Smaller Gold Nanoparticles Release DNA More Efficiently During fs Laser Pulsed Optical Heating
This work investigates the effect of plasmonic gold nanoparticle (AuNP) size on the rate of thermal release of single‐stranded oligonucleotides under femtosecond (fs)‐pulsed laser irradiation sources. Contrary to the theoretical predictions that larger AuNPs (50–60 nm diameter) would produce the mos...
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creator | Hastman, David A. Oh, Eunkeu Melinger, Joseph S. Green, Christopher M. Thielemann, Aaron J. P. Medintz, Igor L. Díaz, Sebastián A. |
description | This work investigates the effect of plasmonic gold nanoparticle (AuNP) size on the rate of thermal release of single‐stranded oligonucleotides under femtosecond (fs)‐pulsed laser irradiation sources. Contrary to the theoretical predictions that larger AuNPs (50–60 nm diameter) would produce the most solution heating and fastest DNA release, it is found that smaller AuNP diameters (25 nm) lead to faster dsDNA denaturation rates. Controlling for the pulse energy fluence, AuNP concentration, DNA loading density, and the distance from the AuNP surface finds the same result. These results imply that the solution temperature increases around the AuNP during fs laser pulse optical heating may not be the only significant influence on dsDNA denaturation, suggesting that direct energy transfer from the AuNP to the DNA (phonon–phonon coupling), which is increased as AuNPs decrease in size, may play a significant role.
Plasmonic gold nanoparticles (AuNP) under femtosecond‐pulsed laser irradiation create short (5 ns) and localized ( |
doi_str_mv | 10.1002/smll.202303136 |
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Plasmonic gold nanoparticles (AuNP) under femtosecond‐pulsed laser irradiation create short (5 ns) and localized (<15 nm) heat gradients that release single‐stranded oligonucleotides through thermal mechanisms. Contrary to the expected results, where larger AuNPs (50–60 nm diameter) would produce the most solution heating and fastest DNA release, smaller AuNP diameters (25 nm) lead to faster dsDNA denaturation rates.</description><identifier>ISSN: 1613-6810</identifier><identifier>EISSN: 1613-6829</identifier><identifier>DOI: 10.1002/smll.202303136</identifier><identifier>PMID: 37749947</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Denaturation ; DNA ; Energy transfer ; Femtosecond pulsed lasers ; Fluence ; fluorescence ; Gold ; heat gradients ; Laser beam heating ; Nanoparticles ; Oligonucleotides ; Phonons ; plasmonics ; pulsed laser ; Pulsed lasers</subject><ispartof>Small (Weinheim an der Bergstrasse, Germany), 2024-04, Vol.20 (14), p.e2303136-n/a</ispartof><rights>2023 Wiley‐VCH GmbH. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA</rights><rights>2023 Wiley‐VCH GmbH. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.</rights><rights>2024 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4676-bc601789f8aa7504ca6e73a3ad83b5a57cd78f54128485d5d7c95a6b71f1e0ca3</citedby><cites>FETCH-LOGICAL-c4676-bc601789f8aa7504ca6e73a3ad83b5a57cd78f54128485d5d7c95a6b71f1e0ca3</cites><orcidid>0000-0003-1641-522X ; 0000-0002-5568-0512 ; 0000-0002-2452-5245 ; 0000-0002-4972-243X ; 0000-0002-8902-4687 ; 0000-0001-7848-7144</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fsmll.202303136$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fsmll.202303136$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37749947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hastman, David A.</creatorcontrib><creatorcontrib>Oh, Eunkeu</creatorcontrib><creatorcontrib>Melinger, Joseph S.</creatorcontrib><creatorcontrib>Green, Christopher M.</creatorcontrib><creatorcontrib>Thielemann, Aaron J. P.</creatorcontrib><creatorcontrib>Medintz, Igor L.</creatorcontrib><creatorcontrib>Díaz, Sebastián A.</creatorcontrib><title>Smaller Gold Nanoparticles Release DNA More Efficiently During fs Laser Pulsed Optical Heating</title><title>Small (Weinheim an der Bergstrasse, Germany)</title><addtitle>Small</addtitle><description>This work investigates the effect of plasmonic gold nanoparticle (AuNP) size on the rate of thermal release of single‐stranded oligonucleotides under femtosecond (fs)‐pulsed laser irradiation sources. Contrary to the theoretical predictions that larger AuNPs (50–60 nm diameter) would produce the most solution heating and fastest DNA release, it is found that smaller AuNP diameters (25 nm) lead to faster dsDNA denaturation rates. Controlling for the pulse energy fluence, AuNP concentration, DNA loading density, and the distance from the AuNP surface finds the same result. These results imply that the solution temperature increases around the AuNP during fs laser pulse optical heating may not be the only significant influence on dsDNA denaturation, suggesting that direct energy transfer from the AuNP to the DNA (phonon–phonon coupling), which is increased as AuNPs decrease in size, may play a significant role.
Plasmonic gold nanoparticles (AuNP) under femtosecond‐pulsed laser irradiation create short (5 ns) and localized (<15 nm) heat gradients that release single‐stranded oligonucleotides through thermal mechanisms. Contrary to the expected results, where larger AuNPs (50–60 nm diameter) would produce the most solution heating and fastest DNA release, smaller AuNP diameters (25 nm) lead to faster dsDNA denaturation rates.</description><subject>Denaturation</subject><subject>DNA</subject><subject>Energy transfer</subject><subject>Femtosecond pulsed lasers</subject><subject>Fluence</subject><subject>fluorescence</subject><subject>Gold</subject><subject>heat gradients</subject><subject>Laser beam heating</subject><subject>Nanoparticles</subject><subject>Oligonucleotides</subject><subject>Phonons</subject><subject>plasmonics</subject><subject>pulsed laser</subject><subject>Pulsed lasers</subject><issn>1613-6810</issn><issn>1613-6829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkMtLw0AQhxdRfFSvHmXBi5fWfSS7yVGsL4hWfFxdppuJRDZJ3W2Q_vduaa3gxdMMzPf7MXyEHHM24oyJ89A4NxJMSCa5VFtknysuhyoT-fZm52yPHITwwSIjEr1L9qTWSZ4nep-8PTfgHHp607mSPkDbzcDPa-sw0Cd0CAHp-OGC3nce6VVV1bbGdu4WdNz7un2nVaBFZDx97F3Akk5mMQyO3iLM4_2Q7FQQD0frOSCv11cvl7fDYnJzd3lRDG2itBpOrWJcZ3mVAeiUJRYUagkSykxOU0i1LXVWpQkXWZKlZVpqm6egpppXHJkFOSBnq96Z7z57DHPT1MGic9Bi1wcjMpULwXSUNCCnf9CPrvdt_M4sJepEpFJFarSirO9C8FiZma8b8AvDmVmaN0vzZmM-Bk7Wtf20wXKD_6iOQL4CvmqHi3_qzPN9UfyWfwN_PI7B</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Hastman, David A.</creator><creator>Oh, Eunkeu</creator><creator>Melinger, Joseph S.</creator><creator>Green, Christopher M.</creator><creator>Thielemann, Aaron J. P.</creator><creator>Medintz, Igor L.</creator><creator>Díaz, Sebastián A.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1641-522X</orcidid><orcidid>https://orcid.org/0000-0002-5568-0512</orcidid><orcidid>https://orcid.org/0000-0002-2452-5245</orcidid><orcidid>https://orcid.org/0000-0002-4972-243X</orcidid><orcidid>https://orcid.org/0000-0002-8902-4687</orcidid><orcidid>https://orcid.org/0000-0001-7848-7144</orcidid></search><sort><creationdate>20240401</creationdate><title>Smaller Gold Nanoparticles Release DNA More Efficiently During fs Laser Pulsed Optical Heating</title><author>Hastman, David A. ; Oh, Eunkeu ; Melinger, Joseph S. ; Green, Christopher M. ; Thielemann, Aaron J. P. ; Medintz, Igor L. ; Díaz, Sebastián A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4676-bc601789f8aa7504ca6e73a3ad83b5a57cd78f54128485d5d7c95a6b71f1e0ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Denaturation</topic><topic>DNA</topic><topic>Energy transfer</topic><topic>Femtosecond pulsed lasers</topic><topic>Fluence</topic><topic>fluorescence</topic><topic>Gold</topic><topic>heat gradients</topic><topic>Laser beam heating</topic><topic>Nanoparticles</topic><topic>Oligonucleotides</topic><topic>Phonons</topic><topic>plasmonics</topic><topic>pulsed laser</topic><topic>Pulsed lasers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hastman, David A.</creatorcontrib><creatorcontrib>Oh, Eunkeu</creatorcontrib><creatorcontrib>Melinger, Joseph S.</creatorcontrib><creatorcontrib>Green, Christopher M.</creatorcontrib><creatorcontrib>Thielemann, Aaron J. P.</creatorcontrib><creatorcontrib>Medintz, Igor L.</creatorcontrib><creatorcontrib>Díaz, Sebastián A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Small (Weinheim an der Bergstrasse, Germany)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hastman, David A.</au><au>Oh, Eunkeu</au><au>Melinger, Joseph S.</au><au>Green, Christopher M.</au><au>Thielemann, Aaron J. P.</au><au>Medintz, Igor L.</au><au>Díaz, Sebastián A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Smaller Gold Nanoparticles Release DNA More Efficiently During fs Laser Pulsed Optical Heating</atitle><jtitle>Small (Weinheim an der Bergstrasse, Germany)</jtitle><addtitle>Small</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>20</volume><issue>14</issue><spage>e2303136</spage><epage>n/a</epage><pages>e2303136-n/a</pages><issn>1613-6810</issn><eissn>1613-6829</eissn><abstract>This work investigates the effect of plasmonic gold nanoparticle (AuNP) size on the rate of thermal release of single‐stranded oligonucleotides under femtosecond (fs)‐pulsed laser irradiation sources. Contrary to the theoretical predictions that larger AuNPs (50–60 nm diameter) would produce the most solution heating and fastest DNA release, it is found that smaller AuNP diameters (25 nm) lead to faster dsDNA denaturation rates. Controlling for the pulse energy fluence, AuNP concentration, DNA loading density, and the distance from the AuNP surface finds the same result. These results imply that the solution temperature increases around the AuNP during fs laser pulse optical heating may not be the only significant influence on dsDNA denaturation, suggesting that direct energy transfer from the AuNP to the DNA (phonon–phonon coupling), which is increased as AuNPs decrease in size, may play a significant role.
Plasmonic gold nanoparticles (AuNP) under femtosecond‐pulsed laser irradiation create short (5 ns) and localized (<15 nm) heat gradients that release single‐stranded oligonucleotides through thermal mechanisms. Contrary to the expected results, where larger AuNPs (50–60 nm diameter) would produce the most solution heating and fastest DNA release, smaller AuNP diameters (25 nm) lead to faster dsDNA denaturation rates.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37749947</pmid><doi>10.1002/smll.202303136</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1641-522X</orcidid><orcidid>https://orcid.org/0000-0002-5568-0512</orcidid><orcidid>https://orcid.org/0000-0002-2452-5245</orcidid><orcidid>https://orcid.org/0000-0002-4972-243X</orcidid><orcidid>https://orcid.org/0000-0002-8902-4687</orcidid><orcidid>https://orcid.org/0000-0001-7848-7144</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Denaturation DNA Energy transfer Femtosecond pulsed lasers Fluence fluorescence Gold heat gradients Laser beam heating Nanoparticles Oligonucleotides Phonons plasmonics pulsed laser Pulsed lasers |
title | Smaller Gold Nanoparticles Release DNA More Efficiently During fs Laser Pulsed Optical Heating |
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