Clearing and replacing tissue-resident myeloid cells with an anti–CD45-antibody-drug conjugate

•Antibody-drug-conjugates can deplete tissue resident macrophages•Antibody-drug-conjugate conditioning and adoptive cell transfer can alter the disease course of inflammatory conditions Tissue resident myeloid cells (TRM) in adults have highly variable lifespans and may be derived from early embryon...

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Veröffentlicht in:	Blood advances 2023-11, Vol.7 (22), p.6964-6973
Hauptverfasser:	Gustafsson, Karin, Rhee, Catherine, Frodermann, Vanessa, Scadden, Elizabeth W., Li, Dan, Iwamoto, Yoshiko, Palchaudhuri, Rahul, Hyzy, Sharon L., Boitano, Anthony E., Nahrendorf, Matthias, Scadden, David T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bone Marrow Humans Immunoconjugates - pharmacology Macrophages Microglia Monocytes
Online-Zugang:	Volltext
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