Single-Cell RNA Sequencing Reveals That Adaptation of Human Aortic Endothelial Cells to Antiproliferative Therapies Is Modulated by Flow-Induced Shear Stress

Endothelial cells (ECs) are capable of quickly responding in a coordinated manner to a wide array of stresses to maintain vascular homeostasis. Loss of EC cellular adaptation may be a potential marker for cardiovascular disease and a predictor of poor response to endovascular pharmacological interve...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2023-12, Vol.43 (12), p.2265-2281
Hauptverfasser:	Salazar-Martín, Antonio G, Kalluri, Aditya S, Villanueva, Martin A, Hughes, Travis K, Wadsworth, 2nd, Marc H, Dao, Tyler T, Balcells, Mercedes, Nezami, Farhad R, Shalek, Alex K, Edelman, Elazer R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Cells, Cultured Endothelial Cells Humans Mice Paclitaxel - pharmacology Sequence Analysis, RNA Sirolimus - pharmacology Stress, Mechanical
Online-Zugang:	Volltext
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