A20 ameliorates advanced glycation end products-induced melanogenesis by inhibiting NLRP3 inﬂammasome activation in human dermal fibroblasts

Advanced glycation end products (AGEs) promote melanogenesis through activating NLRP3 inﬂammasome in fibroblasts. Although A20 has been highlighted to inhibit NLRP3 inﬂammasome activation, its roles and mechanisms remain elusive in photoaging-associated pigmentation. To determine the significance of...

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Veröffentlicht in:	Journal of dermatological science 2023-11, Vol.112 (2), p.71-82
Hauptverfasser:	Wang, Mengyao, Huang, Xianyin, Ouyang, Mengting, Lan, Jingjing, Huang, Jingqian, Li, Hongpeng, Lai, Wei, Gao, Yifeng, Xu, Qingfang
Format:	Artikel
Sprache:	eng
Schlagworte:	A20 Advanced glycation end products Animals Dermal fibroblast Fibroblasts - metabolism Glycation End Products, Advanced - metabolism Humans Inflammasomes - metabolism Melanins - metabolism Melanocyte Melanogenesis Mice Monophenol Monooxygenase - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inflammasome Signal Transduction
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