Chemotaxis: Dendritic cells as trendsetters of the immune response

Chemotaxis: Dendritic cells as trendsetters of the immune response

A new study reports that dendritic cells actively shape the CCL19 chemokine gradient to which they respond and that the chemokine receptor CCR7 both senses CCL19 and mediates its internalisation. Generation of local changes in chemokines allows coordination of movement over longer distances than pre...

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Veröffentlicht in:Current biology 2023-09, Vol.33 (18), p.R957-R959
Hauptverfasser: Shergold, Amy L., Devlin, Ryan M., Young, Alex L., Roberts, Ed W.
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container_title Current biology
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creator Shergold, Amy L.
Devlin, Ryan M.
Young, Alex L.
Roberts, Ed W.
description A new study reports that dendritic cells actively shape the CCL19 chemokine gradient to which they respond and that the chemokine receptor CCR7 both senses CCL19 and mediates its internalisation. Generation of local changes in chemokines allows coordination of movement over longer distances than previous models could explain. A new study reports that dendritic cells actively shape the CCL19 chemokine gradient to which they respond and that the chemokine receptor CCR7 both senses CCL19 and mediates its internalisation. Generation of local changes in chemokines allows coordination of movement over longer distances than previous models could explain.
doi_str_mv 10.1016/j.cub.2023.08.009
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title Chemotaxis: Dendritic cells as trendsetters of the immune response
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