Combination of downregulating FEN1 and PD-1 blockade enhances antitumor activity of CD8+ T cells against HNSCC cells in vitro

Programmed cell death ligand 1 (PD-L1) and human leukocyte antigen/major histocompatibility complex (HLA/MHC) are two main kinds of immunophenotypes affecting the susceptibility to anti-PD therapy. Our previous study found that down-regulation of flap endonuclease-1 (FEN1) could not only inhibit PD-...

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Veröffentlicht in:	Journal of oral pathology & medicine 2023-10, Vol.52 (9), p.834-842
Hauptverfasser:	Wang, Xiangjian, Xu, Shenjie, Fu, Tao, Wu, Yang, Sun, Weilian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor activity Apoptosis Apoptosis - drug effects B7-H1 Antigen - metabolism CD8 antigen CD8-Positive T-Lymphocytes Cell culture Cell cycle Cell death Cell Line, Tumor Coculture Techniques Down-Regulation Endonuclease Enzyme-linked immunosorbent assay FEN1 protein Flap Endonucleases Flow cytometry Granzyme B Head & neck cancer Head and neck carcinoma Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - immunology Head and Neck Neoplasms - metabolism Histocompatibility antigen HLA Humans Immune Checkpoint Inhibitors - pharmacology Lymphocytes Lymphocytes T Major histocompatibility complex Metastases PD-L1 protein Programmed Cell Death 1 Receptor - antagonists & inhibitors Secretions Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - immunology Tumor necrosis factor
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