The in vitro metabolism of GMDTC in liver microsomes of human, monkey, dog, rat and mouse: Metabolic stability assessment, metabolite identification and interspecies comparison

Sodium (S)− 2-(dithiocarboxylato((2 S,3 R,4 R,5 R)− 2,3,4,5,6-pentahydroxyhexyl)amino)− 4(methylthio)butanoate (GMDTC) is a compound that removes cadmium from kidney cells. This study aims to investigate the metabolic stability and metabolite identification of GMDTC in various liver microsomes, incl...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2023-11, Vol.236, p.115718-115718, Article 115718
Hauptverfasser:	Hu, Wei, Zhong, Zhi-Yong, Ren, Xue-Feng, Liu, Hai-Yang, Tang, Xiao-Jiang
Format:	Artikel
Sprache:	eng
Schlagworte:	GMDTC Interspecies differences Liver microsomes Metabolic stability Metabolite identification
Online-Zugang:	Volltext
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