Association of clozapine and norclozapine levels with patient and therapy characteristics—focus on interaction with valproic acid

Purpose The goal of the study was to examine clozapine (CLZ) and norclozapine (NCLZ) therapeutic drug monitoring (TDM) data and associated sources of pharmacokinetic variability, particularly the impact of valproic acid (VPA) use. Methods This study included 126 patients with psychiatric disorders o...

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Veröffentlicht in:	European journal of clinical pharmacology 2023-11, Vol.79 (11), p.1557-1564
Hauptverfasser:	Panić, Bojana, Jovanović, Marija, Lukić, Vera, Vučićević, Katarina, Miljković, Branislava, Milovanović, Srđan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Biomedical and Life Sciences Biomedicine Clozapine Dosage Drug dosages Forensic medicine Mental disorders Metabolism Metabolites Patients Pharmacokinetics Pharmacology Pharmacology/Toxicology Pharmacy Schizophrenia Serum levels Smoking Statistical analysis Therapeutic drug monitoring Valproic acid
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