Smaller Gold Nanoparticles Release DNA More Efficiently During fs Laser Pulsed Optical Heating

This work investigates the effect of plasmonic gold nanoparticle (AuNP) size on the rate of thermal release of single‐stranded oligonucleotides under femtosecond (fs)‐pulsed laser irradiation sources. Contrary to the theoretical predictions that larger AuNPs (50–60 nm diameter) would produce the mos...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-04, Vol.20 (14), p.e2303136-n/a
Hauptverfasser: Hastman, David A., Oh, Eunkeu, Melinger, Joseph S., Green, Christopher M., Thielemann, Aaron J. P., Medintz, Igor L., Díaz, Sebastián A.
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container_issue 14
container_start_page e2303136
container_title Small (Weinheim an der Bergstrasse, Germany)
container_volume 20
creator Hastman, David A.
Oh, Eunkeu
Melinger, Joseph S.
Green, Christopher M.
Thielemann, Aaron J. P.
Medintz, Igor L.
Díaz, Sebastián A.
description This work investigates the effect of plasmonic gold nanoparticle (AuNP) size on the rate of thermal release of single‐stranded oligonucleotides under femtosecond (fs)‐pulsed laser irradiation sources. Contrary to the theoretical predictions that larger AuNPs (50–60 nm diameter) would produce the most solution heating and fastest DNA release, it is found that smaller AuNP diameters (25 nm) lead to faster dsDNA denaturation rates. Controlling for the pulse energy fluence, AuNP concentration, DNA loading density, and the distance from the AuNP surface finds the same result. These results imply that the solution temperature increases around the AuNP during fs laser pulse optical heating may not be the only significant influence on dsDNA denaturation, suggesting that direct energy transfer from the AuNP to the DNA (phonon–phonon coupling), which is increased as AuNPs decrease in size, may play a significant role. Plasmonic gold nanoparticles (AuNP) under femtosecond‐pulsed laser irradiation create short (5 ns) and localized (
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These results imply that the solution temperature increases around the AuNP during fs laser pulse optical heating may not be the only significant influence on dsDNA denaturation, suggesting that direct energy transfer from the AuNP to the DNA (phonon–phonon coupling), which is increased as AuNPs decrease in size, may play a significant role. Plasmonic gold nanoparticles (AuNP) under femtosecond‐pulsed laser irradiation create short (5 ns) and localized (&lt;15 nm) heat gradients that release single‐stranded oligonucleotides through thermal mechanisms. Contrary to the expected results, where larger AuNPs (50–60 nm diameter) would produce the most solution heating and fastest DNA release, smaller AuNP diameters (25 nm) lead to faster dsDNA denaturation rates.</description><identifier>ISSN: 1613-6810</identifier><identifier>EISSN: 1613-6829</identifier><identifier>DOI: 10.1002/smll.202303136</identifier><identifier>PMID: 37749947</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Denaturation ; DNA ; Energy transfer ; Femtosecond pulsed lasers ; Fluence ; fluorescence ; Gold ; heat gradients ; Laser beam heating ; Nanoparticles ; Oligonucleotides ; Phonons ; plasmonics ; pulsed laser ; Pulsed lasers</subject><ispartof>Small (Weinheim an der Bergstrasse, Germany), 2024-04, Vol.20 (14), p.e2303136-n/a</ispartof><rights>2023 Wiley‐VCH GmbH. 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These results imply that the solution temperature increases around the AuNP during fs laser pulse optical heating may not be the only significant influence on dsDNA denaturation, suggesting that direct energy transfer from the AuNP to the DNA (phonon–phonon coupling), which is increased as AuNPs decrease in size, may play a significant role. Plasmonic gold nanoparticles (AuNP) under femtosecond‐pulsed laser irradiation create short (5 ns) and localized (&lt;15 nm) heat gradients that release single‐stranded oligonucleotides through thermal mechanisms. Contrary to the expected results, where larger AuNPs (50–60 nm diameter) would produce the most solution heating and fastest DNA release, smaller AuNP diameters (25 nm) lead to faster dsDNA denaturation rates.</description><subject>Denaturation</subject><subject>DNA</subject><subject>Energy transfer</subject><subject>Femtosecond pulsed lasers</subject><subject>Fluence</subject><subject>fluorescence</subject><subject>Gold</subject><subject>heat gradients</subject><subject>Laser beam heating</subject><subject>Nanoparticles</subject><subject>Oligonucleotides</subject><subject>Phonons</subject><subject>plasmonics</subject><subject>pulsed laser</subject><subject>Pulsed lasers</subject><issn>1613-6810</issn><issn>1613-6829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkMtLw0AQhxdRfFSvHmXBi5fWfSS7yVGsL4hWfFxdppuJRDZJ3W2Q_vduaa3gxdMMzPf7MXyEHHM24oyJ89A4NxJMSCa5VFtknysuhyoT-fZm52yPHITwwSIjEr1L9qTWSZ4nep-8PTfgHHp607mSPkDbzcDPa-sw0Cd0CAHp-OGC3nce6VVV1bbGdu4WdNz7un2nVaBFZDx97F3Akk5mMQyO3iLM4_2Q7FQQD0frOSCv11cvl7fDYnJzd3lRDG2itBpOrWJcZ3mVAeiUJRYUagkSykxOU0i1LXVWpQkXWZKlZVpqm6egpppXHJkFOSBnq96Z7z57DHPT1MGic9Bi1wcjMpULwXSUNCCnf9CPrvdt_M4sJepEpFJFarSirO9C8FiZma8b8AvDmVmaN0vzZmM-Bk7Wtf20wXKD_6iOQL4CvmqHi3_qzPN9UfyWfwN_PI7B</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Hastman, David A.</creator><creator>Oh, Eunkeu</creator><creator>Melinger, Joseph S.</creator><creator>Green, Christopher M.</creator><creator>Thielemann, Aaron J. 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subjects Denaturation
DNA
Energy transfer
Femtosecond pulsed lasers
Fluence
fluorescence
Gold
heat gradients
Laser beam heating
Nanoparticles
Oligonucleotides
Phonons
plasmonics
pulsed laser
Pulsed lasers
title Smaller Gold Nanoparticles Release DNA More Efficiently During fs Laser Pulsed Optical Heating
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