Clinical characteristics and prognosis of patients with heart failure and high concentrations of interleukin-17D
Heart failure (HF) is associated with cytokine activation and inflammation. Experimental evidence suggests that plasma interleukin-17 (IL-17) is associated with myocardial fibrosis and cardiac dysfunction in HF. IL-17D, a subtype of IL-17 originates from particular tissues such as the heart. However...
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| Veröffentlicht in: | International journal of cardiology 2024-02, Vol.396, p.131384-131384, Article 131384 |
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| container_title | International journal of cardiology |
| container_volume | 396 |
| creator | Baumhove, Lukas Bomer, Nils Tromp, Jasper van Essen, Bart J. Dickstein, Kenneth Cleland, John G. Lang, Chim C. Ng, Leong L. Samani, Nilesh J. Anker, Stefan D. Metra, Marco van Veldhuisen, Dirk J. van der Meer, Peter Voors, Adriaan A. |
| description | Heart failure (HF) is associated with cytokine activation and inflammation. Experimental evidence suggests that plasma interleukin-17 (IL-17) is associated with myocardial fibrosis and cardiac dysfunction in HF. IL-17D, a subtype of IL-17 originates from particular tissues such as the heart. However, there is very limited data on the IL-17 cytokine family in patients with HF. Therefore, we investigated the association between circulating IL-17D levels, clinical characteristics and outcome in a large cohort of patients with heart failure.
Plasma IL-17D was measured in 2032 patients with HF from 11 European countries using a proximity extension assay. The primary outcome was a composite of HF hospitalization or all-cause mortality. Patients with higher plasma IL-17D concentrations were more likely to have atrial fibrillation (AF), renal dysfunction and heart failure with preserved ejection fraction (HFpEF) and had higher plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations (all p |
| doi_str_mv | 10.1016/j.ijcard.2023.131384 |
| format | Article |
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Plasma IL-17D was measured in 2032 patients with HF from 11 European countries using a proximity extension assay. The primary outcome was a composite of HF hospitalization or all-cause mortality. Patients with higher plasma IL-17D concentrations were more likely to have atrial fibrillation (AF), renal dysfunction and heart failure with preserved ejection fraction (HFpEF) and had higher plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations (all p < 0.001). IL-17D was not associated with interleukin-6 (IL-6) or C-reactive protein (CRP) concentrations. After adjustment for confounders in a multivariable Cox regression analysis, patients in the highest quartile of plasma IL-17D had a significantly increased risk of the composite outcome of HF hospitalization or all-cause mortality compared to patients in the lowest quartile [Hazard ratio (HR) 1.28, 95% confidence interval (CI) 1.05–1.57].
In patients with HF, elevated plasma IL-17D concentrations are associated with higher plasma NT-proBNP concentrations and a higher prevalence of AF and renal dysfunction. High IL-17D concentrations are independently associated with worse outcome.
•Patients with heart failure (HF) and high IL-17D concentrations are more likely to have atrial fibrillation and renal dysfunction•In patients with HF, elevated plasma IL-17D concentrations are associated with higher plasma NT-proBNP concentrations.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2023.131384</identifier><identifier>PMID: 37739044</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Biomarkers ; Cytokines ; Heart Failure ; Humans ; Inflammation ; Interleukin-17 ; Interleukin-27 ; Kidney Diseases ; Natriuretic Peptide, Brain ; Peptide Fragments ; Prognosis ; Stroke Volume - physiology</subject><ispartof>International journal of cardiology, 2024-02, Vol.396, p.131384-131384, Article 131384</ispartof><rights>2023 The Author(s)</rights><rights>Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-9e80b1240bbd59bb80607e8a35aeecd47b3694b1f9e8ad9bb0df8639d978fbfd3</citedby><cites>FETCH-LOGICAL-c408t-9e80b1240bbd59bb80607e8a35aeecd47b3694b1f9e8ad9bb0df8639d978fbfd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37739044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baumhove, Lukas</creatorcontrib><creatorcontrib>Bomer, Nils</creatorcontrib><creatorcontrib>Tromp, Jasper</creatorcontrib><creatorcontrib>van Essen, Bart J.</creatorcontrib><creatorcontrib>Dickstein, Kenneth</creatorcontrib><creatorcontrib>Cleland, John G.</creatorcontrib><creatorcontrib>Lang, Chim C.</creatorcontrib><creatorcontrib>Ng, Leong L.</creatorcontrib><creatorcontrib>Samani, Nilesh J.</creatorcontrib><creatorcontrib>Anker, Stefan D.</creatorcontrib><creatorcontrib>Metra, Marco</creatorcontrib><creatorcontrib>van Veldhuisen, Dirk J.</creatorcontrib><creatorcontrib>van der Meer, Peter</creatorcontrib><creatorcontrib>Voors, Adriaan A.</creatorcontrib><title>Clinical characteristics and prognosis of patients with heart failure and high concentrations of interleukin-17D</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Heart failure (HF) is associated with cytokine activation and inflammation. Experimental evidence suggests that plasma interleukin-17 (IL-17) is associated with myocardial fibrosis and cardiac dysfunction in HF. IL-17D, a subtype of IL-17 originates from particular tissues such as the heart. However, there is very limited data on the IL-17 cytokine family in patients with HF. Therefore, we investigated the association between circulating IL-17D levels, clinical characteristics and outcome in a large cohort of patients with heart failure.
Plasma IL-17D was measured in 2032 patients with HF from 11 European countries using a proximity extension assay. The primary outcome was a composite of HF hospitalization or all-cause mortality. Patients with higher plasma IL-17D concentrations were more likely to have atrial fibrillation (AF), renal dysfunction and heart failure with preserved ejection fraction (HFpEF) and had higher plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations (all p < 0.001). IL-17D was not associated with interleukin-6 (IL-6) or C-reactive protein (CRP) concentrations. After adjustment for confounders in a multivariable Cox regression analysis, patients in the highest quartile of plasma IL-17D had a significantly increased risk of the composite outcome of HF hospitalization or all-cause mortality compared to patients in the lowest quartile [Hazard ratio (HR) 1.28, 95% confidence interval (CI) 1.05–1.57].
In patients with HF, elevated plasma IL-17D concentrations are associated with higher plasma NT-proBNP concentrations and a higher prevalence of AF and renal dysfunction. High IL-17D concentrations are independently associated with worse outcome.
•Patients with heart failure (HF) and high IL-17D concentrations are more likely to have atrial fibrillation and renal dysfunction•In patients with HF, elevated plasma IL-17D concentrations are associated with higher plasma NT-proBNP concentrations.</description><subject>Biomarkers</subject><subject>Cytokines</subject><subject>Heart Failure</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin-17</subject><subject>Interleukin-27</subject><subject>Kidney Diseases</subject><subject>Natriuretic Peptide, Brain</subject><subject>Peptide Fragments</subject><subject>Prognosis</subject><subject>Stroke Volume - physiology</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EotvCP0DIRy5Z7NiJnQsS2gJFqsQFzpY_Js0sWWexHRD_HrcpHDnN5XnfmXkIecXZnjPevz3u8ehtCvuWtWLPBRdaPiE7rpVsuOrkU7KrmGq6VokLcpnzkTEmh0E_JxdCKTEwKXfkfJgxorcz9ZNN1hdImAv6TG0M9JyWu7hkzHQZ6dkWhFgy_YVlohPYVOhocV4TPMAT3k3UL9FXKFV2iQ8xjLVzhvU7xnrX9QvybLRzhpeP84p8-_jh6-Gmuf3y6fPh_W3jJdOlGUAzx1vJnAvd4JxmPVOgregsgA9SOdEP0vGxgjZUgIVR92IIg9KjG4O4Im-23vrDjxVyMSfMHubZRljWbFrda97qtu8qKjfUpyXnBKM5JzzZ9NtwZu5dm6PZXJt712ZzXWOvHzes7gThX-iv3Aq82wCof_5ESCb7atBDwAS-mLDg_zf8ARW-lBw</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Baumhove, Lukas</creator><creator>Bomer, Nils</creator><creator>Tromp, Jasper</creator><creator>van Essen, Bart J.</creator><creator>Dickstein, Kenneth</creator><creator>Cleland, John G.</creator><creator>Lang, Chim C.</creator><creator>Ng, Leong L.</creator><creator>Samani, Nilesh J.</creator><creator>Anker, Stefan D.</creator><creator>Metra, Marco</creator><creator>van Veldhuisen, Dirk J.</creator><creator>van der Meer, Peter</creator><creator>Voors, Adriaan A.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240201</creationdate><title>Clinical characteristics and prognosis of patients with heart failure and high concentrations of interleukin-17D</title><author>Baumhove, Lukas ; Bomer, Nils ; Tromp, Jasper ; van Essen, Bart J. ; Dickstein, Kenneth ; Cleland, John G. ; Lang, Chim C. ; Ng, Leong L. ; Samani, Nilesh J. ; Anker, Stefan D. ; Metra, Marco ; van Veldhuisen, Dirk J. ; van der Meer, Peter ; Voors, Adriaan A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-9e80b1240bbd59bb80607e8a35aeecd47b3694b1f9e8ad9bb0df8639d978fbfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biomarkers</topic><topic>Cytokines</topic><topic>Heart Failure</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin-17</topic><topic>Interleukin-27</topic><topic>Kidney Diseases</topic><topic>Natriuretic Peptide, Brain</topic><topic>Peptide Fragments</topic><topic>Prognosis</topic><topic>Stroke Volume - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baumhove, Lukas</creatorcontrib><creatorcontrib>Bomer, Nils</creatorcontrib><creatorcontrib>Tromp, Jasper</creatorcontrib><creatorcontrib>van Essen, Bart J.</creatorcontrib><creatorcontrib>Dickstein, Kenneth</creatorcontrib><creatorcontrib>Cleland, John G.</creatorcontrib><creatorcontrib>Lang, Chim C.</creatorcontrib><creatorcontrib>Ng, Leong L.</creatorcontrib><creatorcontrib>Samani, Nilesh J.</creatorcontrib><creatorcontrib>Anker, Stefan D.</creatorcontrib><creatorcontrib>Metra, Marco</creatorcontrib><creatorcontrib>van Veldhuisen, Dirk J.</creatorcontrib><creatorcontrib>van der Meer, Peter</creatorcontrib><creatorcontrib>Voors, Adriaan A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baumhove, Lukas</au><au>Bomer, Nils</au><au>Tromp, Jasper</au><au>van Essen, Bart J.</au><au>Dickstein, Kenneth</au><au>Cleland, John G.</au><au>Lang, Chim C.</au><au>Ng, Leong L.</au><au>Samani, Nilesh J.</au><au>Anker, Stefan D.</au><au>Metra, Marco</au><au>van Veldhuisen, Dirk J.</au><au>van der Meer, Peter</au><au>Voors, Adriaan A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characteristics and prognosis of patients with heart failure and high concentrations of interleukin-17D</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>396</volume><spage>131384</spage><epage>131384</epage><pages>131384-131384</pages><artnum>131384</artnum><issn>0167-5273</issn><eissn>1874-1754</eissn><abstract>Heart failure (HF) is associated with cytokine activation and inflammation. Experimental evidence suggests that plasma interleukin-17 (IL-17) is associated with myocardial fibrosis and cardiac dysfunction in HF. IL-17D, a subtype of IL-17 originates from particular tissues such as the heart. However, there is very limited data on the IL-17 cytokine family in patients with HF. Therefore, we investigated the association between circulating IL-17D levels, clinical characteristics and outcome in a large cohort of patients with heart failure.
Plasma IL-17D was measured in 2032 patients with HF from 11 European countries using a proximity extension assay. The primary outcome was a composite of HF hospitalization or all-cause mortality. Patients with higher plasma IL-17D concentrations were more likely to have atrial fibrillation (AF), renal dysfunction and heart failure with preserved ejection fraction (HFpEF) and had higher plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations (all p < 0.001). IL-17D was not associated with interleukin-6 (IL-6) or C-reactive protein (CRP) concentrations. After adjustment for confounders in a multivariable Cox regression analysis, patients in the highest quartile of plasma IL-17D had a significantly increased risk of the composite outcome of HF hospitalization or all-cause mortality compared to patients in the lowest quartile [Hazard ratio (HR) 1.28, 95% confidence interval (CI) 1.05–1.57].
In patients with HF, elevated plasma IL-17D concentrations are associated with higher plasma NT-proBNP concentrations and a higher prevalence of AF and renal dysfunction. High IL-17D concentrations are independently associated with worse outcome.
•Patients with heart failure (HF) and high IL-17D concentrations are more likely to have atrial fibrillation and renal dysfunction•In patients with HF, elevated plasma IL-17D concentrations are associated with higher plasma NT-proBNP concentrations.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>37739044</pmid><doi>10.1016/j.ijcard.2023.131384</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers Cytokines Heart Failure Humans Inflammation Interleukin-17 Interleukin-27 Kidney Diseases Natriuretic Peptide, Brain Peptide Fragments Prognosis Stroke Volume - physiology |
| title | Clinical characteristics and prognosis of patients with heart failure and high concentrations of interleukin-17D |
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