Intra-articular injection of tranexamic acid in patients with haemophilia arthritis: retrospective controlled study in total knee arthroplasty
Purpose Total knee arthroplasty is the main method for the treatment of advanced haemophilic knee arthritis. Due to the particularity of hemophilia, the blood management plan is the focus of the perioperative period for haemophilia patients. This study aimed to investigate the clinical effect and sa...
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| Veröffentlicht in: | International orthopaedics 2024-03, Vol.48 (3), p.683-692 |
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| creator | Xiang, Si-cheng Shen, Shao-ning Wang, Rui Wang, Zheng-ming Jin, Zhao-kai Su, Hai Tong, Pei-jian Lv, Shuai-jie |
| description | Purpose
Total knee arthroplasty is the main method for the treatment of advanced haemophilic knee arthritis. Due to the particularity of hemophilia, the blood management plan is the focus of the perioperative period for haemophilia patients. This study aimed to investigate the clinical effect and safety of intra-articular injection of tranexamic acid in patients with haemophilia.
Methods
This is a retrospective study. According to whether tranexamic acid is used or not, patients are divided into tranexamic acid group (
n
=30) and non-tranexamic acid group (
n
=29). Total blood loss, intraoperative blood loss, complete blood count, total amount of coagulation factor VIII (FVIII) usage, coagulation biomarkers, inflammatory biomarkers, knee range of motion, knee joint function, pain status, complication rate, and patient satisfaction were assessed and compared at a mean follow-up of 16 months.
Results
Injecting tranexamic acid into the knee joint cavity can effectively reduce the hidden blood loss and total blood loss (
P |
| doi_str_mv | 10.1007/s00264-023-05983-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2868124581</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2868124581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-df723dfccb9f5f5d43269e2655e6319cce6284dd6f7bb5efef9aea81134f7f8a3</originalsourceid><addsrcrecordid>eNp9kc2OFCEUhYnROD2jL-DCsHTDyE9RRbkzk1EnmcSNrgkNF5uWKkqg1H4Jn1naGl264ib3nI-cexB6weg1o3R4XSjlfUcoF4TKUQmiHqEd6wQnko3yMdpR0THC-1FeoMtSjpSyoVfsKboQw9DRNu_Qr7u5ZkNMrsGu0WQc5iPYGtKMk8dtNcNPMwWLjQ2uLfFiaoC5Fvwj1AM-GJjScggxGNwYhxxqKG9whppTWc6g74Btan-kGMHhUld3OmNqqibirzPA5ktLNKWenqEn3sQCzx_eK_T53e2nmw_k_uP7u5u398SKbqjE-YEL563dj1566VrmfgTeSwm9YKO10HPVOdf7Yb-X4MGPBoxiTHR-8MqIK_Rq4y45fVuhVD2FYiHGljetRXPVDsU7qViT8k1qW6SSweslh8nkk2ZUn3vQWw-69aD_9KBVM7184K_7Cdw_y9_DN4HYBKWt5i-Q9TGteW6Z_4f9DQmImMQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2868124581</pqid></control><display><type>article</type><title>Intra-articular injection of tranexamic acid in patients with haemophilia arthritis: retrospective controlled study in total knee arthroplasty</title><source>SpringerLink_现刊</source><creator>Xiang, Si-cheng ; Shen, Shao-ning ; Wang, Rui ; Wang, Zheng-ming ; Jin, Zhao-kai ; Su, Hai ; Tong, Pei-jian ; Lv, Shuai-jie</creator><creatorcontrib>Xiang, Si-cheng ; Shen, Shao-ning ; Wang, Rui ; Wang, Zheng-ming ; Jin, Zhao-kai ; Su, Hai ; Tong, Pei-jian ; Lv, Shuai-jie</creatorcontrib><description>Purpose
Total knee arthroplasty is the main method for the treatment of advanced haemophilic knee arthritis. Due to the particularity of hemophilia, the blood management plan is the focus of the perioperative period for haemophilia patients. This study aimed to investigate the clinical effect and safety of intra-articular injection of tranexamic acid in patients with haemophilia.
Methods
This is a retrospective study. According to whether tranexamic acid is used or not, patients are divided into tranexamic acid group (
n
=30) and non-tranexamic acid group (
n
=29). Total blood loss, intraoperative blood loss, complete blood count, total amount of coagulation factor VIII (FVIII) usage, coagulation biomarkers, inflammatory biomarkers, knee range of motion, knee joint function, pain status, complication rate, and patient satisfaction were assessed and compared at a mean follow-up of 16 months.
Results
Injecting tranexamic acid into the knee joint cavity can effectively reduce the hidden blood loss and total blood loss (
P
<0.001), and reduce the patient’s early postoperative inflammation biomarkers, pain status, and limb swelling. Therefore, the patient can obtain a better range of motion following total knee arthroplasty. In the long run, in terms of joint function and surgical satisfaction, there are no statistically significant differences. In addition, there are no statistically significant differences between the two groups of patients in terms of the total amount of FVIII usage, length of stay, and hospitalization expenses.
Conclusion
In patients with haemophilia, intra-articular injection of tranexamic acid during total knee arthroplasty can effectively reduce postoperative blood loss, early postoperative inflammation levels, pain and limb swelling, and enable patients to receive higher-quality rehabilitation exercises to get better joint function. Previous studies on TKA in haemophilic patients have already demonstrated the efficacy of intra-articular injections of TXA in reducing postoperative blood loss. Our study confirms this efficacy.</description><identifier>ISSN: 0341-2695</identifier><identifier>EISSN: 1432-5195</identifier><identifier>DOI: 10.1007/s00264-023-05983-8</identifier><identifier>PMID: 37740768</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Medicine ; Medicine & Public Health ; Original Paper ; Orthopedics</subject><ispartof>International orthopaedics, 2024-03, Vol.48 (3), p.683-692</ispartof><rights>The Author(s) under exclusive licence to SICOT aisbl 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s) under exclusive licence to SICOT aisbl.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-df723dfccb9f5f5d43269e2655e6319cce6284dd6f7bb5efef9aea81134f7f8a3</citedby><cites>FETCH-LOGICAL-c347t-df723dfccb9f5f5d43269e2655e6319cce6284dd6f7bb5efef9aea81134f7f8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00264-023-05983-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00264-023-05983-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37740768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiang, Si-cheng</creatorcontrib><creatorcontrib>Shen, Shao-ning</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><creatorcontrib>Wang, Zheng-ming</creatorcontrib><creatorcontrib>Jin, Zhao-kai</creatorcontrib><creatorcontrib>Su, Hai</creatorcontrib><creatorcontrib>Tong, Pei-jian</creatorcontrib><creatorcontrib>Lv, Shuai-jie</creatorcontrib><title>Intra-articular injection of tranexamic acid in patients with haemophilia arthritis: retrospective controlled study in total knee arthroplasty</title><title>International orthopaedics</title><addtitle>International Orthopaedics (SICOT)</addtitle><addtitle>Int Orthop</addtitle><description>Purpose
Total knee arthroplasty is the main method for the treatment of advanced haemophilic knee arthritis. Due to the particularity of hemophilia, the blood management plan is the focus of the perioperative period for haemophilia patients. This study aimed to investigate the clinical effect and safety of intra-articular injection of tranexamic acid in patients with haemophilia.
Methods
This is a retrospective study. According to whether tranexamic acid is used or not, patients are divided into tranexamic acid group (
n
=30) and non-tranexamic acid group (
n
=29). Total blood loss, intraoperative blood loss, complete blood count, total amount of coagulation factor VIII (FVIII) usage, coagulation biomarkers, inflammatory biomarkers, knee range of motion, knee joint function, pain status, complication rate, and patient satisfaction were assessed and compared at a mean follow-up of 16 months.
Results
Injecting tranexamic acid into the knee joint cavity can effectively reduce the hidden blood loss and total blood loss (
P
<0.001), and reduce the patient’s early postoperative inflammation biomarkers, pain status, and limb swelling. Therefore, the patient can obtain a better range of motion following total knee arthroplasty. In the long run, in terms of joint function and surgical satisfaction, there are no statistically significant differences. In addition, there are no statistically significant differences between the two groups of patients in terms of the total amount of FVIII usage, length of stay, and hospitalization expenses.
Conclusion
In patients with haemophilia, intra-articular injection of tranexamic acid during total knee arthroplasty can effectively reduce postoperative blood loss, early postoperative inflammation levels, pain and limb swelling, and enable patients to receive higher-quality rehabilitation exercises to get better joint function. Previous studies on TKA in haemophilic patients have already demonstrated the efficacy of intra-articular injections of TXA in reducing postoperative blood loss. Our study confirms this efficacy.</description><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Paper</subject><subject>Orthopedics</subject><issn>0341-2695</issn><issn>1432-5195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kc2OFCEUhYnROD2jL-DCsHTDyE9RRbkzk1EnmcSNrgkNF5uWKkqg1H4Jn1naGl264ib3nI-cexB6weg1o3R4XSjlfUcoF4TKUQmiHqEd6wQnko3yMdpR0THC-1FeoMtSjpSyoVfsKboQw9DRNu_Qr7u5ZkNMrsGu0WQc5iPYGtKMk8dtNcNPMwWLjQ2uLfFiaoC5Fvwj1AM-GJjScggxGNwYhxxqKG9whppTWc6g74Btan-kGMHhUld3OmNqqibirzPA5ktLNKWenqEn3sQCzx_eK_T53e2nmw_k_uP7u5u398SKbqjE-YEL563dj1566VrmfgTeSwm9YKO10HPVOdf7Yb-X4MGPBoxiTHR-8MqIK_Rq4y45fVuhVD2FYiHGljetRXPVDsU7qViT8k1qW6SSweslh8nkk2ZUn3vQWw-69aD_9KBVM7184K_7Cdw_y9_DN4HYBKWt5i-Q9TGteW6Z_4f9DQmImMQ</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Xiang, Si-cheng</creator><creator>Shen, Shao-ning</creator><creator>Wang, Rui</creator><creator>Wang, Zheng-ming</creator><creator>Jin, Zhao-kai</creator><creator>Su, Hai</creator><creator>Tong, Pei-jian</creator><creator>Lv, Shuai-jie</creator><general>Springer Berlin Heidelberg</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240301</creationdate><title>Intra-articular injection of tranexamic acid in patients with haemophilia arthritis: retrospective controlled study in total knee arthroplasty</title><author>Xiang, Si-cheng ; Shen, Shao-ning ; Wang, Rui ; Wang, Zheng-ming ; Jin, Zhao-kai ; Su, Hai ; Tong, Pei-jian ; Lv, Shuai-jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-df723dfccb9f5f5d43269e2655e6319cce6284dd6f7bb5efef9aea81134f7f8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Paper</topic><topic>Orthopedics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiang, Si-cheng</creatorcontrib><creatorcontrib>Shen, Shao-ning</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><creatorcontrib>Wang, Zheng-ming</creatorcontrib><creatorcontrib>Jin, Zhao-kai</creatorcontrib><creatorcontrib>Su, Hai</creatorcontrib><creatorcontrib>Tong, Pei-jian</creatorcontrib><creatorcontrib>Lv, Shuai-jie</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International orthopaedics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiang, Si-cheng</au><au>Shen, Shao-ning</au><au>Wang, Rui</au><au>Wang, Zheng-ming</au><au>Jin, Zhao-kai</au><au>Su, Hai</au><au>Tong, Pei-jian</au><au>Lv, Shuai-jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intra-articular injection of tranexamic acid in patients with haemophilia arthritis: retrospective controlled study in total knee arthroplasty</atitle><jtitle>International orthopaedics</jtitle><stitle>International Orthopaedics (SICOT)</stitle><addtitle>Int Orthop</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>48</volume><issue>3</issue><spage>683</spage><epage>692</epage><pages>683-692</pages><issn>0341-2695</issn><eissn>1432-5195</eissn><abstract>Purpose
Total knee arthroplasty is the main method for the treatment of advanced haemophilic knee arthritis. Due to the particularity of hemophilia, the blood management plan is the focus of the perioperative period for haemophilia patients. This study aimed to investigate the clinical effect and safety of intra-articular injection of tranexamic acid in patients with haemophilia.
Methods
This is a retrospective study. According to whether tranexamic acid is used or not, patients are divided into tranexamic acid group (
n
=30) and non-tranexamic acid group (
n
=29). Total blood loss, intraoperative blood loss, complete blood count, total amount of coagulation factor VIII (FVIII) usage, coagulation biomarkers, inflammatory biomarkers, knee range of motion, knee joint function, pain status, complication rate, and patient satisfaction were assessed and compared at a mean follow-up of 16 months.
Results
Injecting tranexamic acid into the knee joint cavity can effectively reduce the hidden blood loss and total blood loss (
P
<0.001), and reduce the patient’s early postoperative inflammation biomarkers, pain status, and limb swelling. Therefore, the patient can obtain a better range of motion following total knee arthroplasty. In the long run, in terms of joint function and surgical satisfaction, there are no statistically significant differences. In addition, there are no statistically significant differences between the two groups of patients in terms of the total amount of FVIII usage, length of stay, and hospitalization expenses.
Conclusion
In patients with haemophilia, intra-articular injection of tranexamic acid during total knee arthroplasty can effectively reduce postoperative blood loss, early postoperative inflammation levels, pain and limb swelling, and enable patients to receive higher-quality rehabilitation exercises to get better joint function. Previous studies on TKA in haemophilic patients have already demonstrated the efficacy of intra-articular injections of TXA in reducing postoperative blood loss. Our study confirms this efficacy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37740768</pmid><doi>10.1007/s00264-023-05983-8</doi><tpages>10</tpages></addata></record> |
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| title | Intra-articular injection of tranexamic acid in patients with haemophilia arthritis: retrospective controlled study in total knee arthroplasty |
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