A Mechanistic Physiologically‐Based Pharmacokinetic Platform Model to Guide Adult and Pediatric Intravenous and Subcutaneous Dosing for Bispecific T Cell Engagers
Bispecific T cell engagers (Bi‐TCEs) have revolutionized the treatment of oncology indications across both liquid and solid tumors. Bi‐TCEs are rapidly evolving from conventional intravenous (i.v.) to more convenient subcutaneous (s.c.) administrations and extending beyond adults to also benefit ped...
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| Veröffentlicht in: | Clinical pharmacology and therapeutics 2024-03, Vol.115 (3), p.457-467 |
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| creator | Zhang, Xinwen Lumen, Annie Wong, Hansen Connarn, Jamie Dutta, Sandeep Upreti, Vijay V. |
| description | Bispecific T cell engagers (Bi‐TCEs) have revolutionized the treatment of oncology indications across both liquid and solid tumors. Bi‐TCEs are rapidly evolving from conventional intravenous (i.v.) to more convenient subcutaneous (s.c.) administrations and extending beyond adults to also benefit pediatric patients. Leveraging clinical development experience across three generations of Bi‐TCE molecules across both liquid and solid tumor indications from i.v./s.c. dosing in adults and pediatric subjects, we developed a mechanistic‐physiologically‐based pharmacokinetic (PBPK) platform model for Bi‐TCEs. The model utilizes a full PBPK model framework and was successfully validated for PK predictions following i.v. and s.c. dosing across both liquid and solid tumor space in adults for eight Bi‐TCEs. After refinement to incorporate physiological ontogeny, the model was successfully validated to predict pediatric PKs in 1 month – |
| doi_str_mv | 10.1002/cpt.3056 |
| format | Article |
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Bi‐TCEs are rapidly evolving from conventional intravenous (i.v.) to more convenient subcutaneous (s.c.) administrations and extending beyond adults to also benefit pediatric patients. Leveraging clinical development experience across three generations of Bi‐TCE molecules across both liquid and solid tumor indications from i.v./s.c. dosing in adults and pediatric subjects, we developed a mechanistic‐physiologically‐based pharmacokinetic (PBPK) platform model for Bi‐TCEs. The model utilizes a full PBPK model framework and was successfully validated for PK predictions following i.v. and s.c. dosing across both liquid and solid tumor space in adults for eight Bi‐TCEs. After refinement to incorporate physiological ontogeny, the model was successfully validated to predict pediatric PKs in 1 month – < 2 years, 2–11 years, and 12–17 years old subjects following i.v. dosing. Following s.c. dosing in pediatric subjects, the model predicted similar bioavailability, however, a shorter time to maximum concentration (Tmax) for the three age groups compared with adults. The model was also applied to guide the dosing strategy for first generation of Bi‐TCEs for organ impairment, specifically renal impairment, and was able to accurately predict the impact of renal impairment on PK for these relatively small‐size Bi‐TCEs. This work highlights a novel mechanistic platform model for accurately predicting the PK in adult and pediatric patients across liquid and solid tumor indications from i.v./s.c. dosing and can be used to guide optimal dose and dosing regimen selection and accelerating the clinical development for Bi‐TCEs.</description><identifier>ISSN: 0009-9236</identifier><identifier>EISSN: 1532-6535</identifier><identifier>DOI: 10.1002/cpt.3056</identifier><identifier>PMID: 37746860</identifier><language>eng</language><publisher>United States</publisher><ispartof>Clinical pharmacology and therapeutics, 2024-03, Vol.115 (3), p.457-467</ispartof><rights>2023 Amgen Inc. © 2023 American Society for Clinical Pharmacology and Therapeutics.</rights><rights>2023 Amgen Inc. 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Following s.c. dosing in pediatric subjects, the model predicted similar bioavailability, however, a shorter time to maximum concentration (Tmax) for the three age groups compared with adults. The model was also applied to guide the dosing strategy for first generation of Bi‐TCEs for organ impairment, specifically renal impairment, and was able to accurately predict the impact of renal impairment on PK for these relatively small‐size Bi‐TCEs. 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Following s.c. dosing in pediatric subjects, the model predicted similar bioavailability, however, a shorter time to maximum concentration (Tmax) for the three age groups compared with adults. The model was also applied to guide the dosing strategy for first generation of Bi‐TCEs for organ impairment, specifically renal impairment, and was able to accurately predict the impact of renal impairment on PK for these relatively small‐size Bi‐TCEs. This work highlights a novel mechanistic platform model for accurately predicting the PK in adult and pediatric patients across liquid and solid tumor indications from i.v./s.c. dosing and can be used to guide optimal dose and dosing regimen selection and accelerating the clinical development for Bi‐TCEs.</abstract><cop>United States</cop><pmid>37746860</pmid><doi>10.1002/cpt.3056</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-1018-7166</orcidid><oa>free_for_read</oa></addata></record> |
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| title | A Mechanistic Physiologically‐Based Pharmacokinetic Platform Model to Guide Adult and Pediatric Intravenous and Subcutaneous Dosing for Bispecific T Cell Engagers |
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