Plasma Protein Binding Determination for Unstable Ester Prodrugs: Remdesivir and Tenofovir Alafenamide

•The addition of an organophosphate esterase inhibitor, dichlorvos, stabilized remdesivir (RDV) during equilibrium dialysis for plasma protein binding (PPB) determination.•Dichlorvos did not impact the unbound fraction (fu) of RDV in plasma, and an equilibrium dialysis method for RDV was developed w...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2023-12, Vol.112 (12), p.3224-3232
Hauptverfasser:	Wen, Anita, Qin, Ann Ran-Ran, Tarnowski, Thomas, Ling, Kah Hiing John, Zhang, Haeyoung, Humeniuk, Rita, Regan, Sean, Saquing, Jovita, Liu, Wenbin, Venkatarangan, Lata, Xiao, Deqing
Format:	Artikel
Sprache:	eng
Schlagworte:	dichlorvos equilibrium dialysis esterase inhibitor fit for purpose plasma prodrug Protein binding remdesivir (RDV) tenofovir alafenamide (TAF) ultrafiltration
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