PRICKLE1 gene methylation and abnormal transcription in Chinese patients with ankylosing spondylitis

•Dysmethylation of PRICKLE1 promoter up-regulated mRNA expression in AS.•The methylation of PRICKLE1 gene promoter was observed to be correlated with inflammation and disease severity in AS.•Treatment may affect the methylation status of gene promoters. Ankylosing spondylitis (AS) is a common inflam...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Immunobiology (1979) 2023-11, Vol.228 (6), p.152742-152742, Article 152742
Hauptverfasser:	Zhou, Tingting, Wang, Xinqi, Kong, Jiangping, Yu, Lingxiang, Xie, Huimin, Wang, Feier, Xu, Shenqian, Shuai, Zongwen, Zhou, Qiang, Pan, Faming
Format:	Artikel
Sprache:	eng
Schlagworte:	Ankylosing spondylitis Biomarkers - metabolism China DNA Methylation Epigenetic inheritance Humans LIM Domain Proteins - genetics LIM Domain Proteins - metabolism mRNA PRICKLE1 gene RNA, Messenger - genetics RNA, Messenger - metabolism Spondylitis, Ankylosing - genetics Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!