Silk protein sericin: a promising therapy for Achilles tendinopathy—evidence from an experimental rat model

Objective This study investigated the efficacy of sericin in treating experimental Achilles tendinopathy (AT) in rats via the transforming growth factor-beta (TGF-β)/mothers against decapentaplegic (Smad) pathway compared with diclofenac sodium (DS). Method An AT model was induced in rats using coll...

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Veröffentlicht in:	Clinical rheumatology 2023-12, Vol.42 (12), p.3361-3373
Hauptverfasser:	Sayin, Dilek, Gundogdu, Gulsah, Kilic-Erkek, Ozgen, Gundogdu, Koksal, Coban, Hatice Siyzen, Abban-Mete, Gulcin
Format:	Artikel
Sprache:	eng
Schlagworte:	Achilles Tendon Animal models Animals Antioxidants Antioxidants - therapeutic use Collagen (type I) Collagenase Connective tissue growth factor Connective tissues Decorin Degeneration Diclofenac Enzyme-linked immunosorbent assay Fibers Growth factors Medicine Medicine & Public Health Original Article Oxidants Oxidative stress Rats Rheumatology Sericins - pharmacology Sericins - therapeutic use Smad protein Smad2 protein Tendinopathy - drug therapy Transforming Growth Factor beta - metabolism Transforming Growth Factor beta1 Transforming growth factor-b Transforming growth factor-b1
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