Altered hepatic and intestinal homeostasis in a neonatal murine model of short-term total parenteral nutrition and antibiotics

Parenteral nutrition (PN) prevents starvation and supports metabolic requirements intravenously when patients are unable to be fed enterally. Clinically, infants are frequently provided PN in intensive care settings along with exposure to antibiotics (ABX) to minimize infection during care. Unfortun...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2023-12, Vol.325 (6), p.G556-G569
Hauptverfasser:	Mims, Tahliyah S, Kumari, Roshan, Leathem, Cameron, Antunes, Karen, Joseph, Sydney, Yen, Mei-I, Ferstl, Danielle, Jamieson, Sophia M, Sabbar, Austin, Biebel, Claudia, Lazarevic, Nikolai, Willis, Nathaniel B, Henry, Lydia, Yen, Chi-Liang E, Smith, Joseph P, Gosain, Ankush, Meisel, Marlies, Willis, Kent A, Talati, Ajay J, Elabiad, Mohammad T, Hibl, Brianne, Pierre, Joseph F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animal models Animals Animals, Genetically Modified Anti-Bacterial Agents - pharmacology Antibiotics Cholestasis Disease Models, Animal Drinking water Fatty Liver Female Gallbladder diseases Homeostasis Humans Immune response Infant Infants Inflammation Intestine Leukocytes (neutrophilic) Lipid metabolism Liver Macrophages Metabolism Mice Microbiomes Neonates Parenteral nutrition Parenteral Nutrition, Total Phenotypes Pregnancy Steatosis Swine Transgenic mice Triglycerides
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