Unveiling the role of cerebellar alterations in the autonomic nervous system: a systematic review of autonomic dysfunction in spinocerebellar ataxias
Background Autonomic dysfunctions are prevalent in several cerebellar disorders, but they have not been systematically investigated in spinocerebellar ataxias (SCAs). Studies investigating autonomic deficits in SCAs are fragmented, with each one focusing on different autonomic dysfunctions and diffe...
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| Veröffentlicht in: | Journal of neurology 2023-12, Vol.270 (12), p.5756-5772 |
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| creator | Urbini, Nicole Siciliano, Libera Olivito, Giusy Leggio, Maria |
| description | Background
Autonomic dysfunctions are prevalent in several cerebellar disorders, but they have not been systematically investigated in spinocerebellar ataxias (SCAs). Studies investigating autonomic deficits in SCAs are fragmented, with each one focusing on different autonomic dysfunctions and different SCA subtypes.
Methods
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, we conducted a systematic review of the literature to assess the presence of autonomic dysfunctions in various SCAs. PubMed served as the primary database, and the Rayyan web application was employed for study screening.
Results
We identified 46 articles investigating at least one autonomic function in patients with SCA. The results were analyzed and categorized based on the genetic subtype of SCA, thereby characterizing the specific autonomic deficits associated with each subtype.
Conclusion
This review confirms the presence of autonomic dysfunctions in various genetic subtypes of SCA, underscoring the cerebellum's role in the autonomic nervous system (ANS). It also emphasizes the importance of investigating these functions in clinical practice. |
| doi_str_mv | 10.1007/s00415-023-11993-8 |
| format | Article |
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Autonomic dysfunctions are prevalent in several cerebellar disorders, but they have not been systematically investigated in spinocerebellar ataxias (SCAs). Studies investigating autonomic deficits in SCAs are fragmented, with each one focusing on different autonomic dysfunctions and different SCA subtypes.
Methods
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, we conducted a systematic review of the literature to assess the presence of autonomic dysfunctions in various SCAs. PubMed served as the primary database, and the Rayyan web application was employed for study screening.
Results
We identified 46 articles investigating at least one autonomic function in patients with SCA. The results were analyzed and categorized based on the genetic subtype of SCA, thereby characterizing the specific autonomic deficits associated with each subtype.
Conclusion
This review confirms the presence of autonomic dysfunctions in various genetic subtypes of SCA, underscoring the cerebellum's role in the autonomic nervous system (ANS). It also emphasizes the importance of investigating these functions in clinical practice.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-023-11993-8</identifier><identifier>PMID: 37749264</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Autonomic Nervous System ; Cerebellum ; Dysautonomia ; Humans ; Literature reviews ; Medicine ; Medicine & Public Health ; Nervous system ; Neurology ; Neuroradiology ; Neurosciences ; Primary Dysautonomias ; Review ; Spinocerebellar ataxia ; Spinocerebellar Ataxias - genetics ; Systematic review</subject><ispartof>Journal of neurology, 2023-12, Vol.270 (12), p.5756-5772</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c370t-bb47b4d69a632586a429e0ccadd4675a5eee7adf121bc02daa40fc6664994f833</cites><orcidid>0000-0001-5832-8402 ; 0000-0002-5842-4004 ; 0000-0003-3750-2760 ; 0000-0001-9262-2146</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-023-11993-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-023-11993-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37749264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Urbini, Nicole</creatorcontrib><creatorcontrib>Siciliano, Libera</creatorcontrib><creatorcontrib>Olivito, Giusy</creatorcontrib><creatorcontrib>Leggio, Maria</creatorcontrib><title>Unveiling the role of cerebellar alterations in the autonomic nervous system: a systematic review of autonomic dysfunction in spinocerebellar ataxias</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Background
Autonomic dysfunctions are prevalent in several cerebellar disorders, but they have not been systematically investigated in spinocerebellar ataxias (SCAs). Studies investigating autonomic deficits in SCAs are fragmented, with each one focusing on different autonomic dysfunctions and different SCA subtypes.
Methods
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, we conducted a systematic review of the literature to assess the presence of autonomic dysfunctions in various SCAs. PubMed served as the primary database, and the Rayyan web application was employed for study screening.
Results
We identified 46 articles investigating at least one autonomic function in patients with SCA. The results were analyzed and categorized based on the genetic subtype of SCA, thereby characterizing the specific autonomic deficits associated with each subtype.
Conclusion
This review confirms the presence of autonomic dysfunctions in various genetic subtypes of SCA, underscoring the cerebellum's role in the autonomic nervous system (ANS). It also emphasizes the importance of investigating these functions in clinical practice.</description><subject>Autonomic Nervous System</subject><subject>Cerebellum</subject><subject>Dysautonomia</subject><subject>Humans</subject><subject>Literature reviews</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Primary Dysautonomias</subject><subject>Review</subject><subject>Spinocerebellar ataxia</subject><subject>Spinocerebellar Ataxias - genetics</subject><subject>Systematic review</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kctO3DAUhq2qqAzQF-iistQNm4BvceLuKlQuEhIbZm05zsnUKLGndjJ0HoT3xWGmBXXBypbOd75z7B-hL5ScUUKq80SIoGVBGC8oVYoX9Qe0oIKzgopSfUQLwgUpSl6KQ3SU0gMhpM6FT-iQV5VQTIoFelr6Dbje-RUefwGOoQccOmwhQgN9byI2_QjRjC74hJ1_ocw0Bh8GZ7GHuAlTwmmbRhi-Y7O_Zd7iCBsHj7PutaHdpm7ydtbNtrR2PrwdNpo_zqQTdNCZPsHn_XmMlpc_7y-ui9u7q5uLH7eF5RUZi6YRVSNaqYzkrKylEUwBsda0rZBVaUoAqEzbUUYbS1hrjCCdlVIKpURXc36MTnfedQy_J0ijHlyy8yoe8rM0q6VijAo5o9_-Qx_CFH3eLlN1lX9c0DpTbEfZGFKK0Ol1dIOJW02JnkPTu9B0Dk2_hKbnpq979dQM0P5r-ZtSBvgOSLnkVxBfZ7-jfQbywqYO</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Urbini, Nicole</creator><creator>Siciliano, Libera</creator><creator>Olivito, Giusy</creator><creator>Leggio, Maria</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5832-8402</orcidid><orcidid>https://orcid.org/0000-0002-5842-4004</orcidid><orcidid>https://orcid.org/0000-0003-3750-2760</orcidid><orcidid>https://orcid.org/0000-0001-9262-2146</orcidid></search><sort><creationdate>20231201</creationdate><title>Unveiling the role of cerebellar alterations in the autonomic nervous system: a systematic review of autonomic dysfunction in spinocerebellar ataxias</title><author>Urbini, Nicole ; Siciliano, Libera ; Olivito, Giusy ; Leggio, Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-bb47b4d69a632586a429e0ccadd4675a5eee7adf121bc02daa40fc6664994f833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Autonomic Nervous System</topic><topic>Cerebellum</topic><topic>Dysautonomia</topic><topic>Humans</topic><topic>Literature reviews</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Primary Dysautonomias</topic><topic>Review</topic><topic>Spinocerebellar ataxia</topic><topic>Spinocerebellar Ataxias - genetics</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Urbini, Nicole</creatorcontrib><creatorcontrib>Siciliano, Libera</creatorcontrib><creatorcontrib>Olivito, Giusy</creatorcontrib><creatorcontrib>Leggio, Maria</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Urbini, Nicole</au><au>Siciliano, Libera</au><au>Olivito, Giusy</au><au>Leggio, Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unveiling the role of cerebellar alterations in the autonomic nervous system: a systematic review of autonomic dysfunction in spinocerebellar ataxias</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2023-12-01</date><risdate>2023</risdate><volume>270</volume><issue>12</issue><spage>5756</spage><epage>5772</epage><pages>5756-5772</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><abstract>Background
Autonomic dysfunctions are prevalent in several cerebellar disorders, but they have not been systematically investigated in spinocerebellar ataxias (SCAs). Studies investigating autonomic deficits in SCAs are fragmented, with each one focusing on different autonomic dysfunctions and different SCA subtypes.
Methods
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, we conducted a systematic review of the literature to assess the presence of autonomic dysfunctions in various SCAs. PubMed served as the primary database, and the Rayyan web application was employed for study screening.
Results
We identified 46 articles investigating at least one autonomic function in patients with SCA. The results were analyzed and categorized based on the genetic subtype of SCA, thereby characterizing the specific autonomic deficits associated with each subtype.
Conclusion
This review confirms the presence of autonomic dysfunctions in various genetic subtypes of SCA, underscoring the cerebellum's role in the autonomic nervous system (ANS). It also emphasizes the importance of investigating these functions in clinical practice.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37749264</pmid><doi>10.1007/s00415-023-11993-8</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0001-5832-8402</orcidid><orcidid>https://orcid.org/0000-0002-5842-4004</orcidid><orcidid>https://orcid.org/0000-0003-3750-2760</orcidid><orcidid>https://orcid.org/0000-0001-9262-2146</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Autonomic Nervous System Cerebellum Dysautonomia Humans Literature reviews Medicine Medicine & Public Health Nervous system Neurology Neuroradiology Neurosciences Primary Dysautonomias Review Spinocerebellar ataxia Spinocerebellar Ataxias - genetics Systematic review |
| title | Unveiling the role of cerebellar alterations in the autonomic nervous system: a systematic review of autonomic dysfunction in spinocerebellar ataxias |
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