Individual Features of the Hypothalamic—Pituitary—Thyroid Axis Functioning during Aging in Non-Human Primates
Individual features of age-related changes in the function of the neuroendocrine systems are an important problem as the basic component of a personalized approach to predicting and treating age-related pathologies. We studied the age-related features of the function of the hypothalamic—pituitary—th...
Gespeichert in:
| Veröffentlicht in: | Bulletin of experimental biology and medicine 2023-08, Vol.175 (4), p.497-502 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 502 |
|---|---|
| container_issue | 4 |
| container_start_page | 497 |
| container_title | Bulletin of experimental biology and medicine |
| container_volume | 175 |
| creator | Goncharova, N. D. Ermolaeva, A. M. Chigarova, O. A. Oganyan, T. E. Ivanova, L. G. Timoshenko, N. V. |
| description | Individual features of age-related changes in the function of the neuroendocrine systems are an important problem as the basic component of a personalized approach to predicting and treating age-related pathologies. We studied the age-related features of the function of the hypothalamic—pituitary—thyroid axis in laboratory primates with depression- and anxiety-like behavior (DAB). It was found that in young female rhesus monkeys with DAB, the basal and thyrotropin-releasing hormone-stimulated levels of thyroid-stimulating hormone were significantly lower than in young animals with standard behavior (control). During aging, the levels of thyroid-stimulating hormone increased in DAB animals and free thyroxine concentrations decreased both at baseline (fasting) and in response to the thyrotropin-releasing hormone test, while in animals with standard behavior, only a trend towards similar hormonal changes was revealed. |
| doi_str_mv | 10.1007/s10517-023-05894-z |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2870141769</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A776155218</galeid><sourcerecordid>A776155218</sourcerecordid><originalsourceid>FETCH-LOGICAL-c401t-1c9c1bc9226fb3f3e06c0d38eb9dfee58488b90c4d61c42ced121d29bf9d3c3</originalsourceid><addsrcrecordid>eNp9kttqVDEUhjdFwbH6Al4FBPEmNck-Xw7FcQrFFux9yE5WZqfsSaY5SKdXPoRP6JM0uyP0gEggayV8_yJr5S-KD5ScUELaL4GSmraYsBKTuusrfHdULGjdlrhjjL4qFiRTuOq67k3xNoTr-UgauihuzqwyP41KYkIrEDF5CMhpFEdA6_3OxVFMYmvkn1-_L01MJgq_z_nVuPfOKLS8NQGtkpXROGvsBqnk57DczLux6LuzeJ22wqJLb7YiQnhXvNZiCvD-bzwufqy-Xp2u8fnFt7PT5TmWFaERU9lLOsiesUYPpS6BNJKosoOhVxqg7nIzQ09kpRoqKyZBUUYV6wfdq1KWx8XnQ9WddzcJQuRbEyRMk7DgUuCsawmtaNv0Gf34Ar12ydv8tpkqSU8aRh6pjZiAG6td9ELORfmybRta14x2mTr5B5WXgjxEZ0GbfP9M8OmJYAQxxTG4Kc3zDM9BdgCldyF40Hw3D9TvOSV89gA_eIBnD_AHD_C7LCoPorCbvwX8Y2v_Ud0DIp62Nw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2873090620</pqid></control><display><type>article</type><title>Individual Features of the Hypothalamic—Pituitary—Thyroid Axis Functioning during Aging in Non-Human Primates</title><source>Springer Nature - Complete Springer Journals</source><creator>Goncharova, N. D. ; Ermolaeva, A. M. ; Chigarova, O. A. ; Oganyan, T. E. ; Ivanova, L. G. ; Timoshenko, N. V.</creator><creatorcontrib>Goncharova, N. D. ; Ermolaeva, A. M. ; Chigarova, O. A. ; Oganyan, T. E. ; Ivanova, L. G. ; Timoshenko, N. V.</creatorcontrib><description>Individual features of age-related changes in the function of the neuroendocrine systems are an important problem as the basic component of a personalized approach to predicting and treating age-related pathologies. We studied the age-related features of the function of the hypothalamic—pituitary—thyroid axis in laboratory primates with depression- and anxiety-like behavior (DAB). It was found that in young female rhesus monkeys with DAB, the basal and thyrotropin-releasing hormone-stimulated levels of thyroid-stimulating hormone were significantly lower than in young animals with standard behavior (control). During aging, the levels of thyroid-stimulating hormone increased in DAB animals and free thyroxine concentrations decreased both at baseline (fasting) and in response to the thyrotropin-releasing hormone test, while in animals with standard behavior, only a trend towards similar hormonal changes was revealed.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-023-05894-z</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Age ; Aging ; Anxiety ; Biomedical and Life Sciences ; Biomedicine ; Body mass index ; Brain ; Cell Biology ; Depression, Mental ; Ethylenediaminetetraacetic acid ; Females ; Hormones ; Hypothalamus ; Internal Medicine ; Laboratory animals ; Laboratory Medicine ; Medical research ; Medicine, Experimental ; Mental depression ; Metabolism ; Monkeys & apes ; Neuroendocrine system ; Pathology ; Physiology ; Pituitary ; Primatology ; Research centers ; Thyroid ; Thyroid gland ; Thyroid-stimulating hormone ; Thyrotropin ; Thyrotropin-releasing hormone ; Thyroxine ; Type 2 diabetes</subject><ispartof>Bulletin of experimental biology and medicine, 2023-08, Vol.175 (4), p.497-502</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c401t-1c9c1bc9226fb3f3e06c0d38eb9dfee58488b90c4d61c42ced121d29bf9d3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-023-05894-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-023-05894-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Goncharova, N. D.</creatorcontrib><creatorcontrib>Ermolaeva, A. M.</creatorcontrib><creatorcontrib>Chigarova, O. A.</creatorcontrib><creatorcontrib>Oganyan, T. E.</creatorcontrib><creatorcontrib>Ivanova, L. G.</creatorcontrib><creatorcontrib>Timoshenko, N. V.</creatorcontrib><title>Individual Features of the Hypothalamic—Pituitary—Thyroid Axis Functioning during Aging in Non-Human Primates</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><description>Individual features of age-related changes in the function of the neuroendocrine systems are an important problem as the basic component of a personalized approach to predicting and treating age-related pathologies. We studied the age-related features of the function of the hypothalamic—pituitary—thyroid axis in laboratory primates with depression- and anxiety-like behavior (DAB). It was found that in young female rhesus monkeys with DAB, the basal and thyrotropin-releasing hormone-stimulated levels of thyroid-stimulating hormone were significantly lower than in young animals with standard behavior (control). During aging, the levels of thyroid-stimulating hormone increased in DAB animals and free thyroxine concentrations decreased both at baseline (fasting) and in response to the thyrotropin-releasing hormone test, while in animals with standard behavior, only a trend towards similar hormonal changes was revealed.</description><subject>Age</subject><subject>Aging</subject><subject>Anxiety</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body mass index</subject><subject>Brain</subject><subject>Cell Biology</subject><subject>Depression, Mental</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Females</subject><subject>Hormones</subject><subject>Hypothalamus</subject><subject>Internal Medicine</subject><subject>Laboratory animals</subject><subject>Laboratory Medicine</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mental depression</subject><subject>Metabolism</subject><subject>Monkeys & apes</subject><subject>Neuroendocrine system</subject><subject>Pathology</subject><subject>Physiology</subject><subject>Pituitary</subject><subject>Primatology</subject><subject>Research centers</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyrotropin</subject><subject>Thyrotropin-releasing hormone</subject><subject>Thyroxine</subject><subject>Type 2 diabetes</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kttqVDEUhjdFwbH6Al4FBPEmNck-Xw7FcQrFFux9yE5WZqfsSaY5SKdXPoRP6JM0uyP0gEggayV8_yJr5S-KD5ScUELaL4GSmraYsBKTuusrfHdULGjdlrhjjL4qFiRTuOq67k3xNoTr-UgauihuzqwyP41KYkIrEDF5CMhpFEdA6_3OxVFMYmvkn1-_L01MJgq_z_nVuPfOKLS8NQGtkpXROGvsBqnk57DczLux6LuzeJ22wqJLb7YiQnhXvNZiCvD-bzwufqy-Xp2u8fnFt7PT5TmWFaERU9lLOsiesUYPpS6BNJKosoOhVxqg7nIzQ09kpRoqKyZBUUYV6wfdq1KWx8XnQ9WddzcJQuRbEyRMk7DgUuCsawmtaNv0Gf34Ar12ydv8tpkqSU8aRh6pjZiAG6td9ELORfmybRta14x2mTr5B5WXgjxEZ0GbfP9M8OmJYAQxxTG4Kc3zDM9BdgCldyF40Hw3D9TvOSV89gA_eIBnD_AHD_C7LCoPorCbvwX8Y2v_Ud0DIp62Nw</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Goncharova, N. D.</creator><creator>Ermolaeva, A. M.</creator><creator>Chigarova, O. A.</creator><creator>Oganyan, T. E.</creator><creator>Ivanova, L. G.</creator><creator>Timoshenko, N. V.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20230801</creationdate><title>Individual Features of the Hypothalamic—Pituitary—Thyroid Axis Functioning during Aging in Non-Human Primates</title><author>Goncharova, N. D. ; Ermolaeva, A. M. ; Chigarova, O. A. ; Oganyan, T. E. ; Ivanova, L. G. ; Timoshenko, N. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-1c9c1bc9226fb3f3e06c0d38eb9dfee58488b90c4d61c42ced121d29bf9d3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age</topic><topic>Aging</topic><topic>Anxiety</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body mass index</topic><topic>Brain</topic><topic>Cell Biology</topic><topic>Depression, Mental</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Females</topic><topic>Hormones</topic><topic>Hypothalamus</topic><topic>Internal Medicine</topic><topic>Laboratory animals</topic><topic>Laboratory Medicine</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mental depression</topic><topic>Metabolism</topic><topic>Monkeys & apes</topic><topic>Neuroendocrine system</topic><topic>Pathology</topic><topic>Physiology</topic><topic>Pituitary</topic><topic>Primatology</topic><topic>Research centers</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid-stimulating hormone</topic><topic>Thyrotropin</topic><topic>Thyrotropin-releasing hormone</topic><topic>Thyroxine</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goncharova, N. D.</creatorcontrib><creatorcontrib>Ermolaeva, A. M.</creatorcontrib><creatorcontrib>Chigarova, O. A.</creatorcontrib><creatorcontrib>Oganyan, T. E.</creatorcontrib><creatorcontrib>Ivanova, L. G.</creatorcontrib><creatorcontrib>Timoshenko, N. V.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goncharova, N. D.</au><au>Ermolaeva, A. M.</au><au>Chigarova, O. A.</au><au>Oganyan, T. E.</au><au>Ivanova, L. G.</au><au>Timoshenko, N. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Individual Features of the Hypothalamic—Pituitary—Thyroid Axis Functioning during Aging in Non-Human Primates</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><date>2023-08-01</date><risdate>2023</risdate><volume>175</volume><issue>4</issue><spage>497</spage><epage>502</epage><pages>497-502</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>Individual features of age-related changes in the function of the neuroendocrine systems are an important problem as the basic component of a personalized approach to predicting and treating age-related pathologies. We studied the age-related features of the function of the hypothalamic—pituitary—thyroid axis in laboratory primates with depression- and anxiety-like behavior (DAB). It was found that in young female rhesus monkeys with DAB, the basal and thyrotropin-releasing hormone-stimulated levels of thyroid-stimulating hormone were significantly lower than in young animals with standard behavior (control). During aging, the levels of thyroid-stimulating hormone increased in DAB animals and free thyroxine concentrations decreased both at baseline (fasting) and in response to the thyrotropin-releasing hormone test, while in animals with standard behavior, only a trend towards similar hormonal changes was revealed.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10517-023-05894-z</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-4888 |
| ispartof | Bulletin of experimental biology and medicine, 2023-08, Vol.175 (4), p.497-502 |
| issn | 0007-4888 1573-8221 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2870141769 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Age Aging Anxiety Biomedical and Life Sciences Biomedicine Body mass index Brain Cell Biology Depression, Mental Ethylenediaminetetraacetic acid Females Hormones Hypothalamus Internal Medicine Laboratory animals Laboratory Medicine Medical research Medicine, Experimental Mental depression Metabolism Monkeys & apes Neuroendocrine system Pathology Physiology Pituitary Primatology Research centers Thyroid Thyroid gland Thyroid-stimulating hormone Thyrotropin Thyrotropin-releasing hormone Thyroxine Type 2 diabetes |
| title | Individual Features of the Hypothalamic—Pituitary—Thyroid Axis Functioning during Aging in Non-Human Primates |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T16%3A56%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Individual%20Features%20of%20the%20Hypothalamic%E2%80%94Pituitary%E2%80%94Thyroid%20Axis%20Functioning%20during%20Aging%20in%20Non-Human%20Primates&rft.jtitle=Bulletin%20of%20experimental%20biology%20and%20medicine&rft.au=Goncharova,%20N.%20D.&rft.date=2023-08-01&rft.volume=175&rft.issue=4&rft.spage=497&rft.epage=502&rft.pages=497-502&rft.issn=0007-4888&rft.eissn=1573-8221&rft_id=info:doi/10.1007/s10517-023-05894-z&rft_dat=%3Cgale_proqu%3EA776155218%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2873090620&rft_id=info:pmid/&rft_galeid=A776155218&rfr_iscdi=true |