become a major health problem especially in elderly women. In our study, we first tested the effect of Caudatin (Cau) in osteoclastogenesis, which is separated from Cynanchum auriculatum as a species...

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Veröffentlicht in:	Biochemical pharmacology 2023-11, Vol.217, p.115817-115817, Article 115817
Hauptverfasser:	Miao, Jiansen, Yao, Hanbing, Liu, Jian, Huang, Zhixian, Shi, Chengge, Lu, Xinyu, Jiang, Junchen, Ren, Rufeng, Wang, Chenyu, Pan, Youjin, Wang, Te, Jin, Haiming
Format:	Artikel
Sprache:	eng
Schlagworte:	Caudatin KIF11 mTORC Osteoclastogenesis Osteoporosis RANKL
Online-Zugang:	Volltext
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