Levels of angiopoietin-2 are predictive for mortality in yellow fever virus infected patients
In 2018 there was a large yellow fever outbreak in São Paulo, Brazil, with a high fatality rate. Yellow fever virus can cause, among other symptoms, haemorrhage and disseminated intravascular coagulation, indicating a role for endothelial cells in the disease pathogenesis. Here, we conducted a case-...
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| Veröffentlicht in: | The Journal of infectious diseases 2023-09 |
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| creator | van de Weg, Cornelia A M Thomazella, Mateus V Marmorato, Mariana P Correia, Carolina A Dias, Juliana Z C Maestri, Alvino Zanella, Luiz G F A B E Cerqueira, Natalia B Félix, Alvina C Moreira, Carlos H V Buccheri, Renata Costa, Priscilla R Kallás, Esper G |
| description | In 2018 there was a large yellow fever outbreak in São Paulo, Brazil, with a high fatality rate. Yellow fever virus can cause, among other symptoms, haemorrhage and disseminated intravascular coagulation, indicating a role for endothelial cells in the disease pathogenesis. Here, we conducted a case-control study and measured markers related to endothelial damage in plasma and its association with mortality. We found that angiopoietin-2 is strongly associated with a fatal outcome and could serve as a predictive marker for mortality. This could be used to monitor severe patients and provide care to improve disease outcome. |
| doi_str_mv | 10.1093/infdis/jiad389 |
| format | Article |
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| source | Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| title | Levels of angiopoietin-2 are predictive for mortality in yellow fever virus infected patients |
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