Evaluating Tumor Hypoxia Radiosensitization Via Electron Paramagnetic Resonance Oxygen Imaging (EPROI)

Purpose Tumor hypoxia contributes to aggressive phenotypes and diminished therapeutic responses to radiation therapy (RT) with hypoxic tissue being 3-fold less radiosensitive than normoxic tissue. A major challenge in implementing hypoxic radiosensitizers is the lack of a high-resolution imaging mod...

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Veröffentlicht in:	Molecular imaging and biology 2024-06, Vol.26 (3), p.435-447
Hauptverfasser:	Rickard, Ashlyn G., Mowery, Yvonne M., Bassil, Alex, Rouse, Douglas C., Williams, Nerissa T., Charity, Theresa, Belloni, Rafaela, Crouch, Brian, Ramanujam, Nimmi, Stevenson, Daniel, Castillo, Rico, Blocker, Stephanie, Epel, Boris, Kotecha, Mrignayani, Palmer, Gregory M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Breast cancer Cell Line, Tumor Diffuse reflectance spectroscopy Electron paramagnetic resonance Electron spin resonance Electron Spin Resonance Spectroscopy Female Hemoglobin High resolution Hypoxia Image resolution Imaging Malignancy Medical imaging Medicine Medicine & Public Health Mice Mice, Inbred C57BL Oxygen Oxygen - metabolism Oxygenation Phenotypes Radiation therapy Radiation Tolerance - drug effects Radiation-Sensitizing Agents - pharmacology Radiation-Sensitizing Agents - therapeutic use Radiology Radiosensitization Radiosensitizers Regression models Research Article Resonance Sarcoma Sarcoma - diagnostic imaging Sarcoma - drug therapy Sarcoma - metabolism Sarcoma - pathology Sarcoma - radiotherapy Soft tissues Spectroscopy Survivability Syngeneic grafts Tumor Hypoxia Tumor microenvironment Tumors Variance analysis
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