Compartmental tongue surgery for intermediate‐advanced squamous cell carcinoma: A multicentric study
BackgroundA multicentric study was conducted on technical reproducibility of compartmental tongue surgery (CTS) in advanced tongue cancers (OTSCC) and comparison to standard wide margin surgery (SWMS).MethodsWe studied 551 patients with OTSCC treated by CTS and 50 by SWMS. Oncological outcomes were...
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| Veröffentlicht in: | Head & neck 2023-11, Vol.45 (11), p.2862-2873 |
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| creator | Calabrese, Luca Tagliabue, Marta Grammatica, Alberto De Berardinis, Rita Corso, Federica Gazzini, Luca Abousiam, Monir Fazio, Enrico Mattavelli, Davide Fontanella, Walter Giannini, Lorenzo Bresciani, Lorenzo Bruschini, Roberto Gandini, Sara Piazza, Cesare Ansarin, Mohssen |
| description | BackgroundA multicentric study was conducted on technical reproducibility of compartmental tongue surgery (CTS) in advanced tongue cancers (OTSCC) and comparison to standard wide margin surgery (SWMS).MethodsWe studied 551 patients with OTSCC treated by CTS and 50 by SWMS. Oncological outcomes were analyzed. A propensity score was performed to compare survival endpoints for the two cohorts.ResultsIn the CTS group, survival and prognosis were significantly associated with positive lymph‐nodes, extranodal extension, depth of invasion and involvement of the soft tissue connecting the tongue primary tumor to neck lymph nodes (T‐N tract), independently from the center performing the surgery. SWMS versus CTS showed a HR Cause‐Specific Survival (CSS) of 3.24 (95% CI: 1.71–6.11; p |
| doi_str_mv | 10.1002/hed.27517 |
| format | Article |
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Oncological outcomes were analyzed. A propensity score was performed to compare survival endpoints for the two cohorts.ResultsIn the CTS group, survival and prognosis were significantly associated with positive lymph‐nodes, extranodal extension, depth of invasion and involvement of the soft tissue connecting the tongue primary tumor to neck lymph nodes (T‐N tract), independently from the center performing the surgery. SWMS versus CTS showed a HR Cause‐Specific Survival (CSS) of 3.24 (95% CI: 1.71–6.11; p < 0.001); HR Loco‐Regional Recurrence Free Survival (LRRFS) of 2.54 (95% CI: 1.47–4.40; p < 0.001); HR Overall Survival (OS) of 0.11 (95% CI: 0.01–0.77; p = 0.03).ConclusionPerforming the CTS could provide better CSS and LRRFS than SWMS regardless of the center performing the surgery, in advanced OTSSC.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.27517</identifier><language>eng</language><publisher>Houston: Wiley Subscription Services, Inc</publisher><subject>Lymph nodes ; Medical prognosis ; Oral cancer ; Squamous cell carcinoma ; Surgery ; Tongue</subject><ispartof>Head & neck, 2023-11, Vol.45 (11), p.2862-2873</ispartof><rights>2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c325t-a2cf01508aa36e231d6571f5fac7fd0d2c0b6a8cb779b4b3677f28b99ad6523f3</citedby><cites>FETCH-LOGICAL-c325t-a2cf01508aa36e231d6571f5fac7fd0d2c0b6a8cb779b4b3677f28b99ad6523f3</cites><orcidid>0000-0001-7023-6746 ; 0000-0002-7879-4846 ; 0000-0003-4959-587X ; 0000-0002-8384-5388 ; 0000-0002-2391-9357</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids></links><search><creatorcontrib>Calabrese, Luca</creatorcontrib><creatorcontrib>Tagliabue, Marta</creatorcontrib><creatorcontrib>Grammatica, Alberto</creatorcontrib><creatorcontrib>De Berardinis, Rita</creatorcontrib><creatorcontrib>Corso, Federica</creatorcontrib><creatorcontrib>Gazzini, Luca</creatorcontrib><creatorcontrib>Abousiam, Monir</creatorcontrib><creatorcontrib>Fazio, Enrico</creatorcontrib><creatorcontrib>Mattavelli, Davide</creatorcontrib><creatorcontrib>Fontanella, Walter</creatorcontrib><creatorcontrib>Giannini, Lorenzo</creatorcontrib><creatorcontrib>Bresciani, Lorenzo</creatorcontrib><creatorcontrib>Bruschini, Roberto</creatorcontrib><creatorcontrib>Gandini, Sara</creatorcontrib><creatorcontrib>Piazza, Cesare</creatorcontrib><creatorcontrib>Ansarin, Mohssen</creatorcontrib><title>Compartmental tongue surgery for intermediate‐advanced squamous cell carcinoma: A multicentric study</title><title>Head & neck</title><description>BackgroundA multicentric study was conducted on technical reproducibility of compartmental tongue surgery (CTS) in advanced tongue cancers (OTSCC) and comparison to standard wide margin surgery (SWMS).MethodsWe studied 551 patients with OTSCC treated by CTS and 50 by SWMS. Oncological outcomes were analyzed. A propensity score was performed to compare survival endpoints for the two cohorts.ResultsIn the CTS group, survival and prognosis were significantly associated with positive lymph‐nodes, extranodal extension, depth of invasion and involvement of the soft tissue connecting the tongue primary tumor to neck lymph nodes (T‐N tract), independently from the center performing the surgery. SWMS versus CTS showed a HR Cause‐Specific Survival (CSS) of 3.24 (95% CI: 1.71–6.11; p < 0.001); HR Loco‐Regional Recurrence Free Survival (LRRFS) of 2.54 (95% CI: 1.47–4.40; p < 0.001); HR Overall Survival (OS) of 0.11 (95% CI: 0.01–0.77; p = 0.03).ConclusionPerforming the CTS could provide better CSS and LRRFS than SWMS regardless of the center performing the surgery, in advanced OTSSC.</description><subject>Lymph nodes</subject><subject>Medical prognosis</subject><subject>Oral cancer</subject><subject>Squamous cell carcinoma</subject><subject>Surgery</subject><subject>Tongue</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpd0MtKw0AUBuAgCtbqwjcYcKOL1LkkM4m7UrxBwY2uw8lcakomaecidOcj-Iw-iVPrytU5i4-fnz_LLgmeEYzp7btWMypKIo6yCcG1yDErxPH-L1jOsChOszPv1xhjxgs6ycxitBtwweohQI_COKyiRj66lXY7ZEaHuiFoZ7XqIOjvzy9QHzBIrZDfRrBj9EjqvkcSnOyG0cIdmiMb-9DJlOg6iXyIaneenRjovb74u9Ps7eH-dfGUL18enxfzZS4ZLUMOVBpMSlwBMK4pI4qXgpjSgBRGYUUlbjlUshWibouWcSEMrdq6hgQpM2yaXR9yN27cRu1DYzu_LwiDTl0bWnEuOKkLlujVP7oeoxtSu6RElSSpeVI3ByXd6L3Tptm4zoLbNQQ3-8WbtHjzuzj7AW4_djQ</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Calabrese, Luca</creator><creator>Tagliabue, Marta</creator><creator>Grammatica, Alberto</creator><creator>De Berardinis, Rita</creator><creator>Corso, Federica</creator><creator>Gazzini, Luca</creator><creator>Abousiam, Monir</creator><creator>Fazio, Enrico</creator><creator>Mattavelli, Davide</creator><creator>Fontanella, Walter</creator><creator>Giannini, Lorenzo</creator><creator>Bresciani, Lorenzo</creator><creator>Bruschini, Roberto</creator><creator>Gandini, Sara</creator><creator>Piazza, Cesare</creator><creator>Ansarin, Mohssen</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7023-6746</orcidid><orcidid>https://orcid.org/0000-0002-7879-4846</orcidid><orcidid>https://orcid.org/0000-0003-4959-587X</orcidid><orcidid>https://orcid.org/0000-0002-8384-5388</orcidid><orcidid>https://orcid.org/0000-0002-2391-9357</orcidid></search><sort><creationdate>20231101</creationdate><title>Compartmental tongue surgery for intermediate‐advanced squamous cell carcinoma: A multicentric study</title><author>Calabrese, Luca ; Tagliabue, Marta ; Grammatica, Alberto ; De Berardinis, Rita ; Corso, Federica ; Gazzini, Luca ; Abousiam, Monir ; Fazio, Enrico ; Mattavelli, Davide ; Fontanella, Walter ; Giannini, Lorenzo ; Bresciani, Lorenzo ; Bruschini, Roberto ; Gandini, Sara ; Piazza, Cesare ; Ansarin, Mohssen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-a2cf01508aa36e231d6571f5fac7fd0d2c0b6a8cb779b4b3677f28b99ad6523f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Lymph nodes</topic><topic>Medical prognosis</topic><topic>Oral cancer</topic><topic>Squamous cell carcinoma</topic><topic>Surgery</topic><topic>Tongue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calabrese, Luca</creatorcontrib><creatorcontrib>Tagliabue, Marta</creatorcontrib><creatorcontrib>Grammatica, Alberto</creatorcontrib><creatorcontrib>De Berardinis, Rita</creatorcontrib><creatorcontrib>Corso, Federica</creatorcontrib><creatorcontrib>Gazzini, Luca</creatorcontrib><creatorcontrib>Abousiam, Monir</creatorcontrib><creatorcontrib>Fazio, Enrico</creatorcontrib><creatorcontrib>Mattavelli, Davide</creatorcontrib><creatorcontrib>Fontanella, Walter</creatorcontrib><creatorcontrib>Giannini, Lorenzo</creatorcontrib><creatorcontrib>Bresciani, Lorenzo</creatorcontrib><creatorcontrib>Bruschini, Roberto</creatorcontrib><creatorcontrib>Gandini, Sara</creatorcontrib><creatorcontrib>Piazza, Cesare</creatorcontrib><creatorcontrib>Ansarin, Mohssen</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calabrese, Luca</au><au>Tagliabue, Marta</au><au>Grammatica, Alberto</au><au>De Berardinis, Rita</au><au>Corso, Federica</au><au>Gazzini, Luca</au><au>Abousiam, Monir</au><au>Fazio, Enrico</au><au>Mattavelli, Davide</au><au>Fontanella, Walter</au><au>Giannini, Lorenzo</au><au>Bresciani, Lorenzo</au><au>Bruschini, Roberto</au><au>Gandini, Sara</au><au>Piazza, Cesare</au><au>Ansarin, Mohssen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Compartmental tongue surgery for intermediate‐advanced squamous cell carcinoma: A multicentric study</atitle><jtitle>Head & neck</jtitle><date>2023-11-01</date><risdate>2023</risdate><volume>45</volume><issue>11</issue><spage>2862</spage><epage>2873</epage><pages>2862-2873</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>BackgroundA multicentric study was conducted on technical reproducibility of compartmental tongue surgery (CTS) in advanced tongue cancers (OTSCC) and comparison to standard wide margin surgery (SWMS).MethodsWe studied 551 patients with OTSCC treated by CTS and 50 by SWMS. Oncological outcomes were analyzed. A propensity score was performed to compare survival endpoints for the two cohorts.ResultsIn the CTS group, survival and prognosis were significantly associated with positive lymph‐nodes, extranodal extension, depth of invasion and involvement of the soft tissue connecting the tongue primary tumor to neck lymph nodes (T‐N tract), independently from the center performing the surgery. SWMS versus CTS showed a HR Cause‐Specific Survival (CSS) of 3.24 (95% CI: 1.71–6.11; p < 0.001); HR Loco‐Regional Recurrence Free Survival (LRRFS) of 2.54 (95% CI: 1.47–4.40; p < 0.001); HR Overall Survival (OS) of 0.11 (95% CI: 0.01–0.77; p = 0.03).ConclusionPerforming the CTS could provide better CSS and LRRFS than SWMS regardless of the center performing the surgery, in advanced OTSSC.</abstract><cop>Houston</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/hed.27517</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-7023-6746</orcidid><orcidid>https://orcid.org/0000-0002-7879-4846</orcidid><orcidid>https://orcid.org/0000-0003-4959-587X</orcidid><orcidid>https://orcid.org/0000-0002-8384-5388</orcidid><orcidid>https://orcid.org/0000-0002-2391-9357</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Lymph nodes Medical prognosis Oral cancer Squamous cell carcinoma Surgery Tongue |
| title | Compartmental tongue surgery for intermediate‐advanced squamous cell carcinoma: A multicentric study |
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